公开(公告)号：EP2483393B1

公开(公告)日：2018-08-08

申请号：EP10760857.2

申请日：2010-09-22

Applicant: DePuy Synthes Products, Inc.

Inventor： COLTER, David, C. ,  BUENSUCESO, Charito ,  KAZANECKI, Christian, C. ,  GOSIEWSKA, Anna, C.

IPC: C12N5/077 ,  C12N5/0775 ,  C12N5/074

CPC classification number: C12N5/069 ,  C12N5/0668 ,  C12N5/0692 ,  C12N2509/00

Abstract: An isolated mammalian internal mammary artery-derived cell is disclosed. Furthermore, methods of isolating the mammalian internal mammary artery-derived cell are disclosed. The cell is useful in tissue engineering technologies, specifically in vascular tissue engineering.

公开(公告)号：EP2609191B1

公开(公告)日：2017-11-22

申请号：EP11820597.0

申请日：2011-08-24

Applicant: Regents Of The University Of Minnesota ,  Katholieke Universiteit Leuven

Inventor： SUBRAMANIAN, Kartik ,  HU, Wei-Shou ,  VERFAILLIE, Catherine, M. ,  PARK, Yonsil

IPC: C12N5/074 ,  C12N5/0775

CPC classification number: C12N5/0607 ,  C12N5/0606 ,  C12N5/0662 ,  C12N5/0692 ,  C12N5/0695 ,  C12N5/0696 ,  C12N2500/02 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2502/02 ,  C12N2513/00

Abstract: The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells.

公开(公告)号：EP2970914A4

公开(公告)日：2017-01-11

申请号：EP14763473

申请日：2014-03-13

Applicant: UNIV QUEENSLAND

Inventor： PATEL JATIN ,  KHOSROTEHRANI PAUL KIARASH ,  FISK NICHOLAS MAXWELL

IPC: C12N5/0789 ,  A61K45/00 ,  C12N5/073 ,  C12N5/074 ,  C12N5/0775

CPC classification number: A61K35/44 ,  A61K35/28 ,  A61K45/06 ,  A61L27/18 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/54 ,  A61L31/005 ,  A61L31/16 ,  A61L2430/34 ,  C12N5/0668 ,  C12N5/0692 ,  C12N2506/025

Abstract: Disclosed are methods for isolating endothelial progenitor cells (EPC). More particularly, the present invention discloses methods for isolating endothelial progenitor cells that exhibit self-renewal and differentiation capacity. The isolated cellular population of the present invention is useful in a wide range of clinical and research setting including inter alia, the in vitro or in vivo generation of endothelial cells and the therapeutic or prophylactic treatment of a range of conditions via the administration of these cells. Also facilitated is the isolation of endothelial progenitor cells for research purposes such as in vitro based screening systems for testing the therapeutic impact and/or toxicity of potential treatment or culture regimes to which these cells may be exposed to. The present invention also discloses methods for isolating mesenchymal stem cells, in particular mesenchymal stem cells of fetal and/or maternal origin. These cells are also useful in a range of in vitro and in vivo therapeutic, prophylactic and research applications.

公开(公告)号：EP2879684A4

公开(公告)日：2016-07-20

申请号：EP13824807

申请日：2013-07-30

Applicant: UNITED THERAPEUTICS CORP

Inventor： JEFFS ROGER ,  PETERSEN THOMAS ,  ILAGAN ROGER M ,  WADE MICHAEL

IPC: A61K31/5585

CPC classification number: A61K35/44 ,  A61K31/5585 ,  A61K35/28 ,  A61K45/06 ,  C12N5/0692 ,  C12N2501/999 ,  F04C2270/041 ,  A61K2300/00

Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.

Abstract translation: 目前的应用涉及一种治疗肺动脉高压（PAH）的方法，包括：提供分离的内皮祖细胞（EPCs）; 用前列环素处理EPCs，其中经处理的EPC通过具有增强的血管生成性质的增生型表现出来; 以及将包含经处理的EPC的组合物施用于患有PAH的受试者。

公开(公告)号：EP2970914A1

公开(公告)日：2016-01-20

申请号：EP14763473.7

申请日：2014-03-13

Applicant: The University Of Queensland

Inventor： PATEL, Jatin ,  KHOSROTEHRANI, Paul Kiarash ,  FISK, Nicholas Maxwell

IPC: C12N5/0789 ,  C12N5/0775 ,  C12N5/074 ,  C12N5/073 ,  A61K45/00

CPC classification number: A61K35/44 ,  A61K35/28 ,  A61K45/06 ,  A61L27/18 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/54 ,  A61L31/005 ,  A61L31/16 ,  A61L2430/34 ,  C12N5/0668 ,  C12N5/0692 ,  C12N2506/025

Abstract: Disclosed are methods for isolating endothelial progenitor cells (EPC). More particularly, the present invention discloses methods for isolating endothelial progenitor cells that exhibit self-renewal and differentiation capacity. The isolated cellular population of the present invention is useful in a wide range of clinical and research setting including inter alia, the in vitro or in vivo generation of endothelial cells and the therapeutic or prophylactic treatment of a range of conditions via the administration of these cells. Also facilitated is the isolation of endothelial progenitor cells for research purposes such as in vitro based screening systems for testing the therapeutic impact and/or toxicity of potential treatment or culture regimes to which these cells may be exposed to. The present invention also discloses methods for isolating mesenchymal stem cells, in particular mesenchymal stem cells of fetal and/or maternal origin. These cells are also useful in a range of in vitro and in vivo therapeutic, prophylactic and research applications.

