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    MEANS AND METHODS FOR DIAGNOSING PROSTATE CARCINOMAS
    6.
    发明公开
    MEANS AND METHODS FOR DIAGNOSING PROSTATE CARCINOMAS 有权
    方法前列腺癌的诊断

    公开(公告)号：EP2438445A1

    公开(公告)日：2012-04-11

    申请号：EP10724454.3

    申请日：2010-06-02

    申请人： Metanomics Health GmbH ,  Charité Universitätsmedizin Berlin

    发明人： KAMLAGE, Beate ,  BETHAN, Bianca ,  RESZKA, Regina ,  LEIBOLD, Edgar ,  JUNG, Klaus ,  LEIN, Michael ,  KRISTIANSEN, Glen

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57484 ,  G01N33/57434

    摘要： The present invention relates to a method, preferably an ex vivo method, for diagnosing prostate carcinomas and/or predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from prostate carcinomas or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby prostate carcinomas or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metaboiite and the use of said at least one metabolite for the manufacture of diagnostic means for or for diagnosing prostate carcinomas. Finally, the present invention pertains to a method for identifying prostate carcinoma-related metabolites.

    MEANS AND METHODS FOR DIAGNOSING RECURRENCE OF PROSTATE CANCER AFTER PROSTATECTOMY
    10.
    发明公开
    MEANS AND METHODS FOR DIAGNOSING RECURRENCE OF PROSTATE CANCER AFTER PROSTATECTOMY 有权
    手段和方法诊断疾病对前列腺切除后前列腺癌复苏

    公开(公告)号：EP2904397A1

    公开(公告)日：2015-08-12

    申请号：EP13771159.4

    申请日：2013-10-02

    申请人： metanomics Health GmbH ,  Charite - Universitätsmedizin Berlin

    发明人： RESZKA, Regina ,  KAMLAGE, Beate ,  BETHAN, Bianca ,  JUNG, Klaus ,  LEIN, Michael ,  KRISTIANSEN, Glen ,  STEPHAN, Carsten

    IPC分类号： G01N33/574

    CPC分类号： G01N33/4833 ,  G01N33/57434 ,  G01N2560/00 ,  G01N2570/00 ,  G01N2800/342 ,  G01N2800/54 ,  G06F19/12 ,  G16H50/20

    摘要： The present invention concerns means and methods for cancer diagnosis and, in particular, diagnosis of prostate cancer. Specifically, it relates to a method for diagnosing whether a subject is at risk for recunent prostate carcinoma after prostatectomy comprising determining the amount of at least one metabolite selected from Table 2 in a test sample of a subject after prostatectomy, and comparing the determined amount to a reference, whereby it is diagnosed whether the subject is at risk for recurrent prostate carcinoma after prostatectomy. Further methods provided in accordance with the present invention relate to differentiating between a malignant prostate carcinoma tissue and a non-malignant tissue and diagnosing metastasizing prostate carcinoma in a subject. Also provided are devices for carrying out the aforementioned methods.

    摘要翻译： 本发明涉及的手段和用于癌症诊断的方法，特别是，前列腺癌的诊断。 具体地，它涉及一种用于诊断受试者是否是在前列腺切除术后风险recunent前列腺癌包括确定性采矿至少一种代谢物的前列腺切除术后的受试者的测试样品中选自表2的量，并且确定性开采量进行比较来 基准，由此诊断是否受试者处于前列腺切除术后复发的前列腺癌的风险。 在雅舞蹈设置有本发明进一步方法涉及一种恶性前列腺癌组织和非恶性组织之间进行区分和诊断受试者转移性前列腺癌。 因此，提供了用于实施上述方法的设备。