公开(公告)号：EP0638799A1

公开(公告)日：1995-02-15

申请号：EP94112362.2

申请日：1994-08-08

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： Yedgar, Saul ,  Gavish, Benjamin ,  Chen, Shugi

IPC分类号： G01N21/05

CPC分类号： G01N21/05 ,  G01N15/1404 ,  G01N2021/0346 ,  Y10T436/25 ,  Y10T436/2575

摘要： A flow-cell device for the monitoring of blood or any other cell suspension under flow comprising: a rigid transparent base having a pair of holes with inlets and outlets, one hole for transferring the cell suspension from a supplying means to a flow channel and the other hole for transferring the tested suspension back from the flow channel to a receiving means, a flow-channel plate sandwiched between the base and a transparent plate wherein the flow channel is a wide opening in the middle of the flow-channel plate, said flow-channel plate can be an integral part of either the base or the transparent plate, a transparent plate covering the flow-channel plate, a rigid cover covering the transparent plate with a hole enabling a microscope objective to approach the flow-channel plate, the transparent plate and the cover being attached to each other firmly by any conventional means or the transparent plate being an integral part of the cover.

摘要翻译： 一种用于监测血液或流下任何其它细胞悬浮液的流通池装置，包括：具有一对具有入口和出口的孔的刚性透明基底，用于将细胞悬浮液从供给装置转移到流动通道的一个孔， 用于将测试悬浮液从流动通道传送到接收装置的另一个孔，夹在基部和透明板之间的流动通道板，其中流动通道在流动通道板的中间是宽敞的开口，所述流动 通道板可以是基底或透明板的一体部分，覆盖流动通道板的透明板，覆盖透明板的刚性盖，其具有使显微镜物镜接近流动通道板的孔， 透明板，并且盖通过任何常规方式牢固地彼此附接，或者透明板是盖的整体部分。

公开(公告)号：EP0315349B1

公开(公告)日：1993-02-03

申请号：EP88309996.2

申请日：1988-10-24

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： Yedgar, Saul ,  Dagan, Arie

IPC分类号： A61K47/00 ,  A61K47/30

CPC分类号： A61K47/62 ,  A61K47/61

公开(公告)号：EP2845596A2

公开(公告)日：2015-03-11

申请号：EP14180931.9

申请日：2001-01-10

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： Shoseyov, David ,  Golomb, Gershon ,  Reich, Reuven ,  Ginsburg, Isaac ,  Higazi, Abd-al-Roof ,  Ligumski, Moshe ,  Krimsky, Miron ,  Ojcius, David ,  Van der Woude, Fokko Johannes ,  Schnitzer, Edit ,  Yard, Benito Antonio ,  Yedgar, Saul

IPC分类号： A61K31/70 ,  A61K31/715 ,  A61K31/727 ,  A61K31/695 ,  C07H5/04 ,  C07H5/06 ,  C07H21/00 ,  C07H13/04 ,  C08B37/08 ,  C08B37/10 ,  A61K47/48

CPC分类号： A61K47/544

摘要： A phospholipid conjugate according to the general formula (I)

or according to the general formula (II)

for use in the treatment or prevention of a disorder selected from skin hypersensitivity, respiratory disease, eye disorder, and inflammatory bowel disease.

摘要翻译： 根据通式（I）或根据通式（II）的磷脂结合物，其用于治疗或预防选自皮肤超敏反应性，呼吸系统疾病，眼睛疾病和炎症性肠病的病症。

公开(公告)号：EP2845596A3

公开(公告)日：2015-07-15

申请号：EP14180931.9

申请日：2001-01-10

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： Shoseyov, David ,  Golomb, Gershon ,  Reich, Reuven ,  Ginsburg, Isaac ,  Higazi, Abd-al-Roof ,  Ligumski, Moshe ,  Krimsky, Miron ,  Ojcius, David ,  Van der Woude, Fokko Johannes ,  Schnitzer, Edit ,  Yard, Benito Antonio ,  Yedgar, Saul

IPC分类号： A61K31/70 ,  A61K31/715 ,  A61K31/727 ,  A61K31/695 ,  C07H5/04 ,  C07H5/06 ,  C07H21/00 ,  C07H13/04 ,  C08B37/08 ,  C08B37/10 ,  A61K47/48

CPC分类号： A61K47/544

摘要： A phospholipid conjugate according to the general formula (I)

or according to the general formula (II)

for use in the treatment or prevention of a disorder selected from skin hypersensitivity, respiratory disease, eye disorder, and inflammatory bowel disease.

公开(公告)号：EP0315349A1

公开(公告)日：1989-05-10

申请号：EP88309996.2

申请日：1988-10-24

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： Yedgar, Saul ,  Dagan, Arie

IPC分类号： A61K47/00 ,  A61K47/30

CPC分类号： A61K47/62 ,  A61K47/61

摘要： Inhibitors of phospholipase A 2 activity at the cell-surface membrane whose molecular structure comprises a cell-permeable PLA z -inhibitor moiety covalently bonded directly or indirectly to a physiologically acceptable carrier moiety which is effective to inhibit cell internalisation of the cell-permeable PLA 2 -inhibitor moiety, with the proviso that phosphatidylserine is not bonded indirectly via divalent dodecanedioyl to dextrane hydrazide.

摘要翻译： 在细胞表面膜上的磷脂酶A2活性的抑制剂，其分子结构包括与生理上可接受的载体部分直接或间接共价键合的细胞可渗透PLA2抑制剂部分，其有效抑制细胞可渗透PLA2抑制剂部分的细胞内化 ，但条件是磷脂酰丝氨酸不通过二价十二烷二酰基直接键合到右旋酰肼。