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    CHEMICALLY ENCODED SPATIALLY ADDRESSED LIBRARY SCREENING PLATFORMS
    9.
    发明公开
    CHEMICALLY ENCODED SPATIALLY ADDRESSED LIBRARY SCREENING PLATFORMS 审中-公开

    公开(公告)号：EP3650459A1

    公开(公告)日：2020-05-13

    申请号：EP19196019.4

    申请日：2016-02-24

    申请人： City of Hope

    发明人： BERLIN, Jacob ,  COPELAND, Gregory ,  ELISON, Kathleen ,  MURADYAN, Hurik

    IPC分类号： C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C07H21/00 ,  G01N33/543 ,  C40B70/00 ,  B82Y5/00

    摘要： Provided herein are encoded split pool libraries useful, inter alia, for forming highly diverse and dense arrays for screening and detection of a variety of molecules. In particular the application discloses a method comprising:
    (i) providing a solid support comprising a plurality of wells;
    (ii) attaching a plurality of microparticles to said plurality of wells to form an ordered array of a plurality of immobilized microparticles, wherein each of said plurality of immobilized microparticles is further covalently attached to:
    (a) a ligand domain through a first linker; and
    (b) a nucleic acid domain through a second linker;
    wherein said second linker is cleavable and said first linker is not cleavable under a condition that said second linker is cleavable;
    (iii) performing a decoding procedure on the nucleic acid domain, thereby identifying the composition of the ligand domain and its location on said solid support.