利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

37 条记录 (耗时 0.015 秒)

    METHODS AND COMPOSITIONS COMPRISING NON-PEPTIDE SMALL MOLECULES THAT SOLUBILIZE BETA AMYLOID PEPTIDE FIBER
    4.
    发明公开
    METHODS AND COMPOSITIONS COMPRISING NON-PEPTIDE SMALL MOLECULES THAT SOLUBILIZE BETA AMYLOID PEPTIDE FIBER 审中-公开
    方法和非肽类小分子的组合物含β淀粉样肽纤维溶解

    公开(公告)号：EP1725224A4

    公开(公告)日：2009-06-24

    申请号：EP05723374

    申请日：2005-02-18

    申请人： AC IMMUNE SA

    发明人： NICOLAU YVES CLAUDE ,  ELISEEV ALEXEY ,  LEHN JEAN-MARIE

    IPC分类号： A61K38/04 ,  A61K31/015 ,  G01N33/68

    CPC分类号： G01N33/6896 ,  A61K31/015 ,  G01N2333/4709 ,  G01N2500/04 ,  G01N2800/2821

    摘要： The present invention comprises novel compositions and methods for the treatment of neurological diseases associated with beta amyloid peptide. In particular, the present invention is directed to Aß fiber solubilization, for the treatment of amyloid-associated diseases such as Alzheimer's disease, and is described herein as being achieved by using small molecules binding to Aß fiber. The present invention further comprises novel methods of designing and screening compositions for the treatment of neurological disease wherein the design aspect comprises the modeling of molecular scaffolds having optimal structural characteristics that enable the development of small molecule compositions of non-peptide nature having desirable solubilization effects on amyloid plaques. In one embodiment, the design of the compounds comprises a molecular structure with three chemical domains that include a melatonin-like domain, a nicotine-like domain and a peptide-like domain for binding to Aß.