公开(公告)号：EP1315488B1

公开(公告)日：2006-10-25

申请号：EP01930024.3

申请日：2001-05-10

申请人： ZERIA PHARMACEUTICAL CO., LTD.

发明人： UEKI, Shigeru, c/o Zeria Pharmaceutical Co., Ltd. ,  HORI, Yuko, c/o Zeria Pharmaceutical Co., Ltd. ,  MATSUNAGA, Yugo, c/o Zeria Pharmeutical Co., Ltd. ,  NAGASAWA, Masaaki, Zeria Pharmaceutical Co., Ltd. ,  NISHIOKA, Hiroyasu, Zeria Pharmaceutical Co., Ltd. ,  MURATA, Masakazu, c/o Zeria Pharmaceutical Co.,Ltd

IPC分类号： A61K31/426 ,  A61P1/00

CPC分类号： A61K31/426 ,  A61K31/381

摘要： Remedies effective for the improvement of colonic motor dysfunction such as irritable bowel syndrome, constipation or intestinal atony without causing side effects on the central nerve system. These colonic motor dysfunction remedies comprise, as active ingredients, aminothiazole derivatives represented by the following formula (I) or a salt or hydrate thereof: wherein R , R and R may be the same or different and each independently represent a hydrogen atom or a hydroxyl, lower alkyl, lower alkoxy, amino, nitro or cyano group, R and R may be the same or different and each independently represent a hydrogen atom or a lower alkyl group, and n stands for an integer of from 2 to 4.