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    METHODS FOR DIAGNOSING PANCREATIC CANCER
    4.
    发明公开
    METHODS FOR DIAGNOSING PANCREATIC CANCER 审中-公开

    公开(公告)号：EP3502699A1

    公开(公告)日：2019-06-26

    申请号：EP17209024.3

    申请日：2017-12-20

    申请人： metanomics Health GmbH ,  Universitätsmedizin Greifswald

    发明人： KAMLAGE, Beate ,  CHRISTIANSEN, Nicole ,  SCHATZ, Philipp ,  PILARSKY, Christian ,  GRUETZMANN, Robert ,  BAHRA, Marcus ,  MAYERLE, Julia ,  LERCH, Markus ,  CHROMIK, Ansgar Michael

    IPC分类号： G01N33/574 ,  G01N33/68

    摘要： The present invention relates to a method for diagnosing pancreatic cancer in a subject suspected to suffer from pancreatic cancer comprising the steps of: (a) determining in a sample of said subject the value of (i) at least one biomarker of the categories carnitines, amino acids, and mitochondrial energy metabolites, and (ii) a first and a second sphingolipid, wherein the fatty acid residue of the first sphingolipid is at least four carbon atoms longer than the fatty acid residue of the second sphingolipid, and wherein the sphingosine backbone of the first sphingolipid and the second sphingolipid are identical; and (b) comparing the values of the biomarkers with references, whereby pancreatic cancer is diagnosed; and to a method for identifying whether a subject is in need of a pancreatic cancer therapy related thereto. The present invention further relates to a device for diagnosing pancreatic cancer in a sample of a subject comprising (a) an analyzing unit for the sample of the subject comprising a detector for the amounts of at least one biomarker each of the categories carnitines, amino acids, energy metabolites, and sphingolipids; said detector allowing for the determination of the amounts of the biomarkers of the said group of biomarkers in the sample; and operatively linked thereto, (b) an evaluation unit comprising a data processing unit and a data base, said data base comprising a stored reference and said data processing unit having tangibly embedded an algorithm for carrying out a comparison of the amounts of the biomarkers of the group of biomarkers determined by the analyzing unit and the stored reference and for generating an output information based on which the diagnosis can be established. Further, the present invention relates to a data collection and too a use related to the aforesaid subject matter.

    DEVICE AND METHODS TO DIAGNOSE PANCREATIC CANCER
    9.
    发明公开
    DEVICE AND METHODS TO DIAGNOSE PANCREATIC CANCER 审中-公开
    诊断胰腺癌的装置和方法

    公开(公告)号：EP2786152A1

    公开(公告)日：2014-10-08

    申请号：EP12799110.7

    申请日：2012-11-29

    申请人： metanomics Health GmbH

    发明人： RESZKA, regina ,  KAMLAGE, Beate ,  KALTHOFF, Holger ,  SCHNIEWIND, Bodo ,  MAYERLE, Julia ,  LERCH, Markus M. ,  PILARSKY, Christian ,  GRÜTZMANN, Robert

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57438 ,  G01N2033/57461

    摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreatic cancer in a subject, a method for identifying whether a subject is in need for a therapy of pancreatic cancer or a method for determining whether a pancreatic cancer therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

    摘要翻译： 本发明涉及诊断方法领域。 具体而言，本发明设想了用于诊断受试者胰腺癌的方法，用于鉴定受试者是否需要胰腺癌治疗的方法或用于确定胰腺癌疗法是否成功的方法。 本发明还涉及用于执行上述方法的工具，诸如诊断装置。