公开(公告)号：EP0048558A3

公开(公告)日：1982-05-12

申请号：EP81304017

申请日：1981-09-02

申请人： Ed. Geistlich Söhne A.G. für Chemische Industrie

发明人： Pfirrmann, Rolf Wilhelm

IPC分类号： A61L15/03 ,  A61K09/06

CPC分类号： A61L27/52 ,  A61F2/28 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L26/0066 ,  A61L27/3608 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/406

摘要： A composition comprising a resorbable aqueous gel having dissolved or dispersed therein one or more water-soluble medicaments is of use in the treatment of wounds. Such a composition is of use in a method of healing an infection in a cavity in bone or other tissue whereby the resorbable aqueous get is placed in the cavity and allowed to remain there until resorbed, the aqueous phase of the gel containing the water soluble medicament. The medicament is preferably an antibiotic or a methylol transfer antibacterial.

公开(公告)号：EP0149540A3

公开(公告)日：1987-02-04

申请号：EP85300209

申请日：1985-01-11

申请人： Ed. Geistlich Söhne A.G. für Chemische Industrie

发明人： Spector, Myron ,  Muzzy, John D.

IPC分类号： A61B17/58

CPC分类号： A61B17/80 ,  A61L31/125 ,  A61L2430/02 ,  A61B17/58

摘要： A bone fracture fixation device which is substantially free from resorbable components and is capable in use of a gradual decrease in rigidity over the fracture healing period from a rigidity close to or in excess of that of the intact bone to a rigidity significantly below that of the intact bone.

公开(公告)号：EP0139534A3

公开(公告)日：1985-10-23

申请号：EP84307226

申请日：1984-10-19

申请人： Ed. Geistlich Söhne A.G. für Chemische Industrie

发明人： Pfirrmann, Rolf Wilhelm

IPC分类号： A61K31/54

CPC分类号： A61K31/54 ,  C07D285/18

摘要： Compounds of formula (I)
[wherein R 1 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and R 2 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or a group of formula (II)
in which R' is as defined above] and pharmaceutical compositions thereof may be administered prophylactically to humans or warm-blooded animals to combat the occurrence of osteitis or osteomyelitis, especially in patients suffering from bone injuries of traumatic origin.

公开(公告)号：EP0165074A3

公开(公告)日：1987-03-04

申请号：EP85304290

申请日：1985-06-14

申请人： Ed. Geistlich Söhne A.G. für Chemische Industrie

发明人： Lüssi, Heinz ,  Geistlich, Peter

IPC分类号： C08F289/00 ,  C08F251/00 ,  A61L15/00

CPC分类号： C08F289/00 ,  A61L15/225 ,  A61L15/60 ,  C08F251/00 ,  C08L5/12 ,  C08L33/26 ,  C08L89/00

摘要： An enhanced water-absorbency hydrophilic polymer material, suitable for use in for example would dressings, is prepared by a process in which a water-containing organic hydrogel comprising a gelable polysaccharide and/or protein or polypeptide interpersed with a polymer of a hydrophilic acrylic or methacrylic acid derivative is permeated with a base, the pH of said hydrogel being raised to at least 9 during treatment with said base.

公开(公告)号：EP0206692A3

公开(公告)日：1988-07-27

申请号：EP86304571

申请日：1986-06-13

申请人： Ed. Geistlich Söhne A.G. für Chemische Industrie

发明人： Geistlich, Peter

IPC分类号： A61L25/00 ,  A61K33/30

CPC分类号： A61K47/36 ,  A61K9/0014 ,  A61K47/32 ,  A61K47/38 ,  A61L26/0023 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/102 ,  A61L2300/214 ,  A61L2300/602

摘要： A topically administrable wound-healing composition is decribed which comprises a physiologically acceptable zinc compound and one or more topical pharmaceutical carriers. The compositions are capable of sustained release of zinc ions and thereby promote granulation and tissue regeneration at the wound site.

摘要翻译： 描述了局部施用的伤口愈合组合物，其包含生理上可接受的锌化合物和一种或多种局部药物载体。 组合物能够持续释放锌离子，从而促进伤口部位的造粒和组织再生。

公开(公告)号：EP0137743A3

公开(公告)日：1986-10-01

申请号：EP84306236

申请日：1984-09-12

申请人： Ed. Geistlich Söhne A.G. für Chemische Industrie

发明人： Geistlich, Peter

IPC分类号： A61K47/00 ,  A61L15/03 ,  A61K31/195 ,  A61K33/14

CPC分类号： A61K9/0014 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61L26/0023 ,  A61L26/0028 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/102 ,  A61L2300/214 ,  A61L2300/412 ,  C08L1/28 ,  C08L33/26

摘要： The invention provides pharmaceutical compositions in solid or semi-solid form for topical application to external wounds to enhance tissue regeneration comprising calcium and potassium ions, physiologically acceptable counter ions therefor and one or more topical pharmaceutical carriers or excipients. The compositions include in particular, semi solid gels containing amino acids and solid gels adapted to release wound-healing substances.

摘要翻译： 本发明提供了固体或半固体形式的药物组合物，用于局部施用于外部伤口以增强包含钙和钾离子的组织再生，其生理上可接受的抗衡离子和一种或多种局部药物载体或赋形剂。 组合物特别包括含有氨基酸的半固体凝胶和适于释放伤口愈合物质的固体凝胶。

公开(公告)号：EP0139535A3

公开(公告)日：1985-10-23

申请号：EP84307227

申请日：1984-10-19

申请人： Ed. Geistlich Söhne A.G. für Chemische Industrie

发明人： Pfirrmann, Rolf Wilhelm

IPC分类号： A61K31/54

CPC分类号： A61K31/54 ,  C07D285/18 ,  Y02A50/473

摘要： Compounds of formula (I)
[wherein R 1 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and R 2 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or a group of formula II
in which R 1 is as defined above] and pharmaceutical compositions thereof may be administered to humans or warm-blooded animals to combat toxic proteins or peptides, e.g. venoms, fungal toxins and bacterial exotoxins, in the bloodstream.

公开(公告)号：EP0047647A3

公开(公告)日：1982-09-15

申请号：EP81304053

申请日：1981-09-04

申请人： Ed. Geistlich Söhne A.G. für Chemische Industrie

发明人： Jackson, George Morley

IPC分类号： A61K09/06 ,  A61K09/08 ,  A61K31/19 ,  A61K31/195

CPC分类号： A61K9/0014 ,  A61K31/195 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61L26/0066 ,  A61L26/008 ,  A61L2300/21 ,  A61L2300/214 ,  A61L2300/45 ,  A61K31/19

摘要： The invention relates to pharmaceutical compositions in the form of semi-solid aqueous gels for use in wound alimentation by application to a wound during healing. The compositions contain in solution each of the essential and semi-essential amino acids and malic acid and have a pH in the range 6.5 to 8.