公开(公告)号：EP4397655A1

公开(公告)日：2024-07-10

申请号：EP22876896.6

申请日：2022-09-29

申请人： Yuhan Corporation

发明人： KIM, Eun-Kyung ,  LIM, Cheol-Hee ,  LEE, Kang-Yo ,  CHOI, Hyun-Ho

IPC分类号： C07D235/04 ,  A61K31/4184 ,  A61P11/00 ,  A61P43/00 ,  A61P1/16

CPC分类号： A61K31/4184 ,  A61P1/16 ,  A61P11/00 ,  A61P13/12 ,  A61P43/00 ,  C07D235/04

摘要： The present invention provides a bicyclic fused ring (for example, benzo[d]imidazole, benzo[d][1,2,3]triazole, or 8-oxo-8,9-dihydro-7H-purine) derivative or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof. The bicyclic fused ring derivative or pharmaceutically acceptable salt thereof has an inhibitory activity against the lysyl oxidase family and can be usefully applied for preventing or treating various diseases associated with the lysyl oxidase family, such as idiopathic pulmonary fibrosis (IPF), non-alcoholic steatohepatitis (NASH), chronic kidney disease (CKD), or liver cirrhosis.