公开(公告)号：EP3465201A1

公开(公告)日：2019-04-10

申请号：EP17810896.5

申请日：2017-06-06

申请人： Astute Medical, Inc. ,  University of Pittsburgh- Of the Commonwealth System of Higher Education

发明人： MCPHERSON, Paul ,  KAMPF, James, Patrick ,  KELLUM, John, A.

IPC分类号： G01N33/48 ,  G01N33/493 ,  G01N33/50 ,  G01N33/68

公开(公告)号：EP3532101A1

公开(公告)日：2019-09-04

申请号：EP17865610.4

申请日：2017-10-27

申请人： Astute Medical, Inc. ,  University of Pittsburgh- Of the Commonwealth System of Higher Education

发明人： McPHERSON, Paul ,  KELLUM, John, A.

IPC分类号： A61K39/395 ,  A61K39/00 ,  A61K38/00 ,  G01N33/00 ,  C12M3/00

公开(公告)号：EP3077819A1

公开(公告)日：2016-10-12

申请号：EP14868424.4

申请日：2014-12-03

申请人： Astute Medical, Inc. ,  University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： MCPHERSON, Paul ,  KELLUM, John, A.

IPC分类号： G01N33/566

CPC分类号： A61K38/13 ,  A61K31/357 ,  A61K31/366 ,  A61K31/436 ,  A61K31/437 ,  A61K31/453 ,  A61K31/55 ,  A61K31/585 ,  A61K38/1754 ,  A61K38/55 ,  A61K45/06 ,  G01N33/6893 ,  G01N2333/4745 ,  G01N2333/8146 ,  G01N2800/347 ,  G01N2800/50

摘要： It is an object of the present invention to provide methods and compositions for protection of subjects from acute kidney injury by treating the subject with compounds that modulate the cell cycle. Modulating the cell cycle can comprise inducing G
0 /G
1 cell cycle arrest, and/or inducing cell cycle progression. As demonstrated below, even a single administration of a compound which induces G
0 /G
1 cell cycle arrest can protect subjects from AKI, and may be used prophylactically in advance of, or as a treatment following, various treatments or conditions that are known to be injurious to the kidney, followed optionally by release of the arrest. Once AKI is established, cell cycle progression can be induced to increase replacement of lost and damaged cells.

摘要翻译： 它是本发明的一个目的是通过治疗受试者与化合物做调节细胞周期以提供用于从急性肾损伤的受试者的保护方法和组合物。 调节细胞周期可以包括诱导G0 / G1期细胞周期停滞和/或诱导细胞周期进程。 如以下实例阐述，其诱导G0 / G1细胞周期阻滞可以保护受试者从AKI，并且可以提前的预防性使用，或作为治疗以下的化合物的甚至单次给药，各种处理或条件也已知是有害 肾脏，通过逮捕任选发行紧随其后。 一旦AKI被建立，细胞周期进程可以被诱导以增加替换丢失和损坏细胞的

公开(公告)号：EP2668497B1

公开(公告)日：2020-03-25

申请号：EP12739834.5

申请日：2012-01-20

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： SINGBARTL, Kai ,  KELLUM, John, A.

IPC分类号： G01N33/50 ,  G01N33/53 ,  A61M1/14 ,  G01N33/68

公开(公告)号：EP2668497A1

公开(公告)日：2013-12-04

申请号：EP12739834.5

申请日：2012-01-20

申请人： University of Pittsburgh of the Commonwealth System of Higher Education

发明人： SINGBARTL, Kai ,  KELLUM, John, A.

IPC分类号： G01N33/50 ,  G01N33/53 ,  A61M1/14

CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/60

摘要： This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, renal recovery. For example, renal recovery can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring urinary proteins can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury. Alternatively, the invention describes signature protein expression profiles to establish the probability of renal recovery and/or renal non-recovery.

公开(公告)号：EP2619577A2

公开(公告)日：2013-07-31

申请号：EP11827278.0

申请日：2011-09-19

申请人： University of Pittsburgh of the Commonwealth System of Higher Education

发明人： SINGBARTL, Kai ,  KELLUM, John, A.

IPC分类号： G01N33/50 ,  G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/495 ,  G01N2333/70578 ,  G01N2400/40 ,  G01N2800/347 ,  G01N2800/50

摘要： This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring hyaluronic acid, death receptor 5, and/or transforming growth factor β1 can be used to establish the risk of recovery versus non-recovery in patient' s having suffered an acute kidney injury.

公开(公告)号：EP2619577B1

公开(公告)日：2017-08-16

申请号：EP11827278.0

申请日：2011-09-19

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： SINGBARTL, Kai ,  KELLUM, John, A.

IPC分类号： G01N33/50 ,  G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/495 ,  G01N2333/70578 ,  G01N2400/40 ,  G01N2800/347 ,  G01N2800/50