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1.发明公开
公开(公告)号：EP2114937A1
公开(公告)日：2009-11-11
申请号：EP08706994.4
申请日：2008-01-11
申请人： Sanofi-Aventis
发明人： KEIL, Stefanie , DEFOSSA, Elisabeth , SCHOENAFINGER, Karl , SCHMOLL, Dieter , DIETRICH, Axel , KUHLMANN, Johanna , ENGEL, Karl-Christian
IPC分类号： C07D417/14 , A61K31/5415 , A61P3/10 , C07D417/12 , C07D513/04
CPC分类号： C07D417/12 , C07D417/14 , C07D513/04
摘要： The invention relates to compounds of the formula (I), wherein the radicals R1, R2, R3, R4, R5, R6 and R7 and A and B are defined as indicated, and also to the physiologically tolerable salts thereof. The compounds are suited, for example, as anti-diabetics.
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2.发明授权
公开(公告)号：EP1523471B1
公开(公告)日：2009-09-16
申请号：EP03740386.2
申请日：2003-06-30
发明人： DEFOSSA, Elisabeth , KADEREIT, Dieter , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , WENDT, Karl-Ulrich , VON ROEDERN, Erich , SCHOENAFINGER, Karl
IPC分类号： C07C275/54 , C07D239/96 , A61K31/17 , A61P3/10
CPC分类号： C07D295/135 , C07C275/54 , C07D239/96
摘要： The invention relates to urea-substituted and urethane-substituted acylureas, to physiologically compatible salts thereof and to their physiologically functional derivatives. The invention thus relates to compounds of formula (I), wherein the radicals have the cited meanings. The invention also relates to the physiologically compatible salts of these compounds and to methods for the production thereof. The inventive compounds are suited for use, for example, as antidiabetics.
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3.发明授权4,5-DIPHENYL-PYRIMIDINYL SUBSTITUIERTE CARBONSÄUREN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权4,5-二苯基嘧啶基取代的羧酸，其制造方法相同，并且它们作为药物
公开(公告)号：EP2024338B1
公开(公告)日：2009-09-02
申请号：EP07724732.8
申请日：2007-04-30
申请人： Sanofi-Aventis
发明人： DEFOSSA, Elisabeth , GOERLITZER, Jochen , KLABUNDE, Thomas , DROSOU, Viktoria , STENGELIN, Siegfried , HASCHKE, Guido , HERLING, Andreas , BARTOSCHEK, Stefan
IPC分类号： C07D239/26 , A61K31/505 , A61P3/10 , A61P3/06
CPC分类号： C07D239/26
摘要： The invention relates to 4,5-diphenyl-pyrimidinyl substituted carboxylic acids and to their physiologically compatible salts. The invention also relates to compounds of formula (I), wherein Rl, R2, n, m, and X are defined as cited in the description, and to their physiologically compatible salts. Said compounds are suitable, for example, for the treatment of diabetes.
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4.发明公开4,5-DIPHENYL-PYRIMIDINYL-OXY ODER -MERCAPTO SUBSTITUIERTE CARBONSÄUREN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权4,5-二苯基嘧啶基氧代或巯基取代的羧酸，其制造方法相同，并且它们作为药物
公开(公告)号：EP2024339A1
公开(公告)日：2009-02-18
申请号：EP07724730.2
申请日：2007-04-30
申请人： Sanofi-Aventis
发明人： DEFOSSA, Elisabeth , GOERLITZER, Jochen , KLABUNDE, Thomas , DROSOU, Viktoria , STENGELIN, Siegfried , HASCHKE, Guido , HERLING, Andreas , BARTOSCHEK, Stefan
IPC分类号： C07D239/34 , A61K31/513 , A61P3/10
CPC分类号： C07D239/34
摘要： The invention relates to 4,5-diphenyl-pyrimidinyl-oxy or -mercapto substituted carboxylic acids and to their physiologically compatible salts. The invention also relates to compounds of formula (I), wherein Rl, R2, n, m, V, W, X and Y are defined as cited in the description, and to their physiologically compatible salts. Said compounds are suitable, for example, for the treatment of diabetes.
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5.发明公开SUBSTITUIERTE, BIZYKLISCHE 8-PYRROLIDINO-BENZIMIDAZOLE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权取代的双环8吡咯苯并咪唑类，制造方法相同，它们作为药物
公开(公告)号：EP1863817A1
公开(公告)日：2007-12-12
申请号：EP06723254.6
申请日：2006-03-07
申请人： sanofi-aventis
发明人： DEFOSSA, Elisabeth , SCHOENAFINGER, Karl , JAEHNE, Gerhard , BUNNING, Christian , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07D487/04 , A61P3/00 , A61P9/00 , A61K31/4184
CPC分类号： C07D487/04
摘要： The invention relates to substituted, bicyclic 8-pyrrolidino-benzimidazoles, in addition to the physiologically compatible salts and physiologically functional derivatives of said compounds. The invention relates to compounds of formula (I), in which the groups are defined as cited in the description and to the physiologically compatible salts of said compounds. The compounds are suitable for use, for example, as medicaments for the prevention and treatment of type 2 diabetes.
