公开(公告)号：EP2024347A1

公开(公告)日：2009-02-18

申请号：EP07724733.6

申请日：2007-04-30

申请人： sanofi-aventis

发明人： DEFOSSA, Elisabeth ,  FOLLMANN, Markus ,  KLABUNDE, Thomas ,  DROSOU, Viktoria ,  HESSLER, Gerhard ,  STENGELIN, Siegfried ,  HASCHKE, Guido ,  HERLING, Andreas ,  BARTOSCHEK, Stefan

IPC分类号： C07D263/58 ,  C07D413/12 ,  A61K31/423 ,  A61P3/06 ,  A61P3/10

CPC分类号： A61K31/423 ,  A61K45/06 ,  C07D263/58 ,  C07D413/12

摘要： The invention relates to phenylamino-benzoxazole substituted carboxylic acids and to their physiologically compatible salts. The invention also relates to compounds of formula (I), wherein R1, R2, R6, R7, R8, R9, R10, m and X are defined as in the description, and to their physiologically compatible salts. Said compounds are suitable, for example, for the treatment of diabetes.

公开(公告)号：EP1781656A2

公开(公告)日：2007-05-09

申请号：EP05792575.2

申请日：2005-08-16

申请人： Sanofi-Aventis Deutschland GmbH

发明人： SCHWINK, Lothar ,  STENGELIN, Siegfried ,  GOSSEL, Matthias ,  HESSLER, Gerhard ,  LENNIG, Petra

IPC分类号： C07D471/04 ,  C07D487/08 ,  C07D487/04 ,  A61K31/407 ,  A61K31/437 ,  A61K31/4375 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： The invention relates to aryl-substituted polycyclic amines of formula I, particularly bicyclic amines, and the physiologically acceptable salts and physiologically functional derivatives thereof, the symbols and radicals being defined as indicated in the description.

摘要翻译： 本发明涉及式I的芳基取代的多环胺，特别是双环胺，及其生理学上可接受的盐和生理学上的功能衍生物，其符号和基团如说明书中所定义。

公开(公告)号：EP1711494B1

公开(公告)日：2010-06-09

申请号：EP05701163.7

申请日：2005-01-25

申请人： Sanofi-Aventis Deutschland GmbH

发明人： SCHWINK, Lothar ,  STENGELIN, Siegfried ,  BOEHME, Thomas ,  GOSSEL, Matthias ,  HESSLER, Gerhard ,  LENNIG, Petra

IPC分类号： C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  C07D417/10 ,  C07D491/113 ,  A61K31/4245 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D491/10 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14

摘要： The invention relates to substituted, aryl-substituted heterocycles, the physiologically-acceptable salts and physiologically-functional derivatives thereof, methods for production and use thereof as medicaments. Compounds of formula (I), where the groups have the given meanings, the N-oxides and physiologically-acceptable salts thereof and methods for production thereof are disclosed. The compounds exhibit, for example a weight-reducing effect in mammals and are thus suitable for use in, for example, prevention and treatment of obesity and diabetes. Said compounds are MCH receptor antagonists.

公开(公告)号：EP1781656B1

公开(公告)日：2007-12-19

申请号：EP05792575.2

申请日：2005-08-16

申请人： Sanofi-Aventis Deutschland GmbH

发明人： SCHWINK, Lothar ,  STENGELIN, Siegfried ,  GOSSEL, Matthias ,  HESSLER, Gerhard ,  LENNIG, Petra

IPC分类号： C07D471/04 ,  C07D487/08 ,  C07D487/04 ,  A61K31/407 ,  A61K31/437 ,  A61K31/4375 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： The invention relates to aryl-substituted polycyclic amines of formula I, particularly bicyclic amines, and the physiologically acceptable salts and physiologically functional derivatives thereof, the symbols and radicals being defined as indicated in the description.

公开(公告)号：EP1781663A2

公开(公告)日：2007-05-09

申请号：EP05777343.4

申请日：2005-08-16

申请人： Sanofi-Aventis Deutschland GmbH

发明人： SCHWINK, Lothar ,  STENGELIN, Siegfried ,  GOSSEL, Matthias ,  HESSLER, Gerhard ,  LENNIG, Petra

IPC分类号： C07D487/04 ,  C07D487/10 ,  C07D498/10 ,  A61K31/407 ,  A61K31/424 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： The invention relates to aryl-substituted polycyclic amines of formula (I), particularly bicyclic amines, and the physiologically acceptable salts and physiologically functional derivatives thereof, the symbols and radicals being defined as indicated in the description.

