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公开(公告)号：EP3273971A1
公开(公告)日：2018-01-31
申请号：EP16771532.5
申请日：2016-03-27
发明人： HORNSTEIN, Eran , REICHENSTEIN, Irit , CHEN, Alon
IPC分类号： A61K31/7088 , C12N15/113
CPC分类号： A61K31/7105 , A61K45/06 , A61P25/00 , C12N15/113 , C12N2310/14 , C12N2310/141
摘要： A method of treating a subject having MND is provided. The method comprising administering to the subject a therapeutically effective amount of an agent selected from the group consisting of miR-218, miR-218*, precursor thereof and a polynucleotide sequence encoding miR-218 or miR-218* or precursor thereof, thereby treating the MND in the subject. A method of treating a subject having MND, the method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating an activity or expression of a gene product selected from the group consisting of KCND2, KCNH1, GABRB2, SLC6A1, SLC6A11, KCNA1, CACNB4, GRIA2, GRIK2, GABRG1 and GRIK3, is also provided.
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2.发明公开SYSTEMS AND METHODS OF MONITORING SOCIAL INTERACTIONS IN A GROUP OF ORGANISMS OVER A PERIOD OF AT LEAST 24 HOURS IN A SEMI-NATURAL ENVIRONMENT 审中-公开系统和监测社会相互作用在至少24小时的一段机构组成的集团在半自然环境方法
公开(公告)号：EP2739134A1
公开(公告)日：2014-06-11
申请号：EP12819653.2
申请日：2012-08-03
CPC分类号： G06F17/5009 , A01K1/031 , A01K29/005 , G01S3/14 , G01S3/7864 , G06K9/6282
摘要： A method of identifying and classifying social complex behaviors among a group of model organisms, comprising implanting at least one RFID transponder in each model organism in said group of model organisms; enclosing said group of model organisms in a monitored space divided into RFID monitored segments; RFID tracking a position of each model organism by reading said at least one RFID transponder in each model organism over a period of time; capturing a sequence of images of each model organism over said period of time; and calculating at least one spatiotemporal model of each model organism based on time synchronization of said RFID tracked position of said model organism with said sequence of images.
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公开(公告)号：EP2373301B1
公开(公告)日：2013-11-06
申请号：EP09806203.7
申请日：2009-12-03
发明人： HORNSTEIN, Eran , CHEN, Alon , HARAMATI, Sharon , CHAPNIK, Elik
CPC分类号： C12N15/113 , A61K31/7088
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公开(公告)号：EP4277635A1
公开(公告)日：2023-11-22
申请号：EP22739278.4
申请日：2022-01-18
IPC分类号： A61K31/713 , A61K31/7088 , A61K31/7105 , C12N15/113 , A61P25/24 , A61P35/00
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公开(公告)号：EP2373301A2
公开(公告)日：2011-10-12
申请号：EP09806203.7
申请日：2009-12-03
发明人： HORNSTEIN, Eran , CHEN, Alon , HARAMATI, Sharon , CHAPNIK, Elik
CPC分类号： C12N15/113 , A61K31/7088
摘要： Use of an agent which upregulates an activity or amount of miRNA-9 or miRNA-9* is disclosed for the preparation of a medicament for the treatment of a motor neuron disease (MND).
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6.发明公开
公开(公告)号：EP4319731A1
公开(公告)日：2024-02-14
申请号：EP22723812.8
申请日：2022-04-08
申请人： Yeda Research and Development Co. Ltd , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： CHEN, Alon , LOPEZ, Juan Pablo
IPC分类号： A61K31/135 , A61K31/27 , A61P25/24
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公开(公告)号：EP4218771A1
公开(公告)日：2023-08-02
申请号：EP22199393.4
申请日：2016-03-27
发明人： HORNSTEIN, Eran , REICHENSTEIN, Irit , CHEN, Alon
IPC分类号： A61K31/7105 , A61K45/06 , C12N15/113 , A61P25/00
摘要： The present invention refers to an agent selected from the group consisting of miR-218, miR-218*, precursor thereof and a polynucleotide sequence encoding miR-218 or miR-218* or precursor thereof, for use in the treatment of a motor neuron disease (MND).
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8.发明授权MIR-135 AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT OF SEROTONIN ASSOCIATED MEDICAL CONDITIONS 有权MIR-135和组合物用于治疗血清素介导的医学莱顿
公开(公告)号：EP2739736B1
公开(公告)日：2017-04-19
申请号：EP12759827.4
申请日：2012-08-02
发明人： CHEN, Alon , HORNSTEIN, Eran , ISSLER, Orna , HARAMATI, Sharon , VOLK, Naama
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： A61K31/7105 , A61K31/713 , A61K48/0058 , C12N15/113 , C12N2310/141 , C12Q1/6883 , C12Q2600/178
摘要： microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.
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9.发明公开MICRO-RNAS AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT AND DIAGNOSIS OF SEROTONIN-, ADRENALIN-, NORADRENALIN-, GLUTAMATE-, AND CORTICOTROPIN-RELEASING HORMONE- ASSOCIATED MEDICAL CONDITIONS 审中-公开微小RNA和组合物用于治疗和血清素，肾上腺素，去甲肾上腺素，谷氨酸诊断和促肾上腺皮质激素释放激素介导的医学莱顿
公开(公告)号：EP3102679A2
公开(公告)日：2016-12-14
申请号：EP15710264.1
申请日：2015-02-05
发明人： CHEN, Alon , ISSLER, Orna
IPC分类号： C12N15/11 , A61K31/7088
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/141 , C12N2320/30 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.
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10.发明公开
公开(公告)号：EP2739736A2
公开(公告)日：2014-06-11
申请号：EP12759827.4
申请日：2012-08-02
发明人： CHEN, Alon , HORNSTEIN, Eran , ISSLER, Orna , HARAMATI, Sharon , VOLK, Naama
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： A61K31/7105 , A61K31/713 , A61K48/0058 , C12N15/113 , C12N2310/141 , C12Q1/6883 , C12Q2600/178
摘要： microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.
摘要翻译： 提供microRNA和组合物，包含相同的用于治疗和血清素，adrenaline-，去甲肾上腺素，谷氨酸，和诊断肾上腺皮质激素释放激素相关的医学病症。
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