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公开(公告)号：EP2781913B1
公开(公告)日：2017-12-13
申请号：EP14161288.7
申请日：2008-09-11
IPC分类号： G01N27/00 , B01D59/44 , G01N33/68 , G01N33/574
CPC分类号： G01N33/6848 , G01N33/57423 , G01N33/6893 , G01N2500/00 , G01N2800/12 , G01N2800/122
摘要： A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known two have non-small cell lung cancers and asthma, as diagnosed by a physician, Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer. Mass spectral data from each population is compared to determine proteins with expression intensities which are significantly differentially expressed between the normal, asthma, and lung cancer populations. Eleven proteins are found to have expression intensities which are significantly differentially expressed between the populations. Finally, the identity of the eleven proteins are obtained by comparing the mass spectral data with known databases having libraries of mass spectral data of known proteins.
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2.发明公开METHODS OF IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF LUNG DISEASES AND KITS THEREOF INCLUDING GENDER-BASED DISEASE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY 审中-公开识别，评估，预防和治疗肺疾病方法和试剂盒THEREFOR性别特定疾病鉴定，评估，预防和治疗
公开(公告)号：EP2406401A2
公开(公告)日：2012-01-18
申请号：EP10751519.9
申请日：2010-03-12
CPC分类号： G01N33/57423 , G01N33/6893 , G01N2800/12
摘要： The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subjects response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
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3.发明公开METHODS OF IDENTIFICATION AND DIAGNOSIS OF LUNG DISEASES USING CLASSIFICATION SYSTEMS AND KITS THEREOF 审中-公开用于识别和肺部疾病诊断方法采用分级系统和试剂盒THEREFOR
公开(公告)号：EP2702411A1
公开(公告)日：2014-03-05
申请号：EP12777309.1
申请日：2012-04-30
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , G01N2800/60 , G06F19/00 , G16H50/20 , G16H50/70
摘要： The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. Measurements of these biomarkers are inputted into a classification system such as a support vector machine or AdaBoost to assist in determining the likelihood that an individual has a lung disease. Kits comprising agents for detecting the biormarkers and combination of biormarkers, as well as systems that assist in diagnosing lung diseases are also provided.
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4.发明公开
公开(公告)号：EP2195645A1
公开(公告)日：2010-06-16
申请号：EP08830503.2
申请日：2008-09-11
CPC分类号： G01N33/6848 , G01N33/57423 , G01N33/6893 , G01N2500/00 , G01N2800/12 , G01N2800/122
摘要： A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known two have non-small cell lung cancers and asthma, as diagnosed by a physician, Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer. Mass spectral data from each population is compared to determine proteins with expression intensities which are significantly differentially expressed between the normal, asthma, and lung cancer populations. Eleven proteins are found to have expression intensities which are significantly differentially expressed between the populations. Finally, the identity of the eleven proteins are obtained by comparing the mass spectral data with known databases having libraries of mass spectral data of known proteins.
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5.发明授权
公开(公告)号：EP2195645B1
公开(公告)日：2014-05-07
申请号：EP08830503.2
申请日：2008-09-11
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/6848 , G01N33/57423 , G01N33/6893 , G01N2500/00 , G01N2800/12 , G01N2800/122
摘要： A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known two have non-small cell lung cancers and asthma, as diagnosed by a physician, Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer. Mass spectral data from each population is compared to determine proteins with expression intensities which are significantly differentially expressed between the normal, asthma, and lung cancer populations. Eleven proteins are found to have expression intensities which are significantly differentially expressed between the populations. Finally, the identity of the eleven proteins are obtained by comparing the mass spectral data with known databases having libraries of mass spectral data of known proteins.
