公开(公告)号：EP1814986A2

公开(公告)日：2007-08-08

申请号：EP05809259.4

申请日：2005-11-24

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI) ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)

发明人： GERTLER, Arieh ,  CALLEBAUT, Isabelle ,  DJIANE, Jean

IPC分类号： C12N15/10

CPC分类号： C07K14/5759 ,  A61K47/60

摘要： The invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39-42 of a leptin polypeptide sequence are substituted with different amino acid residues such that the site becomes less hydrophobic, and fragments of said leptin antagonists.

公开(公告)号：EP1814986B1

公开(公告)日：2011-02-16

申请号：EP05809259.4

申请日：2005-11-24

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM ,  UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS VI) ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)

发明人： GERTLER, Arieh ,  CALLEBAUT, Isabelle ,  DJIANE, Jean

IPC分类号： C12N15/10

CPC分类号： C07K14/5759 ,  A61K47/60