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公开(公告)号:EP0896547A1
公开(公告)日:1999-02-17
申请号:EP97922232.0
申请日:1997-04-18
申请人: Diabact AB
CPC分类号: A61K51/1206 , A61K2123/00
摘要: The present invention relates to a substantially water-free preparation for administering urea in a tablet form, a capsule form or some other solid form. The preparation dissolves very quickly in the stomach. The preparation is used to demonstrate the presence of ammonia in exhalation air, deriving from increased urease activity in the stomach in conjunction with an existing Helicobacter pylori infection.
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公开(公告)号:EP1019726A1
公开(公告)日:2000-07-19
申请号:EP96938587.1
申请日:1996-11-06
申请人: Diabact AB
发明人: HEDNER, Jan , PETTERSSON, Anders
IPC分类号: G01N33/569 , C12Q1/04 , A61K45/00
CPC分类号: A61K31/00 , G01N33/56922 , G01N2333/205 , Y10S436/90
摘要: A method for identification of an infant being particularly susceptible to sudden infant death syndrome (SIDS) comprises the determination of an Helicobacter pylori infection in the infant's mother, particularly by detection of antibodies to H. pylori of the IgG type, in a blood sample drawn from the infant's mother or by determination of carbon dioxide formed from urea in the air exhaled from the infant's mother upon oral administration of a challenge dose of urea. Also disclosed is the use of an antibiotic effective against H. pylori for the manufacture of a medicament for administration to mothers and other persons infected by H. pylori and coming into close bodily contact with infants below two years of age, and a method for prevention of SIDS by administration of that antibiotic.
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公开(公告)号:EP1228369A1
公开(公告)日:2002-08-07
申请号:EP00975087.8
申请日:2000-10-24
申请人: Diabact AB
IPC分类号: G01N33/497 , G01N33/493 , A61K51/00
CPC分类号: A61B5/412 , A61B5/0813 , A61K51/02 , A61K51/1206
摘要: A method of detecting inflammatory processes comprises (a) administering per-orally or per-rectally a composition comprising a diagnostically effective amount of L-[guanido-15N2]-arginine, L-[guanido-15N]-arginine, their mixtures and pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable carrier; (b) collecting a sample of exhaled air, saliva or urine; (c) determining 15NO in the air sample or its transformation products 15N-nitrite and/or 15N-nitrate in the saliva sample or urine. Also disclosed is a corresponding diagnostic composition for use in diagnosing inflammatory processes and a method for its manufacture.
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公开(公告)号:EP0787017A1
公开(公告)日:1997-08-06
申请号:EP95936815.0
申请日:1995-10-17
申请人: Diabact AB
CPC分类号: A61K51/1206 , A61K51/0406
摘要: The present invention relates to a preparation for administering isotope-labelled urea together with acid in tablet form, in the form of a capsule preparation, or in some other solid form. The preparation dissolves very quickly in the stomach. The preparation is used to show increased urease activity in the stomach in association with an ongoing Helicobacter pylori infection.
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公开(公告)号:EP1121938A2
公开(公告)日:2001-08-08
申请号:EP01108549.5
申请日:1996-11-06
申请人: Diabact AB
发明人: Hedner, Jan , Pettersson, Anders
CPC分类号: A61K31/00 , G01N33/56922 , G01N2333/205 , Y10S436/90
摘要: A use of an antibiotic effective against H. pylori for the manufacture of a medicament for administration to mothers or other persons infected by H. pylori but lacking symptoms and coming into close bodily contact with infants below two years of age, for prevention of SIDS.
