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403 条记录 (耗时 0.027 秒)

    CLAMP AND APPLICATOR
    5.
    发明授权
    CLAMP AND APPLICATOR 有权
    Chuck和施用器械

    公开(公告)号：EP2498692B1

    公开(公告)日：2016-09-21

    申请号：EP10781986.4

    申请日：2010-11-15

    申请人： BTG International Limited

    发明人： WRIGHT, David, Dakin, Iorwerth

    IPC分类号： A61B17/122 ,  A61B17/128

    CPC分类号： A61B17/12013 ,  A61B17/122 ,  A61B17/1285 ,  A61B90/92 ,  A61B2017/00867 ,  A61B2017/00871 ,  A61B2090/0811

    摘要： The present invention provides a surgical clamp comprising a temperature sensitive shape memory material, the clamp capable of taking up a first form in which the clamp (6) is shaped to at least partially encircle a tubular structure (14); a second form shaped to substantially completely encircle the tubular structure (14) and constrict it, the clamp changing from the first form to the second form above the transition temperature of the shape memory material; and a third form derived from the first form by resilient deformation of the clamp in its first form. The present invention also provides applicators for delivering the clamps and kits comprising the clamps.

    Use of Core 2 GlcNac-T inhibitors III for the treatment of inflammatory conditions
    9.
    发明公开
    Use of Core 2 GlcNac-T inhibitors III for the treatment of inflammatory conditions 有权
    使用芯2的GlcNAc-T-III抑制剂在炎症性疾病的治疗

    公开(公告)号：EP2382981A3

    公开(公告)日：2011-12-14

    申请号：EP11163564.5

    申请日：2006-07-06

    申请人： BTG International Limited

    发明人： Chibber, Rakesh

    IPC分类号： A61K31/704 ,  A61K31/7048 ,  A61K31/706 ,  A61P1/04 ,  A61P1/06 ,  A61P1/16 ,  A61P29/00 ,  A61P37/00

    CPC分类号： A61K31/706 ,  A61K31/704 ,  A61K31/7048

    摘要： Treatments for conditions involving detrimental activity of the enzyme core 2 GlcNAc - T are provided using compounds of the formula I

    wherein
    R 1 is H, -OH, C 1-6 alkoxy, -NR 5 R 6 , or Sac 1;
    R 2 is H, -OH, C 1-6 alkoxy or Sac 2;
    R 3 is H, -OH, C 1-6 alkoxy or Sac 3;
    R 4 is H, C 1-6 alkyl, C 1-6 hydroxyalkyl or C 1-6 -alkoxy-C 1-6 -alkyl;
    R 5 is H, C 1-6 alkyl or C 1-6 acyl;
    R 6 is H, C 1-6 alkyl or C 1-6 acyl;
    Sac 1 Sac 2 and Sac 3 are independently selected saccharide moieties; and
    Z is a steroid moiety;
    or a pharmaceutically acceptable salt, ether or ester form thereof, wherein the condition to be treated is an inflammatory condition selected from ileitis, cholitis, cholecystitis, diverticulitis, gastritis, irritable bowel syndrome, inflammatory bowel disease, Lupus and ulcerative cholitis.