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1.发明公开
公开(公告)号：EP4345160A3
公开(公告)日：2024-07-03
申请号：EP23214033.5
申请日：2016-09-07
申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services , FUJIFILM Cellular Dynamics, Inc.
IPC分类号： C12N5/079
CPC分类号： C12N2501/10520130101 , C12N2501/1520130101 , C12N2501/15520130101 , C12N2501/1620130101 , C12N2501/41520130101 , C12N2506/4520130101 , C12N2533/5020130101 , C12N2533/5220130101 , C12N5/0621
摘要： Provided herein are methods of producing an RPE cell population from a starting cell suspension, such as a single cell suspension, of pluripotent stem cells (PSCs). Such a method may comprise culturing the starting single cell suspension of PSCs in differentiation media to produce human RPE cells.
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公开(公告)号：EP3119881B1
公开(公告)日：2023-03-01
申请号：EP15718000.1
申请日：2015-03-20
发明人： GEORGE, Matt , CHAVEZ, Carrie , MCMAHON, Chris , WANG, Wen, Bo , CHASE, Lucas , SWANSON, Brad
IPC分类号： C12N5/0793
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公开(公告)号：EP2582792B1
公开(公告)日：2018-10-31
申请号：EP11796584.8
申请日：2011-06-20
发明人： MEYER, Nathan , SWANSON, Brad , FIENE, Steve
CPC分类号： C12N5/0657 , C12N2500/00 , C12N2501/999
摘要： Methods and composition for maintenance of cardiomyocytes are provided. For example, in certain aspects methods including culturing the cardiomyocytes in a medium essentially free of serum or containing dialyzed serum to maintain long-term purity. In further aspects, methods for modulation of cardiomyocytes may be provided.
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公开(公告)号：EP3365429A1
公开(公告)日：2018-08-29
申请号：EP16788618.3
申请日：2016-10-19
摘要： The present disclosure provides methods for maturing hepatocytes comprising culturing with cyclic adenosine monophosphate and a Janus kinase inhibitor. There is also provided a method for screening inhibitors of hepatitis B virus infection and/or replication.
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公开(公告)号：EP4423253A1
公开(公告)日：2024-09-04
申请号：EP22814583.5
申请日：2022-10-28
发明人： RAJESH, Deepika , FATHI, Ali , LIU, Jing , BAKSHY, Kiranmayee , DICKERSON, Sarah , POON, Wayne
IPC分类号： C12N5/0793
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7.发明公开
公开(公告)号：EP4399282A2
公开(公告)日：2024-07-17
申请号：EP22783254.0
申请日：2022-09-12
发明人： RAJESH, Deepika , MUNN, Christie , BURTON, Sarah , DONEGAN, Madelyn, Elise , OSHIMA, Makiko , CARLSON, Coby , LIVINGSTON, Megan , TOMOTOSHI, Kimihiko , FATHI, Ali , LIU, Jing , POON, Wayne , HILCOVE, Simone , BAKSHY, Kiranmayee
IPC分类号： C12N5/079 , C12N5/0793
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公开(公告)号：EP2582794B2
公开(公告)日：2024-04-24
申请号：EP11796290.2
申请日：2011-06-14
IPC分类号： C12N5/0789 , C12N5/074 , C12N5/02 , C07K14/475
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公开(公告)号：EP3612557B1
公开(公告)日：2022-01-19
申请号：EP18724646.7
申请日：2018-04-18
发明人： VODYANYK, Maksym, A. , ZHANG, Xin , BRANDL, Andrew, J. , RAJESH, Deepika , SWANSON, Bradley , MUNN, Christie , BURTON, Sarah , WANG, Wen, Bo , MCLEOD, Ethan
IPC分类号： C07K14/725 , A61K38/17 , A61K35/17 , A61K35/545 , C12N5/0783 , C12N5/074 , A61P35/00 , C07K16/28
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公开(公告)号：EP2591093B1
公开(公告)日：2018-11-28
申请号：EP11804353.8
申请日：2011-07-07
发明人： YU, Junying , VODYANYK, Maksym, A.
CPC分类号： C12N15/85 , C12N5/069 , C12N5/0692 , C12N2501/40 , C12N2506/02 , C12N2506/45 , G01N33/5064 , G01N2500/10
摘要： The invention generally regards methods for providing endothelial cells and precursors of endothelial cells from a variety of cell sources, such as pluripotent stem cells. Also provided are therapeutic compositions including the provided endothelial cells, and methods of using them for the treatment of subjects.
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