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1.发明公开SUBSTITUTED ACETAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND ANTIULCER DRUG CONTAINING SAME 失效取代的乙酰胺衍生物，方法为生产和抗肿瘤药物，这包括。
公开(公告)号：EP0404949A1
公开(公告)日：1991-01-02
申请号：EP89907820.8
申请日：1989-07-04
发明人： SHINOZAKI, Katsuo c/o Zeria Pharm. Co.Ltd. Centr. , ISHII, Katsuyuki c/o Zeria Pharm. Co.Ltd. Centr. , UEDA, Ikuo
IPC分类号： C07D207/12 , C07D233/64 , C07D295/08 , C07D317/22 , A61K31/40 , A61K31/445
CPC分类号： C08B37/0015 , A61K47/6951 , B82Y5/00 , C07D207/12 , C07D233/64 , C07D295/096 , C07D317/22
摘要： This invention relates to substituted acetamide derivatives represented by general formula (I), salts thereof, cyclodextrin inclusion compounds thereof, and an antiulcer drug containing same as an active ingredient, wherein Y represents a piperidino group, a 1-pyrrolidinyl group or a 3-hydroxy-1-pyrrolidinyl group, and Z represents a group selected from among groups (a) to (e): (a) cyano group, (b), (c), (d) and (e). The compounds (I) possess an excellent antiulcer activity and a high safty, and hence an antiulcer drug containing same is useful as a drug for prophylaxis and treatment of acute or chronic gastric ulcer, duodenal ulcer, gastritis and hyperacidity.
摘要翻译： 本发明涉及substituiertem由通式（I）表示的乙酰胺衍生物，它们的盐，环糊精包合化合物，以及它们的在抗溃疡药含有相同的活性成分，worin Y代表哌啶子基，1-吡咯基或3- 羟基-1-吡咯烷基，Z表示从基（A）中选择的基团（E）：（A）氰基，（b），（C），（d）和（e）中。 化合物（I）具有优异的抗溃疡活性和安全性高，以及因此抗溃疡药含有相同的是作为急性或慢性胃溃疡，十二指肠溃疡，胃炎和胃酸过多的预防和治疗药物是有用的。
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2.发明授权INDOLEACETIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING SAME AS ACTIVE INGREDIENTS 失效吲哚衍生物，方法为生产和药物，以此作为活性剂包括在内。
公开(公告)号：EP0382854B1
公开(公告)日：1994-12-14
申请号：EP89907824.0
申请日：1989-07-04
IPC分类号： C07D209/28 , C07D403/12 , A61K31/405
CPC分类号： C07D403/12 , C07D209/28
摘要： The invention relates to indoleacetic acid derivatives represented by general formula (I), [wherein X represents a piperidino group, a 1-pyrrolidinyl group or a 3-hydroxy-1-pyrrolidinyl group, Y represents α, (wherein R1 represents a hydrogen atom or a lower alkyl group, and $(1,3)$ represents 0, 1 or 2) or β, (wherein R2 represents a hydrogen atom, a lower akyl group or a hydroxy group, m represents 0, 1 or 2, and n represents 1, 2 or 3)] and their salts, and antiinflammatory agents, antirheumatic agents and antiulcer agents containing them as active ingredients. The compounds possess a strong antiinflammatory action while causing extremely reduced troubles of digestive organs which is a serious defect with conventional non-steroidal antiinflammatory agents, and possess an excellent antiulcer action as well.
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3.发明公开INDOLEACETIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING SAME AS ACTIVE INGREDIENTS 失效吲哚衍生物，方法为生产和药物，以此作为活性剂包括在内。
公开(公告)号：EP0382854A1
公开(公告)日：1990-08-22
申请号：EP89907824.0
申请日：1989-07-04
IPC分类号： C07D209/28 , C07D403/12 , A61K31/405
CPC分类号： C07D403/12 , C07D209/28
摘要： The invention relates to indoleacetic acid derivatives represented by general formula (I), [wherein X represents a piperidino group, a 1-pyrrolidinyl group or a 3-hydroxy-1-pyrrolidinyl group, Y represents a, (wherein R' represents a hydrogen atom or a lower alkyl group, and ℓ represents 0, 1 or 2) or β, (wherein R 2 represents a hydrogen atom, a lower akyl group or a hydroxy group, m represents 0, 1 or 2, and n represents 1, 2 or 3)] and their salts, and antiinflammatory agents, antirheumatic agents and antiulcer agents containing them as active ingredients. The compounds possess a strong antiinflammatory action while causing extremely reduced troubles of digestive organs which is a serious defect with conventional non-steroidal antiinflammatory agents, and possess an excellent antiulcer action as well.
摘要翻译： 吲哚乙酸derivs。 式（I）和它们的盐是新的，其中X是哌啶子基，1-或3-羟基-1-吡咯烷基; Y是 - （CHR 1）K-O-或 - （S（O））间 - （CHR 2）N-O-; R 1是H或低级烷基; R 2是H，低级烷基或OH; k为0，1或2; m是0，1或2; n是1，2或第三
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