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公开(公告)号：EP1668031B1
公开(公告)日：2008-03-12
申请号：EP04809553.3
申请日：2004-08-09
申请人： ZymoGenetics, Inc.
发明人： BRADY, Lowell, J. , KLUCHER, Kevin, M. , CHAN, Chung , DONG, Dennis, L. , LIU, Hong, Y. , SHEPPARD, Paul, O. , BUKOWSKI, Thomas, R.
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： The application provides a fusion protein comprising: (i) a polypeptide that comprises a sequence of amino acids residues selected from the group consisting of SEQ ID NOs: 83, 85, 87, 89, 95, 97, 103, 105, 111, 113, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 159 and 161; and (ii) a polyalkyl oxide moiety.
摘要翻译： 通过突变编码成熟蛋白质的多核苷酸序列中的一个或多个半胱氨酸残基已经产生了IL-28A，IL-28B和IL-29的均质制剂。 可以显示半胱氨酸突变蛋白结合其同源受体或显示生物学活性。 显示的一种生物学活性是抗病毒活性。
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2.发明公开
公开(公告)号：EP1385979A2
公开(公告)日：2004-02-04
申请号：EP02723832.8
申请日：2002-04-12
申请人： ZymoGenetics, Inc.
发明人： POWNDER, Tracey, A. , CHAN, Chung
摘要： The increased use of nucleotide sequence data mining techniques has amplified the demand for efficient methods of producing recombinant proteins in prokaryotic cells. A strategy is provided for enhancing the synthesis of recombinant amino acid sequences by improving translation from expression cassettes in vitro before producing recombinant hosts.
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公开(公告)号：EP1793845A2
公开(公告)日：2007-06-13
申请号：EP05797809.0
申请日：2005-07-29
申请人： ZymoGenetics, Inc.
发明人： DOYLE, Sean , KLUCHER, Kevin, M. , SIVAKUMAR, Pallavur, V. , KINDSVOGEL, Wayne, R. , CHAN, Chung
IPC分类号： A61K38/20
CPC分类号： A61K38/20 , A61K38/21 , A61K47/60 , C07K14/54 , C07K14/715 , C07K14/7155 , A61K2300/00
摘要： Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer and/or autoimmune therapeutics.
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公开(公告)号：EP1668031A2
公开(公告)日：2006-06-14
申请号：EP04809553.3
申请日：2004-08-09
申请人： ZymoGenetics, Inc.
发明人： BRADY, Lowell, J. , KLUCHER, Kevin, M. , CHAN, Chung , DONG, Dennis, L. , LIU, Hong, Y. , SHEPPARD, Paul, O. , BUKOWSKI, Thomas, R.
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： The application provides a fusion protein comprising: (i) a polypeptide that comprises a sequence of amino acids residues selected from the group consisting of SEQ ID NOs: 83, 85, 87, 89, 95, 97, 103, 105, 111, 113, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 159 and 161; and (ii) a polyalkyl oxide moiety.
摘要翻译： 通过突变编码成熟蛋白质的多核苷酸序列中的一个或多个半胱氨酸残基已经产生了IL-28A，IL-28B和IL-29的均质制剂。 可以显示半胱氨酸突变蛋白结合其同源受体或显示生物学活性。 显示的一种生物学活性是抗病毒活性。
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公开(公告)号：EP1551440A2
公开(公告)日：2005-07-13
申请号：EP03786525.0
申请日：2003-10-07
申请人： ZymoGenetics, Inc.
发明人： THOMPSON, Penny, J. , LEWIS, Katherine, E. , JASPERS, Stephen, R. , GARCIA, Richard, M. , WEST, Robert, R. , HOLDERMAN, Susan, D. , CHAN, Chung
CPC分类号： A61K38/1709 , A61K38/00 , C07K14/47 , C07K14/4702 , G01N2800/06
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal funciton with Zven1 and Zven2 polypeptides.
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