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公开(公告)号：EP4092019A1
公开(公告)日：2022-11-23
申请号：EP21741490.3
申请日：2021-01-12
发明人： HUANG, Xiangui , GUO, Yanghui , QIU, Zongxing , BIE, Pingyan , LIAO, Weiwei , YAN, Qingyan , SHEN, Weichao , CAO, Hai , XING, Qingna , WANG, Xin , CAO, Qi , MENG, Lichen , WU, Nuoyi , LI, Wenpeng , YE, Cheng , HU, Taishan , CHEN, Lei
IPC分类号： C07D401/14 , C07D471/00 , C07D491/107 , C07D487/04 , C07D405/14 , C07D413/14 , C07D513/10 , C07D519/00 , A61K31/497 , A61K31/675 , A61K31/5377 , A61P35/00 , A61P9/00
摘要： The present invention relates to heteroaryl derivatives, preparation methods therefor, and applications thereof in medicine. Specifically, the present invention relates to a heteroaryl derivative represented by general formula (AI), a preparation method therefor, and a pharmaceutically acceptable salt, and use thereof as a therapeutic agent, in partucular, as an SHP2 allosteric inhibitor, wherein the definition of substituents in general formula (AI) is the same as that in the description.
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2.发明公开
公开(公告)号：EP4177253A1
公开(公告)日：2023-05-10
申请号：EP21832154.5
申请日：2021-06-25
发明人： GUO, Yanghui , MENG, Lichen , HUANG, Xiangui , LIAO, Weiwei , GONG, Yongxiang , XU, Daiwang , HU, Taishan , CHEN, Lei
IPC分类号： C07D413/14 , A61K31/4725 , A61P25/04
摘要： The present invention relates to a pharmaceutically acceptable salt of ( S )-2-(6-fluorobenzo[d]oxazol-2-yl)-6-methoxy-5-((5-methoxypyridin-2-yl))methoxy)-1,2,3,4-tet rahydroisoquinoline-3-carboxylic acid, a preparation method therefor, a pharmaceutical composition comprising the pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, in particular as an angiotensin II type-2 receptor antagonist.
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公开(公告)号：EP4382527A1
公开(公告)日：2024-06-12
申请号：EP22852286.8
申请日：2022-08-04
发明人： GUO, Yanghui , MENG, Lichen , LIAO, Weiwei , ZHANG, Heng , WU, Chengfei , CHEN, Youxi , YE, Cheng , QIAN, Wenjian , CHEN, Lei , WU, Enguo
IPC分类号： C07D413/06 , C07D413/14 , A61K31/42 , A61K31/4439 , A61K31/506 , A61P31/04
CPC分类号： Y02A50/30 , A61K31/42 , A61K31/4439 , A61K31/506 , A61P31/04 , C07D413/14 , C07D413/06
摘要： Disclosed in the present invention are an aromatic acetylene derivative, a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of the aromatic acetylene derivative or the pharmaceutical composition thereof in medicines. Specifically, disclosed in the present invention are an aromatic acetylene derivative as represented by general formula (A-I), a preparation method therefor and a pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, particularly an LPXC inhibitor, wherein the definition of each substituent in the general formula (A-I) is the same as that in the description.
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