Abstract translation: 本发明公开了用于分离的内皮祖细胞（EPC）的方法。 更具体地，用于分离内皮祖细胞本发明圆盘更少方法的确显示自我更新和分化能力。 本发明的分离的细胞群，尤其包括，在体外或体内产生内皮细胞，并通过合成的细胞的施用的范围内的条件的治疗或预防性治疗是在广泛的临床和研究设置有用 ， 所以促进是内皮祖细胞用于研究目的的隔离：诸如用于测试，以其中合成的细胞可以暴露于潜在的治疗或培养制度的治疗作用和/或毒性在体外基于筛选系统。 因此，本发明的圆盘更小的方法用于分离间充质干细胞，间质干细胞中的胎儿和/或母体来源的特殊。 这些细胞因此在一个范围内的在体外和体内的治疗性，预防性和研究应用是有用的。

公开(公告)号：EP2524031B1

公开(公告)日：2015-07-08

申请号：EP11704276.2

申请日：2011-01-11

Applicant: Centre National de la Recherche Scientifique (CNRS) ,  Ludwik Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences

Inventor： KIEDA, Claudine ,  GRILLON, Catherine ,  LAMERANT-FAYEL, Nathalie ,  PAPROCKA, Maria ,  KRAWCZENKO, Agnieszka ,  GOSZYK-DUS, Danuta

IPC: C12N5/071 ,  G01N33/50 ,  C12N5/074

CPC classification number: C12N5/0692 ,  G01N33/5064 ,  G01N33/5073

公开(公告)号：EP2683814A4

公开(公告)日：2014-09-24

申请号：EP12758340

申请日：2012-03-12

Applicant: UNIV SINGAPORE

Inventor： RAGHUNATH MICHAEL ,  BLOCKI ANNA

IPC: C12N5/0789 ,  A61K35/14 ,  C12N5/074

CPC classification number: C12N5/069 ,  A61K38/00 ,  C12N5/0692 ,  C12N2500/38 ,  C12N2502/28 ,  C12N2533/52 ,  C12N2533/70 ,  C12N2533/90

Abstract: Thus, provided herein are pericyte progenitor cells (e.g., isolated pericyte progenitor cells), methods for generating pericyte progenitors in clinically relevant numbers for various applications applying macromolecular crowding during cell culture, and methods of using the pericyte progenitor cells.

Abstract translation: 因此，本文提供的是周细胞祖细胞（例如，分离的周细胞祖细胞），用于在细胞培养期间应用大分子拥挤的各种应用的临床相关数中产生周细胞祖细胞的方法，以及使用周细胞祖细胞的方法。

公开(公告)号：EP1988847B1

公开(公告)日：2014-08-13

申请号：EP07763205.7

申请日：2007-02-08

Applicant: Northwestern University

Inventor： AMEER, Guillermo ,  YANG, Jian

IPC: A61L27/16 ,  A61L27/48 ,  A61L27/58 ,  A61L31/10 ,  A61L33/06 ,  C12N5/071 ,  A61L27/38 ,  A61L27/34

CPC classification number: A61L31/10 ,  A61L27/16 ,  A61L27/34 ,  A61L27/3804 ,  A61L27/48 ,  A61L27/507 ,  A61L27/58 ,  A61L33/068 ,  C12N5/0692 ,  C12N2533/40 ,  Y10T428/31507 ,  Y10T428/3154 ,  Y10T428/31565 ,  Y10T428/31663 ,  Y10T428/31681 ,  Y10T428/31736 ,  Y10T428/31786 ,  Y10T428/3179 ,  Y10T428/31797 ,  C08L27/18 ,  C08L67/04

公开(公告)号：EP2683814A1

公开(公告)日：2014-01-15

申请号：EP12758340.9

申请日：2012-03-12

Applicant: National University of Singapore

Inventor： RAGHUNATH, Michael ,  BLOCKI, Anna

IPC: C12N5/0789 ,  A61K35/14 ,  C12N5/074

CPC classification number: C12N5/069 ,  A61K38/00 ,  C12N5/0692 ,  C12N2500/38 ,  C12N2502/28 ,  C12N2533/52 ,  C12N2533/70 ,  C12N2533/90

Abstract: Thus, provided herein are pericyte progenitor cells (e.g., isolated pericyte progenitor cells), methods for generating pericyte progenitors in clinically relevant numbers for various applications applying macromolecular crowding during cell culture, and methods of using the pericyte progenitor cells.

Abstract translation: 因此，本文提供了周细胞祖细胞（例如，分离的周细胞祖细胞），产生周细胞祖细胞的方法，用于在细胞培养过程中应用大分子拥挤的各种应用的临床相关数量，以及使用周细胞祖细胞的方法。

公开(公告)号：EP2643028A2

公开(公告)日：2013-10-02

申请号：EP11797268.7

申请日：2011-11-28

Applicant: Crioestaminal, Saúde e Tecnologia, SA.

Inventor： DA SILVA FERREIRA, Lino ,  DOS SANTOS PEDROSO, Dora Cristina

IPC: A61L27/22 ,  A61L27/38 ,  C12N5/078

CPC classification number: A61K35/51 ,  A61K2035/124 ,  A61L26/0057 ,  A61L26/008 ,  A61L27/3834 ,  A61L27/3886 ,  A61L27/52 ,  C12N5/0647 ,  C12N5/0692 ,  C12N2501/165 ,  C12N2502/28 ,  C12N2506/11 ,  C12N2533/56

Abstract: The invention relates to a composition and method used for injuries treatment with a surprisingly therapeutic effect. This composition comprises a population of cells derived from human umbilical cord blood which expresses one of the following markers: CD34, CD45, and CD31; a population of CD34+ derived endothelial cells; and a biomimetic gel, preferably fibrin. The method for obtaining the composition comprises the derivation of a population of endothelial cells from CD34+ cells and then a co-culture of a CD34+ cells with CD34+-derived endothelial cells within a biomimetic gel.