公开(公告)号：EP4092019A1

公开(公告)日：2022-11-23

申请号：EP21741490.3

申请日：2021-01-12

申请人： Zhejiang Hisun Pharmaceutical Co., Ltd. ,  Hisun Accuray Therapeutics Co., Ltd.

发明人： HUANG, Xiangui ,  GUO, Yanghui ,  QIU, Zongxing ,  BIE, Pingyan ,  LIAO, Weiwei ,  YAN, Qingyan ,  SHEN, Weichao ,  CAO, Hai ,  XING, Qingna ,  WANG, Xin ,  CAO, Qi ,  MENG, Lichen ,  WU, Nuoyi ,  LI, Wenpeng ,  YE, Cheng ,  HU, Taishan ,  CHEN, Lei

IPC分类号： C07D401/14 ,  C07D471/00 ,  C07D491/107 ,  C07D487/04 ,  C07D405/14 ,  C07D413/14 ,  C07D513/10 ,  C07D519/00 ,  A61K31/497 ,  A61K31/675 ,  A61K31/5377 ,  A61P35/00 ,  A61P9/00

摘要： The present invention relates to heteroaryl derivatives, preparation methods therefor, and applications thereof in medicine. Specifically, the present invention relates to a heteroaryl derivative represented by general formula (AI), a preparation method therefor, and a pharmaceutically acceptable salt, and use thereof as a therapeutic agent, in partucular, as an SHP2 allosteric inhibitor, wherein the definition of substituents in general formula (AI) is the same as that in the description.