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公开(公告)号：EP4092019A1
公开(公告)日：2022-11-23
申请号：EP21741490.3
申请日：2021-01-12
发明人： HUANG, Xiangui , GUO, Yanghui , QIU, Zongxing , BIE, Pingyan , LIAO, Weiwei , YAN, Qingyan , SHEN, Weichao , CAO, Hai , XING, Qingna , WANG, Xin , CAO, Qi , MENG, Lichen , WU, Nuoyi , LI, Wenpeng , YE, Cheng , HU, Taishan , CHEN, Lei
IPC分类号： C07D401/14 , C07D471/00 , C07D491/107 , C07D487/04 , C07D405/14 , C07D413/14 , C07D513/10 , C07D519/00 , A61K31/497 , A61K31/675 , A61K31/5377 , A61P35/00 , A61P9/00
摘要： The present invention relates to heteroaryl derivatives, preparation methods therefor, and applications thereof in medicine. Specifically, the present invention relates to a heteroaryl derivative represented by general formula (AI), a preparation method therefor, and a pharmaceutically acceptable salt, and use thereof as a therapeutic agent, in partucular, as an SHP2 allosteric inhibitor, wherein the definition of substituents in general formula (AI) is the same as that in the description.
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2.发明公开4-SUBSTITUTED-(3-SUBSTITUTED-1H-PYRAZOLE-5-AMINO)-PYRIMIDINE DERIVATIVES HAVING ACTIVITY OF INHIBITING PROTEIN KINASE AND USE THEREOF 审中-公开4- SUBSTITUT-（3- substitut -1H-吡唑-5-基 - 氨基）对蛋白激酶具有抑制作用-PYRIMIDINDERIVAT及其用途
公开(公告)号：EP2754659A1
公开(公告)日：2014-07-16
申请号：EP11871882.4
申请日：2011-09-05
发明人： DING, Yili , YANG, Xuan , YAN, Qingyan , BAI, Hua , CAI, Lifeng , SMITH, Kenneth , CHAI, Jian
IPC分类号： C07D403/12 , C07D403/14 , C07B43/10 , A61K31/496 , A61P35/00 , A61P31/14 , A61P37/08 , A61P43/00
CPC分类号： C07D403/12 , A61K31/4155 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14
摘要： Provided are derivatives substituted by urea associated with 4-substituted-(3-substituted-1H-pyrazole-5-amino)-pyrimidine-2-amino of formula (I), wherein these compounds may selectively regulate or inhibit an information transmission process controlled by natural or variant tyrosine kinase. Also provided are preparation methods and uses of the compounds.
摘要翻译： 通过与4-取代的 - （3-取代的-1H-吡唑-5-基 - 氨基）嘧啶-2-氨基的式（I）的相关联的尿素取代提供的是衍生物，worin这些化合物可以选择性地调节或抑制到控制信息发送处理 由天然或变体酪氨酸激酶。 所以提供了制备方法和所述化合物的用途。
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3.发明授权METHOD FOR PREPARING FULLY PROTECTION HEPARIN PENTASACCHARIDE AND INTERMEDIATE THEREOF 有权制备全面保护肝素五肽及其中间体的方法
公开(公告)号：EP2857411B1
公开(公告)日：2017-12-06
申请号：EP12877493.2
申请日：2012-05-25
发明人： DING, Yili , GUO, Yanghui , BAI, Hua , WU, Yingqiu , YANG, Xuan , YAN, Qingyan , CHAI, Jian
CPC分类号： C07H15/207 , A61K31/702 , C07H1/00 , C07H5/10 , C07H15/04 , C07H15/18 , C07H15/203
摘要： Disclosed is a process for chemically synthesizing a pharmaceutical intermediate, in particular to a novel intermediate and novel process for synthesizing an anticoagulant drug fondaparinux sodium intermediate - full protection heparin pentasaccharide. The process has a high reaction efficiency and a simple reaction operation, and enables the reaction intermediate to be easily purified, thus being suitable for the industrialized production of the full protection heparin pentasaccharide.
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4.发明公开METHOD FOR PREPARING FULLY PROTECTION HEPARIN PENTASACCHARIDE AND INTERMEDIATE THEREOF 有权用于生产肝素五糖获得完全的保护及其中间体
公开(公告)号：EP2857411A1
公开(公告)日：2015-04-08
申请号：EP12877493.2
申请日：2012-05-25
发明人： DING, Yili , GUO, Yanghui , BAI, Hua , WU, Yingqiu , YANG, Xuan , YAN, Qingyan , CHAI, Jian
IPC分类号： C07H5/04 , C07H5/10 , A61K31/702 , A61P7/02
CPC分类号： C07H15/207 , A61K31/702 , C07H1/00 , C07H5/10 , C07H15/04 , C07H15/18 , C07H15/203
摘要： Disclosed is a process for chemically synthesizing a pharmaceutical intermediate, in particular to a novel intermediate and novel process for synthesizing an anticoagulant drug fondaparinux sodium intermediate - full protection heparin pentasaccharide. The process has a high reaction efficiency and a simple reaction operation, and enables the reaction intermediate to be easily purified, thus being suitable for the industrialized production of the full protection heparin pentasaccharide.
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