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6.发明公开HETEROCYCLISCH SUBSTITUIERTE 7-AMINO-4-CHINOLON-3-CARBONSÄURE-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权杂环取代的7-氨基-4-喹诺酮-3-羧酸衍生物，METHOD FOR它们的生产和它们作为药物
公开(公告)号：EP1720870A1
公开(公告)日：2006-11-15
申请号：EP05700959.9
申请日：2005-01-15
发明人： DEFOSSA, Elisabeth , KADEREIT, Dieter , RUF, Sven , KLABUNDE, Thomas , SCHMOLL, Dieter , HERLING, Andreas , WENDT, Karl-Ulrich
IPC分类号： C07D471/04 , C07D401/12 , A61K31/4375 , A61K31/47 , A61P3/10
CPC分类号： C07D417/12 , C07D215/56 , C07D401/12 , C07D471/04
摘要： The invention relates to heterocyclically substituted 7-amino-4-quinolone-3-carboxylic acid derivatives as well as their physiologically compatible salts and physiologically functional derivatives. The invention concerns compounds of formula (I), wherein the radicals have the cited meanings, and the physiologically compatible salts thereof. The compounds are suited for use, e.g. as medicaments for preventing and treating type 2 diabetes.
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7.发明公开SUBSTITUIERTE BENZOYLUREIDOPYRIDYL-PIPERIDIN- UND -PYRROLIDIN-CARBONS UREDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN V ERWENDUNG 有权取代BENZOYLUREIDOPYRIDYL - 哌啶和吡咯烷 - 碳酸衍生物，METHOD FOR上述其ùSE
公开(公告)号：EP1603895A1
公开(公告)日：2005-12-14
申请号：EP04713467.1
申请日：2004-02-21
发明人： SCHOENAFINGER, Karl , KADEREIT, Dieter , DEFOSSA, Elisabeth , HERLING, Andreas , KLABUNDE, Thomas
IPC分类号： C07D401/04 , A61K31/444
CPC分类号： C07D401/04
摘要： The invention relates to substituted benzoylureidopyridyl-piperidine and -pyrrolidine carboxylic acid derivatives, to a method for the production thereof, and to their use. The invention concerns both compounds of formula (I), wherein the radicals have the cited meanings, as well as physiologically compatible salts of said compounds. These compounds are suited for use as, e.g. medicaments for preventing and treating Type 2 diabetes.
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8.发明授权SUBSTITUIERTE 2-AMINOALKYLTHIO-BENZIMIDAZOLE UND IHRE VERWENDUNG ZUR BLUTZUCKERSENKUNG 有权取代的2-氨基烷，苯并咪唑和它们用于降低血糖
公开(公告)号：EP1874737B1
公开(公告)日：2010-08-04
申请号：EP06723959.0
申请日：2006-04-01
申请人： sanofi-aventis
发明人： DEFOSSA, Elisabeth , SCHOENAFINGER, Karl , JAEHNE, Gerhard , BUNING, Christian , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07D235/28 , A61K31/4184 , A61P3/10
CPC分类号： C07D235/28
摘要： The invention relates to substituted 2-aminoalkylthio-benzimidazoles, in addition to the physiologically compatible salts thereof and physiologically functional derivatives thereof. The invention also relates to compounds of formula (I), wherein the radicals have the above-mentioned meaning, and the physiologically compatible salts thereof. Said compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
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9.发明授权ACYL-4-CARBOXY-PHENYL-HARNSTOFFDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权酰基4-羧基苯基脲衍生物，用于生产及其用途
公开(公告)号：EP1497262B1
公开(公告)日：2010-08-04
申请号：EP03712111.8
申请日：2003-03-28
发明人： DEFOSSA, Elisabeth , KADEREIT, Dieter , SCHOENAFINGER, Karl , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , WENDT, Karl-Urlich , VON ROEDERN, Erich , ENHSEN, Alfons , RIEKE-ZAPP, Joerg
IPC分类号： C07C275/54 , C07D295/12 , A61K31/17 , A61P7/12
CPC分类号： C07D295/155 , C07C275/54
摘要： The invention relates to acyl-4-carboxyphenylurea derivatives, the physiologically-acceptable salts, physiologically-functional derivatives thereof and compounds of formula (I), where the groups have the given meanings, the physiologically acceptable salts and method for production thereof. Said compounds are suitable, for example, as anti-diabetics.
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10.发明授权
公开(公告)号：EP1523475B1
公开(公告)日：2009-12-23
申请号：EP03763692.5
申请日：2003-07-03
发明人： SCHOENAFINGER, Karl , DEFOSSA, Elisabeth , KADEREIT, Dieter , VON ROEDERN, Erich , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , WENDT, Karl-Ulrich
IPC分类号： C07D211/62 , C07D249/08 , C07D257/04 , C07D271/10 , C07D253/06 , C07D231/26 , C07D307/68 , C07D235/18 , A61K31/17 , A61P3/10
CPC分类号： C07D211/60 , C07D211/62 , C07D231/12 , C07D231/26 , C07D233/56 , C07D235/18 , C07D249/08 , C07D249/12 , C07D253/07 , C07D257/04 , C07D271/10 , C07D271/113 , C07D307/68
摘要： The invention relates to heterocyclically substituted benzoylureas, in addition to their physiologically compatible salts and physiologically functional derivatives. The invention relates in particular to compounds of formula (I), in which the groups are defined as cited in the description, in addition to their physiologically compatible salts and to a method for producing said compounds. The compounds are suitable e.g. for treating type 2 diabetes.
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