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    PYRIDINE DERIVATIVES
    1.
    发明公开
    PYRIDINE DERIVATIVES 失效
    吡啶衍生物。

    公开(公告)号：EP0066628A1

    公开(公告)日：1982-12-15

    申请号：EP82900034.8

    申请日：1981-12-09

    申请人： Yoshitomi Pharmaceutical Industries, Ltd.

    发明人： OE, Takanori ,  TSURUDA, Mineo ,  GOTO, Kazuhiro ,  HISADOME, Masao

    IPC分类号： C07D213/63 ,  C07D213/70 ,  C07D401/14 ,  A61K31/44

    CPC分类号： C07D213/64 ,  C07D213/61 ,  C07D213/70 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Pyridine derivatives represented by the following general formula
    wherein R 1 , R 2 , R3, and R 4 , which may the same or different, each represents a hydrogen atom or a lower alkyl group, or R 1 and R 2 , or R 3 and R 4 , are taken together to form a hetero ring together with the adjacent nitrogen atom, A 1 and A 2 , which may be the same or different, each represents an alkylene or hydroxy-substituted alkylene group, Y' and Y 2 , which may be the same or different, each represents an oxygen or sulfur atom, and Z represents
    or the pharmaceutically acceptable acid addition salts thereof. These compounds show pharmacological effects such as acceleration of leukocyte phagocytosis, acceleration of macrophage phagocytosis, acceleration of production of rosette forming cells of spleen, and depression of adjuvant arthritis, thus being useful as medicines.

    IMIDAZOLE DERIVATIVES
    4.
    发明公开
    IMIDAZOLE DERIVATIVES 失效
    咪唑衍生物

    公开(公告)号：EP0110996A1

    公开(公告)日：1984-06-20

    申请号：EP83900734.1

    申请日：1983-02-28

    申请人： Yoshitomi Pharmaceutical Industries, Ltd.

    发明人： TSURUDA, Mineo ,  OE, Takanori ,  KAWASAKI, Kazuyuki ,  MIKASHIMA, Hiroshi ,  YASUDA, Hiroshi

    IPC分类号： C07D233/60 ,  C07D233/61 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D405/04 ,  C07D405/10 ,  C07D405/14 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Imidazole derivatives represented by the general formula (1), wherein R 1 and R 4 each represents a hydrogen atom or a lower alkyl group, R 2 and R 3 each represents a hydrogen atom, a halogen atom, a hydroxy group, a lower alkyl group, a lower alkoxy group, an aralkyloxy group, a nitro group or an amino group, A represents -0-, -S-, -CH=CH- or -CH=N-, Z represents an aryl group, a thienyl group, a pyridyl group or a furyl group, with the aromatic (or heterocyclic) rings being optionally substituted by 1 to 3 same or different substituents selected from among halogen, lower alkyl, cyclic alkyl, lower alkoxy, hydroxy, carboxy, lower alkoxycarbonyl, carboxy lower alkoxy, di(lower alkyl)-amino lower alkoxy, and nitro, pharmaceutically acceptable acid addition salts thereof, a process for their preparation, and a medicinal composition containing them. These compounds have an effect of inhibiting biosynthesis of thromboxane A 2 , an effect of suppressing aggregation of thrombocytes, a vasodilative effect, and an effect of protecting liver disorder.

    摘要翻译： 由通式（1）表示的咪唑衍生物，其中R 1和R 4各自表示氢原子或低级烷基，R 2和R 3各自表示氢原子，卤素原子，羟基，低级烷基，低级 烷氧基，芳烷氧基，硝基或氨基，A表示-O - ， - S - ， - CH = CH-或-CH = N-，Z表示芳基，噻吩基，吡啶基 芳基（或杂环）环任选被1至3个相同或不同的选自卤素，低级烷基，环状烷基，低级烷氧基，羟基，羧基，低级烷氧基羰基，羧基低级烷氧基，二 （低级烷基） - 氨基低级烷氧基和硝基，其药学上可接受的酸加成盐，其制备方法以及含有它们的药物组合物。 这些化合物具有抑制凝血恶烷A2的生物合成，抑制血小板凝集的效果，血管舒张作用，保护肝脏障碍的效果。