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公开(公告)号：EP4253519A1
公开(公告)日：2023-10-04
申请号：EP21914947.3
申请日：2021-08-27
发明人： ITO, Saburo
摘要： A cell transferring device includes a head shiftable in three-dimensional directions and a controller that controls a shifting of the head. The head is to be attached with a tip including a leading end portion having a leading end opening for allowing a cell to enter and leave the tip, and includes a mechanism for sucking and discharging the cell into and from the tip through the opening. The controller executes a peeling-off control of causing the tip to peel off the cell adhered to a bottom surface of a well of a culture plate through the head. The controller controls, in the peeling-off control, the head in such a manner that the leading end portion of the tip performs a shifting containing a horizontal component at different positions along a vertical direction, the different positions including a position where the leading end portion comes into contact with the cell adhered to the bottom surface.
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公开(公告)号：EP3604496A1
公开(公告)日：2020-02-05
申请号：EP18788636.1
申请日：2018-02-26
发明人： SAKAMOTO, Masaru , ITO, Saburo , KUMAGAI, Takahiko
摘要： The cell handling device includes a container having a section capable of storing cells; a cell detection unit for detecting a cell stored in the section; a head device for conducting picking of cells, and transfer and release of the picked cells; a control unit for controlling the operation of the head device; and a determination unit for making a determination of a cell state including at least one of the number, properties, and arrangement of the cells stored in the section based on a detection result of the cell detection unit. The control unit causes the head device to execute, according to a state determination result obtained by the determination unit, one operation selected from among operation of picking all the cells stored in the section, operation of picking a part of the cells stored in the section, operation of picking a new cell and releasing the cell in the section, and operation of terminating processing of the section.
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公开(公告)号：EP3330366A1
公开(公告)日：2018-06-06
申请号：EP16830095.2
申请日：2016-03-17
发明人： ITO, Saburo
CPC分类号： G01N35/10 , C12M33/04 , G01N1/14 , G01N35/1009 , G01N35/1074 , G01N2001/1427
摘要： There are prepared a first container (11) which stores a liquid (L1) containing a cellular aggregate (C), a second container (12) which receives a cellular aggregate, and a third container (13) which stores a preliminary treatment solution (L3), and a cylinder tip (1). The cylinder tip (1) is formed with a syringe (2) including a tubular passage (2P) having a front end opening (24) which sucks the cellular aggregate (C), and a plunger (3) which reciprocates in a tubular passage. Before sucking the cellular aggregate from the first container (11) and discharging the same to the third container (13), the preliminary treatment solution (L3) is retained in a space between the tubular passage (2P) and the plunger (3) by dipping the front end opening (24) of the cylinder tip (1) into the preliminary treatment solution (L3) in the third container (13) and causing the plunger (3) to reciprocate.
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公开(公告)号：EP3081627A1
公开(公告)日：2016-10-19
申请号：EP13898961.1
申请日：2013-12-12
发明人： ITO, Saburo
IPC分类号： C12M1/00
摘要： Provided is a well plate that carries, in a carrying position, a subject retained in liquid, the well plate including an upper surface, a lower surface, and a plurality of recessed sections formed in the carrying position. Each of the plurality of recessed sections is opened on the upper surface side, has a shape recessed from the upper surface side to the lower surface side, and includes, in a cross section in an up-down direction, a bottom section in which a first surface having a zero curvature or a first curvature is formed and the subject is carried, and a side section in which a second surface having a second curvature larger than the first curvature and continuous to the first surface is formed.
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6.发明公开SUCTION TIP, OBJECT OBSERVATION DEVICE USING SAID SUCTION TIP, AND METHOD FOR OBSERVING OBJECT 审中-公开吸嘴，使用所述吸嘴的对象观察装置，以及观察对象的方法
公开(公告)号：EP2933625A1
公开(公告)日：2015-10-21
申请号：EP12889856.6
申请日：2012-12-13
发明人： ITO, Saburo
CPC分类号： G01N1/14 , B01L3/0275 , B01L3/0286 , B01L2200/0615 , B01L2200/0668 , B01L2300/0832 , B01L2300/0883 , C12M33/04 , C12M47/04 , G01N35/1011 , G01N2001/002 , G01N2001/1025 , G01N2035/00564 , G01N2035/103 , G01N2035/1062
摘要： Disclosed are a suction tip, an object observation device and an object observing method using the suction tip. The suction tip is provided with an internal tubular passage serving as a suction path for sucking an object, a distal end portion disposed in a substantially vertical direction when in use and including a suction port for sucking the object, the suction port being an opening formed in one end of the tubular passage; and a trap portion formed downstream of the distal end portion in a suction direction, and configured to trap the object to be sucked through the suction port. According to the suction tip, the object observation device and the object observing method using the suction tip, it is easy to collect the object, without falling and discharging of the collected object in the gravitational direction.
