公开(公告)号：EP2577314B1

公开(公告)日：2018-01-31

申请号：EP11724588.6

申请日：2011-05-26

申请人： metanomics Health GmbH ,  Universitätsklinikum Schleswig-Holstein ,  Ernst-Moritz-Arndt-Universität Greifswald

发明人： KAMLAGE, Beate ,  RESZKA, Regina ,  KLUTTIG, Martin ,  KALTHOFF, Holger ,  SCHNIEWIND, Bodo ,  MAYERLE, Julia ,  LERCH, Markus

IPC分类号： G01N33/574

CPC分类号： G01N33/574 ,  G01N33/57438

摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreatic cancer in a subject, a method for identifying whether a subject is in need for a therapy of pancreatic cancer or a method for determining whether a pancreatic cancer therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

公开(公告)号：EP2577314A2

公开(公告)日：2013-04-10

申请号：EP11724588.6

申请日：2011-05-26

申请人： metanomics Health GmbH ,  Universitätsklinikum Schleswig-Holstein ,  Ernst-Moritz-Arndt-Universität

发明人： KAMLAGE, Beate ,  RESZKA, Regina ,  KLUTTIG, Martin ,  KALTHOFF, Holger ,  SCHNIEWIND, Bodo ,  MAYERLE, Julia ,  LERCH, Markus

IPC分类号： G01N33/574

CPC分类号： G01N33/574 ,  G01N33/57438

摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreatic cancer in a subject, a method for identifying whether a subject is in need for a therapy of pancreatic cancer or a method for determining whether a pancreatic cancer therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

摘要翻译： 本发明涉及诊断方法领域。 具体地，本发明考虑了用于诊断受试者中胰腺癌的方法，用于鉴定受试者是否需要胰腺癌治疗的方法或者确定胰腺癌治疗是否成功的方法。 本发明还涉及用于执行上述方法的工具，诸如诊断装置。

公开(公告)号：EP3084443A1

公开(公告)日：2016-10-26

申请号：EP14815751.4

申请日：2014-12-19

申请人： metanomics Health GmbH

发明人： KAMLAGE, Beate ,  RESZKA, Regina ,  PETER, Erik ,  KASTLER, Jürgen ,  SCHATZ, Philipp ,  KALTHOFF, Holger ,  SCHNIEWIND, Bodo ,  MAYERLE, Julia ,  LERCH, Markus ,  PILARSKY, Christian ,  GRÜTZMANN, Robert

IPC分类号： G01N33/574

CPC分类号： G01N33/57438 ,  G01N33/49 ,  G01N33/92 ,  G01N2400/00 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08

摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreas cancer in a subject and, preferably for differentiating between pancreatic cancer and pancreatitis and a method for identifying whether a subject is in need for a therapy of pancreatic cancer. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

摘要翻译： 本发明涉及的诊断方法的领域。 具体而言，本发明涉及用于诊断受试者中的胰腺癌和，优选为胰腺癌和胰腺炎和用于标识是否一个受试者需要用于胰腺癌的治疗的方法之间进行区分的方法。 因此本发明涉及一种工具，用于执行上述方法，：如诊断装置。

公开(公告)号：EP3084443B1

公开(公告)日：2018-08-22

申请号：EP14815751.4

申请日：2014-12-19

申请人： metanomics Health GmbH

发明人： KAMLAGE, Beate ,  RESZKA, Regina ,  PETER, Erik ,  KASTLER, Jürgen ,  SCHATZ, Philipp ,  KALTHOFF, Holger ,  SCHNIEWIND, Bodo ,  MAYERLE, Julia ,  LERCH, Markus ,  PILARSKY, Christian ,  GRÜTZMANN, Robert

IPC分类号： G01N33/574

CPC分类号： G01N33/57438 ,  G01N33/49 ,  G01N33/92 ,  G01N2400/00 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08

摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreas cancer in a subject and, preferably for differentiating between pancreatic cancer and pancreatitis and a method for identifying whether a subject is in need for a therapy of pancreatic cancer. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

公开(公告)号：EP2786152B1

公开(公告)日：2019-01-02

申请号：EP12799110.7

申请日：2012-11-29

申请人： metanomics Health GmbH

发明人： RESZKA, regina ,  KAMLAGE, Beate ,  KALTHOFF, Holger ,  SCHNIEWIND, Bodo ,  MAYERLE, Julia ,  LERCH, Markus M. ,  PILARSKY, Christian ,  GRÜTZMANN, Robert

IPC分类号： G01N33/574

公开(公告)号：EP3314264A1

公开(公告)日：2018-05-02

申请号：EP16732596.8

申请日：2016-06-24

申请人： metanomics Health GmbH

发明人： KAMLAGE, Beate ,  RESZKA, Regina ,  SCHATZ, Philipp ,  DOSTLER, Martin ,  CARVALHO, Susan ,  PETER, Erik ,  MAPPES, Philipp ,  KALTHOFF, Holger ,  SCHNIEWIND, Bodo ,  MAYERLE, Julia ,  LERCH, Markus ,  GRUETZMANN, Robert ,  PILARSKY, Christian

IPC分类号： G01N33/574 ,  G01N33/68

CPC分类号： G01N33/57438 ,  G01N33/6806 ,  G01N33/6812 ,  G01N2405/08 ,  G01N2800/60 ,  G01N2800/7028 ,  G01N2800/7076 ,  G01N2800/7085

摘要： The present invention relates to a method for diagnosing pancreatic cancer in a subject comprising the steps of: (a) determining in at least one sample of said subject the amounts of a group of diagnostic biomarkers comprising (i) at least one diagnostic amino acid, said diagnostic amino acid being proline, histidine or tryptophan, preferably, being proline; (ii) at least one diagnostic ceramide, said diagnostic ceramide being ceramide (d18:1,C24:0) or ceramide (d18:2,C24:0), preferably being ceramide (d18:1,C24:0); (iii) at least one diagnostic sphingomyelin, said diagnostic sphingomyelin being sphingomyelin (35:1), sphingomyelin (d17:1,C16:0), sphingomyelin (41:2) or sphingomyelin (d18:2,C17:0), preferably being sphingomyelin (35:1); and (iv) CA19-9; and (b) comparing said amounts of the diagnostic biomarkers with a reference, whereby pancreatic cancer is diagnosed. Moreover, the present invention relates to a method for determining the probability for a subject to suffer from pancreatic cancer, and to devices and uses related to said methods.

公开(公告)号：EP2786152A1

公开(公告)日：2014-10-08

申请号：EP12799110.7

申请日：2012-11-29

申请人： metanomics Health GmbH

发明人： RESZKA, regina ,  KAMLAGE, Beate ,  KALTHOFF, Holger ,  SCHNIEWIND, Bodo ,  MAYERLE, Julia ,  LERCH, Markus M. ,  PILARSKY, Christian ,  GRÜTZMANN, Robert

IPC分类号： G01N33/574

CPC分类号： G01N33/57438 ,  G01N2033/57461

摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreatic cancer in a subject, a method for identifying whether a subject is in need for a therapy of pancreatic cancer or a method for determining whether a pancreatic cancer therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

摘要翻译： 本发明涉及诊断方法领域。 具体而言，本发明设想了用于诊断受试者胰腺癌的方法，用于鉴定受试者是否需要胰腺癌治疗的方法或用于确定胰腺癌疗法是否成功的方法。 本发明还涉及用于执行上述方法的工具，诸如诊断装置。