摘要翻译: 使用对幽门螺杆菌有效的抗生素用于制造用于给予感染幽门螺杆菌的母亲或其他人但没有症状并与两岁以下的婴儿紧密身体接触的药物的药物,用于预防小儿免疫球蛋白。
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公开(公告)号:EP1115384A1
公开(公告)日:2001-07-18
申请号:EP99952868.0
申请日:1999-09-24
申请人: Diabact AB
IPC分类号: A61K9/16 , A61K31/445
CPC分类号: A61K31/445 , A61K9/006 , G06F19/00
摘要: A pharmaceutical composition for the treatment of acute pain by sublingual administration is described. The composition comprises an essentially water-free, ordered mixture of fentanyl or a pharmaceutically acceptable salt thereof in the form of microparticles which are adhered to the surface of carrier particles which are substantially larger than the particles of fentanyl, and are essentially water-soluble. In a preferred embodiment, the composition also contains a bioadhesion and/or mucoadhesion promoting agent. The invention also relates to the preparation of the composition, and to the use of the composition for the treatment of acute pain.
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7.
公开(公告)号:EP1115383A1
公开(公告)日:2001-07-18
申请号:EP99952867.2
申请日:1999-09-24
申请人: Diabact AB
IPC分类号: A61K9/16 , A61K31/445
CPC分类号: A61K9/006 , A61K9/0056 , A61K9/145 , A61K9/146 , A61K9/2018 , A61K9/2054 , A61K9/2866 , A61K31/136 , A61K31/19 , A61K31/196 , A61K31/34 , A61K31/341 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/4468 , A61K31/4745 , A61K31/485 , A61K31/4985 , A61K31/5415 , A61K31/5513 , A61K31/635 , A61K36/84 , A61K38/00 , A61K38/2242
摘要: A pharmaceutical composition for the treatment of acute disorders is described. The composition comprises an essentially water-free, ordered mixture of at least one pharmaceutically active agent in the form of microparticles which are adhered to the surfaces of carrier particles which are substantially larger than the particles of the active agent or agents, and are essentially water-soluble, in combination with the bioadhesion and/or mucoadhesion promoting agent. The invention also relates to a method for preparing the composition and to the use of the composition for the treatment of acute disorders.
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8.
公开(公告)号:EP1115384B1
公开(公告)日:2003-08-27
申请号:EP99952868.0
申请日:1999-09-24
申请人: Diabact AB
IPC分类号: A61K9/16 , A61K31/445 , A61P25/04
CPC分类号: A61K31/445 , A61K9/006 , G06F19/00
摘要: A pharmaceutical composition for the treatment of acute pain by sublingual administration is described. The composition comprises an essentially water-free, ordered mixture of fentanyl or a pharmaceutically acceptable salt thereof in the form of microparticles which are adhered to the surface of carrier particles which are substantially larger than the particles of fentanyl, and are essentially water-soluble. In a preferred embodiment, the composition also contains a bioadhesion and/or mucoadhesion promoting agent. The invention also relates to the preparation of the composition, and to the use of the composition for the treatment of acute pain.
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公开(公告)号:EP0896547B1
公开(公告)日:2002-06-26
申请号:EP97922232.0
申请日:1997-04-18
申请人: Diabact AB
IPC分类号: A61K49/00
CPC分类号: A61K51/1206 , A61K2123/00
摘要: The present invention relates to a substantially water-free preparation for administering urea in a tablet form, a capsule form or some other solid form. The preparation dissolves very quickly in the stomach. The preparation is used to demonstrate the presence of ammonia in exhalation air, deriving from increased urease activity in the stomach in conjunction with an existing Helicobacter pylori infection.
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公开(公告)号:EP1121938A3
公开(公告)日:2002-04-24
申请号:EP01108549.5
申请日:1996-11-06
申请人: Diabact AB
发明人: Hedner, Jan , Pettersson, Anders
CPC分类号: A61K31/00 , G01N33/56922 , G01N2333/205 , Y10S436/90
摘要: A use of an antibiotic effective against H. pylori for the manufacture of a medicament for administration to mothers or other persons infected by H. pylori but lacking symptoms and coming into close bodily contact with infants below two years of age, for prevention of SIDS.
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