公开(公告)号：EP2238128A2

公开(公告)日：2010-10-13

申请号：EP08864841.5

申请日：2008-12-12

申请人： Sanofi-Aventis

发明人： NAZARÉ, Marc ,  ZECH, Gernot ,  JUST, Melitta ,  WEISS, Tilo ,  HESSLER, Gerhard ,  KOHLMANN, Markus

IPC分类号： C07D403/14 ,  A61K31/496 ,  A61P7/02

CPC分类号： C07D403/14

摘要： The present invention relates to compounds of the formula (I), wherein R1; R2; Z; A; B; D; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus an anti-thrombotic effect and are suitable e.g. for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are reversible antagonists of the platelet ADP receptor P2Y12, and can in general be applied in conditions in which an undesired activation of the platelet ADP receptor P2Y12 is present or for the cure or prevention of which an inhibition of the platelet ADP receptor P2Y12 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

摘要翻译： 本发明涉及式（I）的化合物，其中R 1， R2; Z者除外; 一个; B; d; Q; 焦耳; V; G和M具有权利要求中所指的含义。 式I化合物是有价值的药理活性化合物。 它们对血小板表现出强烈的抗聚集作用，因此具有抗血栓形成作用，并且适用于例如血栓形成。 用于治疗和预防心血管疾病如血栓栓塞性疾病或再狭窄。 它们是血小板ADP受体P2Y12的可逆拮抗剂，并且通常可以用于存在不希望的血小板ADP受体P2Y12激活的病症或用于治疗或预防血小板ADP受体P2Y12抑制的病症 。 本发明还涉及制备式（I）化合物的方法，其用途，特别是作为药物中的活性成分，以及包含它们的药物制剂。

公开(公告)号：EP1987020A1

公开(公告)日：2008-11-05

申请号：EP07711518.6

申请日：2007-02-13

申请人： Sanofi-Aventis

发明人： SCHWINK, Lothar ,  STENGELIN, Siegfried ,  GOSSEL, Matthias ,  HESSLER, Gerhard ,  HAACK, Torsten ,  LENNIG, Petra

IPC分类号： C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D491/04 ,  C07D495/04 ,  C07D498/10 ,  A61P3/10 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/4725

CPC分类号： A61K31/4725 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： The invention relates to azacyclyl-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the azacyclyl-substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.

摘要翻译： 本发明涉及azacyclyl取代aryldihydroisoquinolinones和它们的衍生物，和它们的生理学上可耐受的盐和生理学功能衍生物，它们的制备，包含本发明或它的衍生物中的至少一种azacyclyl取代aryldihydroisoquinolinone药物，以及使用azacyclyl取代aryldihydroisoquinolinones的 作为MCH拮抗剂的本发明及其衍生物。

公开(公告)号：EP1986646A1

公开(公告)日：2008-11-05

申请号：EP07722801.3

申请日：2007-02-13

申请人： Sanofi-Aventis

发明人： SCHWINK, Lothar ,  STENGELIN, Siegfried ,  GOSSEL, Matthias ,  HESSLER, Gerhard ,  HAACK, Torsten ,  LENNIG, Petra

IPC分类号： A61K31/4355 ,  A61K31/4365 ,  A61K31/517 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  C07D239/91 ,  C07D403/10 ,  C07D491/04 ,  C07D495/04

CPC分类号： C07D491/04 ,  C07D239/91 ,  C07D403/10 ,  C07D495/04 ,  C12N9/99

摘要： The invention relates to azacyclyl-substituted arylthienopyrimidinones and their derivatives of formula (I), and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the azacyclyl-substituted aryithienopyrimidinones of the invention and their derivatives as MCH antagonists.

公开(公告)号：EP1711494A1

公开(公告)日：2006-10-18

申请号：EP05701163.7

申请日：2005-01-25

申请人： Sanofi-Aventis Deutschland GmbH

发明人： SCHWINK, Lothar ,  STENGELIN, Siegfried ,  BOEHME, Thomas ,  GOSSEL, Matthias ,  HESSLER, Gerhard ,  STAHL, Petra

IPC分类号： C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  C07D417/10 ,  C07D491/113 ,  A61K31/4245 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D491/10 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14

摘要： The invention relates to substituted, aryl-substituted heterocycles, the physiologically-acceptable salts and physiologically-functional derivatives thereof, methods for production and use thereof as medicaments. Compounds of formula (I), where the groups have the given meanings, the N-oxides and physiologically-acceptable salts thereof and methods for production thereof are disclosed. The compounds exhibit, for example a weight-reducing effect in mammals and are thus suitable for use in, for example, prevention and treatment of obesity and diabetes. Said compounds are MCH receptor antagonists.

公开(公告)号：EP1551810B1

公开(公告)日：2011-11-30

申请号：EP03771060.5

申请日：2003-07-18

申请人： Sanofi-Aventis Deutschland GmbH

发明人： SCHWINK, Lothar ,  STENGELIN, Siegfried ,  GOSSEL, Matthias ,  BOEHME, Thomas ,  HESSLER, Gerhard ,  ROSSE, Gerard ,  WALSER, Armin

IPC分类号： C07D233/70 ,  C07D233/32 ,  C07D243/04 ,  C07D249/12 ,  A61K31/4166 ,  A61P3/04 ,  A61P3/10 ,  C07D401/12 ,  C07D209/02 ,  C07D491/10 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/08

CPC分类号： C07D233/92 ,  C07D209/02 ,  C07D233/32 ,  C07D233/70 ,  C07D233/74 ,  C07D233/94 ,  C07D243/04 ,  C07D249/12 ,  C07D401/12 ,  C07D403/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/10 ,  C07D409/12 ,  C07D417/12 ,  C07D487/08 ,  C07D491/10

摘要： The invention relates to substituted diaryl heterocycles and the physiologically compatible salts and physiologically functional derivatives thereof. The invention also relates to compounds of formula (I) wherein the radicals have the cited designations, to the physiologically compatible salts thereof, and to methods for producing the same. Said compounds are suitable, for example, as anorexiants.