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公开(公告)号：EP3257953B1
公开(公告)日：2018-09-26
申请号：EP17179032.2
申请日：2010-03-12
IPC分类号： C12Q1/68 , C12N15/12 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57423 , G01N33/6893 , G01N2800/12
摘要： The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subject's response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
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7.发明公开METHODS OF IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF LUNG DISEASES AND KITS THEREOF INCLUDING GENDER-BASED DISEASE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY 审中-公开鉴别，评估，预防和治疗肺病及其套件，包括基于性别的疾病识别，评估，预防和治疗
公开(公告)号：EP3257953A1
公开(公告)日：2017-12-20
申请号：EP17179032.2
申请日：2010-03-12
IPC分类号： C12Q1/68 , C12N15/12 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57423 , G01N33/6893 , G01N2800/12
摘要： The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subject's response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
摘要翻译： 本发明提供了用于诊断肺病例如非小细胞肺癌或反应性气道疾病的生物标志物和生物标志物的组合。 本发明还提供了基于生物标志物和生物标志物组合的表达程度，区分肺部疾病的方法，监测治疗方法以及预测受试者对治疗性干预的反应的方法。 还提供了包含用于检测生物标志物和生物标志物组合的试剂盒。
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8.发明公开METHODS OF IDENTIFICATION AND DIAGNOSIS OF LUNG DISEASES USING CLASSIFICATION SYSTEMS AND KITS THEREOF 审中-公开使用分类系统和试剂盒识别和诊断肺部疾病的方法
公开(公告)号：EP3249408A1
公开(公告)日：2017-11-29
申请号：EP17181546.7
申请日：2012-04-30
IPC分类号： G01N33/574 , G06F19/00
CPC分类号： G01N33/57423 , G01N2800/60 , G06F19/00 , G16H50/20 , G16H50/70
摘要： The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. Measurements of these biomarkers are inputted into a classification system such as a support vector machine or AdaBoost to assist in determining the likelihood that an individual has a lung disease. Kits comprising agents for detecting the biormarkers and combination of biormarkers, as well as systems that assist in diagnosing lung diseases are also provided.
摘要翻译： 本发明提供了用于诊断肺病例如非小细胞肺癌或反应性气道疾病的生物标志物和生物标志物的组合。 这些生物标志物的测量被输入到分类系统中，例如支持向量机或AdaBoost，以帮助确定个体患有肺病的可能性。 还提供了包含用于检测生物标志物和生物标志物组合的试剂的试剂盒以及有助于诊断肺病的系统。
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9.发明公开Methods of identification, assessment, prevention and therapy of lung diseases and kits thereof including gender-based disease identification, assessment, prevention and therapy 审中-公开肺疾病及其试剂盒的鉴定，评估，预防和治疗方法，包括基于性别的疾病鉴定，评估，预防和治疗
公开(公告)号：EP2857522A2
公开(公告)日：2015-04-08
申请号：EP14182060.5
申请日：2010-03-12
IPC分类号： C12Q1/68 , C12N15/12 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57423 , G01N33/6893 , G01N2800/12
摘要： The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subject's response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
摘要翻译： 本发明提供了用于诊断肺病例如非小细胞肺癌或反应性气道疾病的生物标志物和生物标志物的组合。 本发明还提供了基于生物标志物和生物标志物组合的表达程度，区分肺部疾病的方法，监测治疗方法以及预测受试者对治疗性干预的反应的方法。 还提供了包含用于检测生物标志物和生物标志物组合的试剂盒。
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10.发明公开
公开(公告)号：EP2781913A2
公开(公告)日：2014-09-24
申请号：EP14161288.7
申请日：2008-09-11
CPC分类号： G01N33/6848 , G01N33/57423 , G01N33/6893 , G01N2500/00 , G01N2800/12 , G01N2800/122
摘要： A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known two have non-small cell lung cancers and asthma, as diagnosed by a physician, Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer. Mass spectral data from each population is compared to determine proteins with expression intensities which are significantly differentially expressed between the normal, asthma, and lung cancer populations. Eleven proteins are found to have expression intensities which are significantly differentially expressed between the populations. Finally, the identity of the eleven proteins are obtained by comparing the mass spectral data with known databases having libraries of mass spectral data of known proteins.
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