公开(公告)号：EP2739612B1

公开(公告)日：2017-06-21

申请号：EP12756262.7

申请日：2012-08-01

申请人： Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. ,  Bar-Ilan University ,  Diab R&D 1

发明人： SASSON, Shlomo ,  CERASI, Erol ,  GRUZMAN, Arie Lev ,  MELTZER-MATS, Ella

IPC分类号： C07D277/74 ,  C07D277/78 ,  C07D417/12 ,  C07D235/28 ,  A61K31/428 ,  A61K31/4184 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D471/04 ,  C07D233/88 ,  C07D235/28 ,  C07D239/38 ,  C07D249/12 ,  C07D277/54 ,  C07D277/74 ,  C07D277/78 ,  C07D277/82 ,  C07D285/135 ,  C07D311/58 ,  C07D339/02 ,  C07D339/08 ,  C07D417/12

公开(公告)号：EP2739612A1

公开(公告)日：2014-06-11

申请号：EP12756262.7

申请日：2012-08-01

申请人： Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. ,  Bar-Ilan University ,  Diab R&D 1

发明人： SASSON, Shlomo ,  CERASI, Erol ,  GRUZMAN, Arie Lev ,  MELTZER-MATS, Ella

IPC分类号： C07D277/74 ,  C07D277/78 ,  C07D417/12 ,  C07D235/28 ,  A61K31/428 ,  A61K31/4184 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D471/04 ,  C07D233/88 ,  C07D235/28 ,  C07D239/38 ,  C07D249/12 ,  C07D277/54 ,  C07D277/74 ,  C07D277/78 ,  C07D277/82 ,  C07D285/135 ,  C07D311/58 ,  C07D339/02 ,  C07D339/08 ,  C07D417/12

摘要： The present invention is directed to compounds such as: formula wherein linker is independently selected from the group consisting of -S-, -S-S-, -S-(CH2)n-, -NH-, -NH-(CH2)n-, -0-, -S02-, arylene, heteroarylene; Rl is selected from the group consisting of straight or branched C4- C20 alkyl, straight or branched C4-C20 alkenyl, straight or branched C4-C20 alkynyl, each optionally interrupted with at least one NH, C5- C7 saturated cycloalkyl or heteroalkyl ring, C5-C12 aromatic or het- eroaromatic ring, each optionally substituted with at least one group selected from -COOH, -NH2, C1-C8 alkoxy, C1-C5 amidyle, C1-C5 car- boxyl, halogen; and R2 is independently selected from the group consisting of H, OH, SH, NH2, N02, halogen, CN, C1-C8 alkoxy, C1-C5 carboxylic acid, straight or branched C1-C8 alkyl, straight or branched C2-C10 alkenyl, straight or branched C2 - C12 alkynyl each optionally substituted by at least one substituent selected from the group consisting of C1-C5 alkoxy, C1-C5 carboxylic acid, OH, SH, NH2, halogen; and compositions for use in the treatment of diabetes and related dis¬ orders.

公开(公告)号：EP1554299B1

公开(公告)日：2013-01-30

申请号：EP03758618.7

申请日：2003-10-20

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED

发明人： SASSON, Shlomo ,  CERASI, Erol ,  GRUZMAN, Arie ,  KATZHENDLER, Joshua

IPC分类号： C07H15/00 ,  A61K31/70 ,  C07D493/04 ,  C07D495/04

CPC分类号： C07H9/04 ,  C07H15/04 ,  C07H15/14