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    Device for treating a periodontal disease
    5.
    发明公开
    Device for treating a periodontal disease 审中-公开
    Vorrichtung zur Behandlung von Zahnfleischerkrankung

    公开(公告)号：EP2455064A1

    公开(公告)日：2012-05-23

    申请号：EP11186418.7

    申请日：2011-10-25

    申请人： Dexcel Pharma Technologies Ltd.

    发明人： Avramoff, Avi ,  Shoshani, Eyal ,  Penhasi, Adel ,  Oren, Dan

    IPC分类号： A61K9/00 ,  A61K31/00

    摘要： An oral delivery device for use in treating a periodontal disease affecting a periodontal pocket of a patient. The device is inserted into the periodontal pocket at a frequency of about once every 4 days to about once every 6 weeks. The device is a controlled release solid unit dosage form suitable for insertion into a periodontal pocket of a patient, comprising a therapeutically effective amount of an active ingredient selected from (i) at least one anti-inflammatory agent, (ii) at least one antibacterial agent, and (iii) the combination of at least one anti-inflammatory agent and at least one antibacterial agent.

    摘要翻译： 一种用于治疗影响患者牙周袋的牙周病的口服递送装置。 该装置以每4天约一次的频率插入牙周袋中，每6周约一次。 该装置是适于插入患者牙周袋的控释固体单元剂型，其包含治疗有效量的活性成分，所述活性成分选自（i）至少一种抗炎剂，（ii）至少一种抗细菌剂 试剂，和（iii）至少一种消炎剂和至少一种抗菌剂的组合。

    Specific time-delayed burst profile delivery system
    7.
    发明公开
    Specific time-delayed burst profile delivery system 审中-公开
    系统zur Freisetzung mitverzögertemBursteffekt

    公开(公告)号：EP1731142A1

    公开(公告)日：2006-12-13

    申请号：EP06252972.2

    申请日：2006-06-08

    申请人： Dexcel Pharma Technologies Ltd.

    发明人： Penhasi, Adel ,  Gomberg, Mila ,  Gomberg, Maxim

    IPC分类号： A61K9/28 ,  A61K9/20 ,  A61K9/48

    CPC分类号： A61K9/2886 ,  A61K9/4891

    摘要： The invention provides a delivery device for the delayed release of an active agent in the gastrointestinal tract comprising a core, comprising an active agent; a first outer coating, comprising a relatively hydrophobic substantially water insoluble polymer having substantially water insoluble hydrophilic particles embedded therein; and a first inner coating layer, comprising an agent that can cause the dissolution of at least one of the water insoluble components of the outer coating, and optionally a water soluble polymer, such that the insoluble particles in the outer coating, upon absorption of liquid, form channels leading to the inner coating layer, thus enabling the dissolution thereof, whereby the agents contained therein are released to cause the dissolution and/or degradation (destruction) of the outer coating, and the release of the pharmaceutically acceptable active agent from the core of the device.

    摘要翻译： 本发明提供了用于在胃肠道中延迟释放活性剂的递送装置，其包含核心，其包含活性剂; 第一外涂层，其包含相对疏水的基本上不溶于水的聚合物，其中嵌有基本上不溶于水的亲水性颗粒; 和第一内涂层，其包含可引起外涂层的至少一种水不溶性组分和任选的水溶性聚合物溶解的试剂，使得外涂层中的不溶性颗粒在吸收液体时 形成通向内涂层的通道，从而使其溶解，由此其中所含的试剂被释放以引起外涂层的溶解和/或降解（破坏），并且药学上可接受的活性剂从 核心的设备。

    DELAYED TOTAL RELEASE TWO PULSE GASTROINTESTINAL DRUG DELIVERY SYSTEM
    8.
    发明公开
    DELAYED TOTAL RELEASE TWO PULSE GASTROINTESTINAL DRUG DELIVERY SYSTEM 有权
    药监系统的时延，VÖLLSTANDIGEN现役消化道

    公开(公告)号：EP1189601A2

    公开(公告)日：2002-03-27

    申请号：EP00939503.9

    申请日：2000-06-02

    申请人： Dexcel Pharma Technologies Ltd.

    发明人： PENHASI, Adel ,  FLASHNER, Moshe ,  LERNER, E., Itzhak

    IPC分类号： A61K9/20 ,  A61K9/28

    CPC分类号： A61K9/286 ,  A61K9/209 ,  Y10S977/906

    摘要： A two pulse gastrointestinal delivery system is provided. The system comprises a desired agent in combination with a swellable core material, the core being surrounded by an inner coat of a water-insoluble or relatively water-insoluble coating material in which particulate water-insoluble material is embedded. The inner coat is additionally surrounded by an outer coat that contains additional amounts of the desired agent. When the delivery device enters the gastrointestinal tract, the outer coat releases the desired agent contained therein and disintegrates, exposing the inner coat. The particulate matter in the inner coat takes up liquid, thus forming channels interconnecting the drug-containing core with the outside of the delivery device. Through these channels liquid enters the core which then swells to the point at which the inner coat is broken. When the integrity of the inner coat is destroyed, the core then disintegrates, immediately releasing all or most of the drug at a specific site. By controlling parameters in the device, such as the core material, carrier material in the coating, and particulate matter, the location of release of both pulses of the drug can be carefully controlled. The invention is also directed to a method of using the device for the treatment of disease by the release of drugs in the gastrointestinal tract in a location- and time-dependent manner.