公开(公告)号：EP0931148A1

公开(公告)日：1999-07-28

申请号：EP97910128.0

申请日：1997-10-16

申请人： ZymoGenetics, Inc.

发明人： DEISHER, Theresa, A. ,  CONKLIN, Darrell, C. ,  RAYMOND, Fenella, C. ,  BUKOWSKI, Thomas, R. ,  HOLDERMAN, Susan, D. ,  HANSEN, Brigit ,  SHEPPARD, Paul, O.

IPC分类号： C12N15 ,  A61K38 ,  A61P9 ,  A61P19 ,  A61P21 ,  C07K14 ,  C07K16 ,  C07K19 ,  C12N1 ,  C12N5 ,  C12P21

CPC分类号： C12N5/0657 ,  A61K38/00 ,  A61K47/62 ,  A61K47/6835 ,  C07K14/50 ,  C07K16/22 ,  C07K2319/00 ,  C12N2501/119

摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF-5, a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.

公开(公告)号：EP0931148B1

公开(公告)日：2006-03-01

申请号：EP97910128.4

申请日：1997-10-16

申请人： ZymoGenetics, Inc.

发明人： DEISHER, Theresa, A. ,  CONKLIN, Darrell, C. ,  RAYMOND, Fenella, C. ,  BUKOWSKI, Thomas, R. ,  HOLDERMAN, Susan, D. ,  HANSEN, Brigit ,  SHEPPARD, Paul, O.

IPC分类号： C12N15/18 ,  C07K14/50 ,  C07K16/22 ,  C07K19/00 ,  C12N5/10 ,  A61K38/18

CPC分类号： C12N5/0657 ,  A61K38/00 ,  A61K47/62 ,  A61K47/6835 ,  C07K14/50 ,  C07K16/22 ,  C07K2319/00 ,  C12N2501/119

摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF-5, a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.

公开(公告)号：EP1573006B1

公开(公告)日：2009-11-11

申请号：EP03810068.1

申请日：2003-12-12

申请人： ZymoGenetics, Inc.

发明人： CHANG, Chung ,  ZAMOST, Bruce, L. ,  COVERT, Douglas, C. ,  LIU, Hong, Y. ,  DE JONGH, Karen, S. ,  MEYER, Jeffrey, D. ,  HOLDERMAN, Susan, D.

IPC分类号： C12N15/00

CPC分类号： C07K14/54

公开(公告)号：EP1573006A2

公开(公告)日：2005-09-14

申请号：EP03810068.1

申请日：2003-12-12

申请人： ZymoGenetics, Inc.

发明人： CHANG, Chung ,  ZAMOST, Bruce, L. ,  COVERT, Douglas, C. ,  LIU, Hong, Y. ,  DE JONGH, Karen, S. ,  MEYER, Jeffrey, D. ,  HOLDERMAN, Susan, D.

IPC分类号： C12N15/00

CPC分类号： C07K14/54

摘要： The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. . Using the expression vectors, the IL-21 gene was produced in E. coli to a level of greater than 1 g/L in fed batch fermentation. Also included are OmpT deficient E. coli strains transformed with an IL-21 expression vector.

公开(公告)号：EP1551440A2

公开(公告)日：2005-07-13

申请号：EP03786525.0

申请日：2003-10-07

申请人： ZymoGenetics, Inc.

发明人： THOMPSON, Penny, J. ,  LEWIS, Katherine, E. ,  JASPERS, Stephen, R. ,  GARCIA, Richard, M. ,  WEST, Robert, R. ,  HOLDERMAN, Susan, D. ,  CHAN, Chung

IPC分类号： A61K38/00 ,  C07K14/00 ,  C12N5/02 ,  C12N15/74

CPC分类号： A61K38/1709 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4702 ,  G01N2800/06

摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal funciton with Zven1 and Zven2 polypeptides.