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公开(公告)号：EP4146653A1
公开(公告)日：2023-03-15
申请号：EP21723288.3
申请日：2021-05-07
申请人： AC Immune SA
发明人： MOLETTE, Jérôme
IPC分类号： C07D487/04 , A61K31/4162 , A61K51/00
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公开(公告)号：EP3988566A1
公开(公告)日：2022-04-27
申请号：EP21191801.6
申请日：2007-07-13
申请人： AC Immune SA , GENENTECH, INC.
摘要： The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.
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公开(公告)号：EP3978517A1
公开(公告)日：2022-04-06
申请号：EP21180474.5
申请日：2010-03-18
申请人： AC Immune SA
发明人： Pfeifer, Andrea , Muhs, Andreas , Pihlgren, Maria
IPC分类号： C07K14/47 , A61P25/28 , A61K39/00 , A61P3/10 , A61P21/02 , A61P25/00 , A61P25/16 , A61P27/02 , A61P27/06 , A61P35/00 , A61P37/02 , A61P37/04 , A61P31/18
摘要： The present invention relates to an antigenic composition comprising an adjuvant and a tau peptide antigen modified by four palmitic acid moieties inserted into the lipid bilayer of a liposome and presented in a highly repetitive array on the surface of the liposome, for use in the treatment of a tau-associated disease or disorder, in a patient having a T-cell deficiency, wherein
(i) the tau peptide is the peptide shown in SEQ ID NO:5; and
(ii) the adjuvant is MPLA.-
公开(公告)号：EP3802533A1
公开(公告)日：2021-04-14
申请号：EP19730702.8
申请日：2019-05-30
申请人： AC Immune SA
IPC分类号： C07D471/04 , C07D471/14 , C07D519/00 , A61P25/00 , A61K31/437 , A61K31/444 , A61K31/496
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公开(公告)号：EP3743426A1
公开(公告)日：2020-12-02
申请号：EP19700950.9
申请日：2019-01-22
发明人： BERNDT, Mathias , MÜLLER, Andre , ODEN, Felix , SCHIEFERSTEIN, Hanno , SCHMITT-WILLICH, Heribert , KROTH, Heiko , MOLETTE, Jérôme , GABELLIERI, Emanuele , BOUDOU, Cédric
IPC分类号： C07D471/14 , A61K51/04 , C07B59/00
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公开(公告)号：EP2836499B1
公开(公告)日：2020-02-26
申请号：EP13775926.2
申请日：2013-04-12
发明人： SHAW, Walter A. , BURGESS, Stephen W , LI, Shengrong , HICKMAN, David T , LOPEZ-DEBER, Maria Pilar
IPC分类号： A61K31/7016 , A61K8/14 , A61K39/39
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7.发明公开METHODS AND COMPOSITIONS COMPRISING NON-PEPTIDE SMALL MOLECULES THAT SOLUBILIZE BETA AMYLOID PEPTIDE FIBER 审中-公开方法和非肽类小分子的组合物含β淀粉样肽纤维溶解
公开(公告)号：EP1725224A4
公开(公告)日：2009-06-24
申请号：EP05723374
申请日：2005-02-18
申请人： AC IMMUNE SA
IPC分类号： A61K38/04 , A61K31/015 , G01N33/68
CPC分类号： G01N33/6896 , A61K31/015 , G01N2333/4709 , G01N2500/04 , G01N2800/2821
摘要： The present invention comprises novel compositions and methods for the treatment of neurological diseases associated with beta amyloid peptide. In particular, the present invention is directed to Aß fiber solubilization, for the treatment of amyloid-associated diseases such as Alzheimer's disease, and is described herein as being achieved by using small molecules binding to Aß fiber. The present invention further comprises novel methods of designing and screening compositions for the treatment of neurological disease wherein the design aspect comprises the modeling of molecular scaffolds having optimal structural characteristics that enable the development of small molecule compositions of non-peptide nature having desirable solubilization effects on amyloid plaques. In one embodiment, the design of the compounds comprises a molecular structure with three chemical domains that include a melatonin-like domain, a nicotine-like domain and a peptide-like domain for binding to Aß.
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公开(公告)号：EP4452972A1
公开(公告)日：2024-10-30
申请号：EP22843797.6
申请日：2022-12-22
申请人： AC Immune SA
IPC分类号： C07D413/04 , C07D413/14 , A61K31/4418 , A61P29/00
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公开(公告)号：EP4430045A1
公开(公告)日：2024-09-18
申请号：EP22822286.5
申请日：2022-11-10
申请人： AC Immune SA
发明人： MOLETTE, Jérôme
IPC分类号： C07D487/04 , A61K31/4162 , A61K51/00
CPC分类号： C07D487/04
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公开(公告)号：EP4229082A1
公开(公告)日：2023-08-23
申请号：EP21787000.5
申请日：2021-10-15
申请人： AC Immune SA
IPC分类号： C07K16/18
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