摘要翻译： 公开了一种抽吸尖端，一种物体观测装置以及一种使用该抽吸尖端的物体观测方法。 在吸引端部设置有作为用于吸引被吸附物的吸引路径的内部管状通路，在使用时配置在大致铅直方向上的前端部，具有用于吸引被吸附物的吸引口，吸引口是形成的开口 在管状通道的一端; 以及形成于所述前端部的吸引方向下游侧的捕捉部，通过所述吸引口捕捉所述吸引对象物。 根据抽吸尖端，物体观测装置和使用抽吸尖端的物体观测方法，容易收集物体，而不会使收集到的物体在重力方向上掉落和排出。
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公开(公告)号：EP2796538A1
公开(公告)日：2014-10-29
申请号：EP11878294.5
申请日：2011-12-20
发明人： ITO, Saburo
CPC分类号： B65G43/08 , B01L3/502761 , B01L2300/0681 , B01L2300/0829 , B01L2400/0439 , C12M47/04 , G01N21/6452 , G01N21/6458 , G01N2021/6439 , G01N2500/00 , G02B21/0024 , G02B21/0092 , G02B21/125 , G02B21/16
摘要： An object selecting device includes a container including an inner bottom part and configured to store liquid, a plate having a top surface and a bottom surface, including a through hole at a support position for the selection object and to be immersed in the liquid, a determining means for determining whether or not the supported object is good, and a removing means for removing the object determined to be defective. Out of a collection of objects having different shapes, only the selection object having a predetermined shape can be supported by the plate. Whether or not any non-object having a distorted shape is included in the objects supported by the plate is determined by the determining means. If such a non-object is present, it can be removed by the removing means. Since the supported selection object needs not be extracted such as by suction while causing forced deformation or the like, it can be gently extracted by a method such as vertical inversion of the plate. Thus, only the selection object having the predetermined shape can be selected without being deformed or destroyed.
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公开(公告)号：EP3730598A1
公开(公告)日：2020-10-28
申请号：EP18902209.8
申请日：2018-12-11
发明人： KUMAGAI, Takahiko , ITO, Saburo , AKITA, Kumi
摘要： A cell transfer device (S) includes a base (1) on which a container (2) accommodating a plurality of cells (C) is mounted, a head (61) with a suction tip (12) attached that sucks the cells in the container (2), and a control unit (7) that controls the head (61). The cells (C) are placed on a placement surface (31A) that is an upper surface of an underlying culture medium layer (31) including a gel-like culture medium. The control unit (7) acquires information on a height position of the placement surface (31A), specifies a suction height for the cells existing at a first point on the placement surface (31A), and causes the suction tip (12) to suck the cells. Then, the control unit (7) causes the suction tip (12) to suck the cells existing at a second point different from the first point on the placement surface (31A) by using the suction height of the first point.
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公开(公告)号：EP3517602A1
公开(公告)日：2019-07-31
申请号：EP16919403.2
申请日：2016-10-17
发明人： ITO, Saburo
摘要： A cell transfer apparatus transfers cells from a dish in which the cells are held to a microplate where a plurality of wells are classified into a plurality of groups. The cell transfer apparatus includes a camera unit (5) that captures an image of the dish with the cells being held in the dish, an evaluation unit (74) that gives evaluation levels to the plurality of cells held in the dish, respectively, based on the image of the dish with reference to predetermined multiple-step evaluation level for the cells, an allocation processor (75) that sets transfer destinations of the cells on the dish so that the cells equal in evaluation level are distributed evenly to the groups in the microplate, and a shaft controller (76) that transfers the cells in accordance with the transfer destinations set by the allocation processor (75).
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