-
公开(公告)号：EP3057984B1
公开(公告)日：2018-07-11
申请号：EP14795564.5
申请日：2014-10-17
IPC分类号： C07K14/605 , A61K38/26 , A61K38/28 , A61K45/06 , A61K31/137 , A61K31/155 , A61K31/198 , A61K31/485 , A61K31/7048
CPC分类号： C07K14/605 , A61K31/137 , A61K31/155 , A61K31/198 , A61K31/485 , A61K31/7048 , A61K38/26 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel acylated glucagon analog peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
-
公开(公告)号：EP3057984A1
公开(公告)日：2016-08-24
申请号：EP14795564.5
申请日：2014-10-17
IPC分类号： C07K14/605 , A61K38/26
CPC分类号： C07K14/605 , A61K31/137 , A61K31/155 , A61K31/198 , A61K31/485 , A61K31/7048 , A61K38/26 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel acylated glucagon analog peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供了用于治疗肥胖和过量体重，糖尿病和其他相关代谢紊乱的材料和方法。 特别地，本发明提供了在这些方法中有效的新型酰化胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性来介导其作用。
-
公开(公告)号：EP2895505B1
公开(公告)日：2019-11-06
申请号：EP13765701.1
申请日：2013-09-17
发明人： TOLBORG, Jakob Lind , FOSGERAU, Keld , NØRREGARD, Pia , JUST, Rasmus , RIBER, Ditte , HAMPRECHT, Dieter Wolfgang , AUGUSTIN, Robert , THOMAS, Leo , RIST, Wolfgang
IPC分类号： C07K14/605 , A61K38/26
-
公开(公告)号：EP2895505A1
公开(公告)日：2015-07-22
申请号：EP13765701.1
申请日：2013-09-17
发明人： TOLBORG, Jakob Lind , FOSGERAU, Keld , NØRREGARD, Pia , JUST, Rasmus , RIBER, Ditte , HAMPRECHT, Dieter Wolfgang , AUGUSTIN, Robert , THOMAS, Leo , RIST, Wolfgang
IPC分类号： C07K14/605 , A61K38/26
摘要： The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel glucagon analog peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
摘要翻译： 本发明提供了用于治疗肥胖和过量体重，糖尿病和其他相关代谢紊乱的材料和方法。 特别地，本发明提供了在这些方法中有效的新型胰高血糖素类似物肽。 与人胰高血糖素相比，肽可以通过增加对GLP-1受体的选择性来介导其作用。
-
公开(公告)号：EP2528901B9
公开(公告)日：2017-01-25
申请号：EP11701796.2
申请日：2011-01-24
发明人： OOST, Thorsten , ANDERSKEWITZ, Ralf , HAMPRECHT, Dieter, Wolfgang , HOENKE, Christoph , MARTYRES, Domnic , RIST, Wolfgang , SEITHER, Peter
IPC分类号： C07D401/06 , C07D405/12 , C07D231/12 , A61K31/415 , A61P29/00 , A61P37/00
CPC分类号： C07D231/12 , C07D401/06 , C07D405/12
-
公开(公告)号：EP2688882A1
公开(公告)日：2014-01-29
申请号：EP12709623.8
申请日：2012-03-15
发明人： MARTYRES, Domnic , ANDERSKEWITZ, Ralf , HOENKE, Christoph , KRIEGL, Jan , OOST, Thorsten , RIST, Wolfgang , SEITHER, Peter
IPC分类号： C07D403/10 , A61P29/00 , A61K31/4155
CPC分类号： C07D403/10 , A61K31/335 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/4184 , A61K31/421 , A61K31/437 , A61K31/52 , A61K45/06 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2 antagonistic activity, wherein L, Y1, Y2, Y3, Y4, Y5, Z, R1, R2, R3 and n have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical compositions containing said compounds and to pharmaceutical compositions containing said compounds in combination with one or more active substances.
-
公开(公告)号：EP2566864A2
公开(公告)日：2013-03-13
申请号：EP11718989.4
申请日：2011-05-06
发明人： GRAUERT, Matthias , BAKKER, Remko , BREITFELDER, Steffen , BUETTNER, Frank , EICKELMANN, Peter , FOX, Thomas , GRUNDL, Marc , LEHMANN-LINTZ, Thorsten , RIST, Wolfgang
IPC分类号： C07D413/04 , C07D413/14 , A61K31/501 , A61P3/00
CPC分类号： C07D413/10 , C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D498/04
摘要： The present invention relates to pyridazinone derivatives of general formula (I), wherein the groups A, G and R
1 are as defined in the application, the tautomers thereof, stereoisomers thereof, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.-
公开(公告)号：EP2528901B1
公开(公告)日：2015-05-27
申请号：EP11701796.2
申请日：2011-01-24
发明人： OOST, Thorsten , ANDERSKEWITZ, Ralf , HAMPRECHT, Dieter, Wolfgang , HOENKE, Christoph , MARTYRES, Domnic , RIST, Wolfgang , SEITHER, Peter
IPC分类号： C07D401/06 , C07D405/12 , C07D231/12 , A61K31/415 , A61P29/00 , A61P37/00
CPC分类号： C07D231/12 , C07D401/06 , C07D405/12
-
公开(公告)号：EP2528901A1
公开(公告)日：2012-12-05
申请号：EP11701796.2
申请日：2011-01-24
发明人： OOST, Thorsten , ANDERSKEWITZ, Ralf , HAMPRECHT, Dieter, Wolfgang , HOENKE, Christoph , MARTYRES, Domnic , RIST, Wolfgang , SEITHER, Peter
IPC分类号： C07D231/12 , A61K31/415 , A61P29/00 , A61P37/00
CPC分类号： C07D231/12 , C07D401/06 , C07D405/12
摘要： The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2-activity, wherein W, L
1 , L
2 , X, L
3 , Y, R
1 and R
2 are as defined in the specification and claims, to their use as medicaments and to pharmaceutical formulations, containing said compounds or containing a combination of said compounds with one or more active substances.-
公开(公告)号：EP2688882B1
公开(公告)日：2015-05-13
申请号：EP12709623.8
申请日：2012-03-15
发明人： MARTYRES, Domnic , ANDERSKEWITZ, Ralf , HOENKE, Christoph , KRIEGL, Jan , OOST, Thorsten , RIST, Wolfgang , SEITHER, Peter
IPC分类号： C07D403/10 , A61P29/00 , A61K31/4155
CPC分类号： C07D403/10 , A61K31/335 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/4184 , A61K31/421 , A61K31/437 , A61K31/52 , A61K45/06 , C07D471/04 , C07D473/00 , C07D487/04
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.023 秒)
