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公开(公告)号：EP3963060A1
公开(公告)日：2022-03-09
申请号：EP20726971.3
申请日：2020-04-30
发明人： SAGI, Irit , AFRATIS, Nikolaos A.
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公开(公告)号：EP1402562B1
公开(公告)日：2009-02-11
申请号：EP02738591.3
申请日：2002-06-17
发明人： ZAJFMAN, Daniel , HEBER, Oded , PEDERSEN, Henrik, B. , RUDICH, Yinon , SAGI, Irit , RAPPAPORT, Michael
IPC分类号： H01J49/40
CPC分类号： H01J3/40 , H01J49/027 , H01J49/406 , H01J49/4245
摘要： A method for trapping of a plurality of charged particles in a charged particle trap. The trap includes first and second electrode mirrors (2, 3) having a common optical axis (4), the mirrors being arranged in alignment at two extremities thereof. The mirrors are capable, when voltage is applied thereto, of creating respective electric fields defined by key field parameters. The electric fields are configured to reflect charged particles causing their oscillation between the mirrors. The method includes introducing into the trap, along the optical axis, the plurality of charged particles as a beam (10) having pre-determined key beam parameters. The method further includes choosing the key field parameters for at least one of the mirrors such as to induce bunching among charged particles in the beam.
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公开(公告)号：EP3256135A1
公开(公告)日：2017-12-20
申请号：EP16748836.0
申请日：2016-02-09
发明人： SAGI, Irit , TALMI-FRANK, Dalit , SOLOMONOV, Inna , AMIT, Ido
IPC分类号： A61K31/65 , A61K38/39 , A61K39/395 , A61P31/16
CPC分类号： A61K39/3955 , A61K31/196 , A61K31/215 , A61K31/351 , A61K45/06 , A61K2039/505 , C07K16/40 , A61K2300/00
摘要： A method of treating or preventing a disease associated with a secondary infection in a subject infected with a pathogen is provided. The method comprises administering to the subject a therapeutically effective amount of an anti-pathogenic agent directed towards the pathogen and a therapeutically effective amount of an agent which down-regulates at least one extracellular matrix-associated polypeptide.
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公开(公告)号：EP3216805A1
公开(公告)日：2017-09-13
申请号：EP16198239.2
申请日：2011-01-27
IPC分类号： C07K16/44
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/44 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to an antibody which inhibits the catalytic activity of MMP-9 and MMP-2 comprising an antigen recognition region which comprises the six CDR amino acid sequences as set forth in SEQ ID NOs: 4, 5, 6, 7, 8 and 9.
摘要翻译： 本发明涉及抑制包含抗原识别区的MMP-9和MMP-2的催化活性的抗体，所述抗原识别区包含如SEQ ID NO：4,5,6,7,8所示的六个CDR氨基酸序列 和9。
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5.发明公开
公开(公告)号：EP1610678A2
公开(公告)日：2006-01-04
申请号：EP04725641.7
申请日：2004-04-04
发明人： SAGI, Irit , DANON, Tamar
CPC分类号： C07K16/40 , A61K39/395 , A61K2039/505 , C07K16/44
摘要： A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor.
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6.发明公开
公开(公告)号：EP2846819A1
公开(公告)日：2015-03-18
申请号：EP13729107.6
申请日：2013-05-09
发明人： SAGI, Irit , WONG, Eitan , AFIK, Ran
CPC分类号： A61K38/4886 , C12N9/6489 , C12Y304/24086 , Y02A50/473
摘要： A method of treating an inflammatory disease is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polypeptide comprising a pro-domain of TNF-alpha converting enzyme (TACE), said polypeptide being devoid of a catalytic domain of said TACE, said polypeptide comprising a modification at a site selected from the group consisting of R58, R56 and K57 which renders said polypeptide resistant to furin degradation said polypeptide being capable of downregulating an activity of TACE, thereby treating the inflammatory disease.
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公开(公告)号：EP2528949A1
公开(公告)日：2012-12-05
申请号：EP11705282.9
申请日：2011-01-27
IPC分类号： C07K16/44
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/44 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要： The present application relates to antibodies which recognize [2 (2 -aminoethylcarbomoyl) - ethoxymethyl] -tris- [2-N- (3 - imidazol - 1 -yl -propyl) ) -etho xymethyl] methane, a hapten molecule which closely mimics the local structure and conformation of the reactive zinc site in matrix metalloproteinases. An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs : 4-15. Uses thereof are also disclosed.
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公开(公告)号：EP3920965A1
公开(公告)日：2021-12-15
申请号：EP20708205.8
申请日：2020-02-10
发明人： SAGI, Irit , MOHAN, Vishnu
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公开(公告)号：EP1610678B1
公开(公告)日：2011-07-27
申请号：EP04725641.7
申请日：2004-04-04
发明人： SAGI, Irit , DANON, Tamar
CPC分类号： C07K16/40 , A61K39/395 , A61K2039/505 , C07K16/44
摘要： A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor.
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公开(公告)号：EP4380973A2
公开(公告)日：2024-06-12
申请号：EP22757372.2
申请日：2022-08-02
发明人： SAGI, Irit , MAZOR, Roei David , SHULMAN, Ziv
IPC分类号： C07K16/28 , C07K16/40 , A61K39/395 , A61P35/00
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