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公开(公告)号：EP3630141A1
公开(公告)日：2020-04-08
申请号：EP18810361.8
申请日：2018-05-30
发明人： HJORTH, Mads Fiil , ASTRUP, Arne , ZOHAR, Yishai
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2.发明公开METHOD FOR PRODUCING HYDROGELS COUPLING HIGH ELASTIC MODULUS AND ABSORBANCE 审中-公开生产水凝胶偶联高弹性模量和吸收的方法
公开(公告)号：EP3250612A1
公开(公告)日：2017-12-06
申请号：EP16744185.6
申请日：2016-01-29
申请人： Gelesis LLC
发明人： SANNINO, Alessandro , DEMITRI, Christian , ZOHAR, Yishai , RON, Eyal S. , HAND, Barry J. , SAPONARO, Cosimo
IPC分类号： C08B3/00
CPC分类号： C08B15/005 , A61K9/0053 , A61K9/4866 , A61K31/738
摘要： The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.
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公开(公告)号：EP3157536A4
公开(公告)日：2018-01-24
申请号：EP15810383
申请日：2015-06-19
申请人： GELESIS LLC
发明人： HESHMATI HASSAN , RON EYAL S , SANNINO ALESSANDRO , ZOHAR YISHAI
IPC分类号： A61K31/715 , A23L29/262 , A61K9/00 , A61K47/38 , C08B3/12
CPC分类号： A61K31/738 , A61K9/0095 , A61K47/38
摘要： The present invention relates to methods of managing weight, and treating overweight or obesity and treating or preventing diabetes in a subject in need thereof. In one embodiment, the method comprises the steps of (a) orally administering to the subject from about 0.7 g to about 4 g of crosslinked carboxymethylcellulose; and (b) orally administering to the subject at least about 100 mL of water per gram of crosslinked carboxymethylcellulose. Steps (a) and (b) are conducted prior to or with at least one meal per day.
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公开(公告)号：EP2717685B1
公开(公告)日：2018-08-22
申请号：EP12796455.9
申请日：2012-06-07
申请人： Gelesis LLC
CPC分类号： C08B3/12 , C08B11/08 , C08B11/12 , C08B11/20 , C08B15/005 , C08J3/075 , C08J2301/00 , C08J2301/08 , C08J2301/26 , C08J2301/28 , C08L1/08 , C08L1/284 , C08L1/286 , Y10T428/2982
摘要： The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.
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6.发明授权METHODS AND COMPOSITIONS FOR WEIGHT MANAGEMENT AND FOR IMPROVING GLYCEMIC CONTROL 有权方法和体重管理的组合物和改善血糖控制
公开(公告)号：EP2358218B1
公开(公告)日：2017-04-12
申请号：EP09828168.6
申请日：2009-11-18
申请人： Gelesis LLC
CPC分类号： A23L2/52 , A21D2/145 , A21D2/18 , A21D2/188 , A21D13/80 , A23G9/34 , A23L2/68 , A23L7/10 , A23L7/109 , A23L7/122 , A23L7/126 , A23L29/288 , A23L33/24 , A23L33/30 , A23V2002/00 , A61K47/38 , C08B13/00 , C08B15/005 , C08J3/075 , C08J2301/02 , C08J2301/10 , C08L1/32 , A23V2200/326 , A23V2200/32 , A23V2200/332 , A23V2200/328 , A23V2250/51082 , A23V2250/032 , A23V2200/244
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公开(公告)号：EP2178922B1
公开(公告)日：2015-10-07
申请号：EP08785471.7
申请日：2008-08-08
申请人： Gelesis LLC
CPC分类号： A61K31/765 , A23L29/262 , A61K9/06 , A61K47/38 , A61L15/225 , A61L15/28 , A61L15/60 , C08B11/20 , C08B15/005 , C08J3/24 , C08J3/246 , C08J2301/28 , Y02E50/343 , Y02W30/47 , C08L1/26
摘要： The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.
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公开(公告)号：EP4429703A1
公开(公告)日：2024-09-18
申请号：EP22893702.5
申请日：2022-11-14
申请人： Gelesis, LLC.
发明人： JONES, Bryan , SANNINO, Alessandro , ZOHAR, Yishai , DEMITRI, Christian , CHIQUETTE, Elaine , RESCIGNO, Maria , SILVESTRI, Alessandra , GOMEZ-GIL, Antonio
IPC分类号： A61K47/38 , A61P1/00 , A61K31/717
CPC分类号： A61P1/00 , A61K47/38 , A61K31/717 , A61K35/741 , A61K9/06 , A61K9/0053 , A61K35/745 , A61K35/747
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公开(公告)号：EP3448365A1
公开(公告)日：2019-03-06
申请号：EP17790183.2
申请日：2017-04-24
申请人： Gelesis, LLC.
发明人： SANNINO, Alessandro , DEMITRI, Christian , ZOHAR, Yishai , RON, Eyal, S. , HAND, Barry, J. , SAPONARO, Cosimo
IPC分类号： A61K9/14 , A61K9/18 , A61K31/738 , A61K47/26 , A61K47/38 , A23L29/262 , C07H3/06
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公开(公告)号：EP3157536A1
公开(公告)日：2017-04-26
申请号：EP15810383.8
申请日：2015-06-19
申请人： Gelesis LLC
IPC分类号： A61K31/715 , C08B3/12
CPC分类号： A61K31/738 , A61K9/0095 , A61K47/38
摘要： The present invention relates to methods of managing weight, and treating overweight or obesity and treating or preventing diabetes in a subject in need thereof. In one embodiment, the method comprises the steps of (a) orally administering to the subject from about 0.7 g to about 4 g of crosslinked carboxymethylcellulose; and (b) orally administering to the subject at least about 100 mL of water per gram of crosslinked carboxymethylcellulose. Steps (a) and (b) are conducted prior to or with at least one meal per day.
摘要翻译： 本发明涉及控制体重，治疗超重或肥胖以及治疗或预防有此需要的受试者的糖尿病的方法。 在一个实施方案中，该方法包括以下步骤：（a）将约0.7g至约4g的交联羧甲基纤维素经口给予受试者; 和（b）每克交联的羧甲基纤维素口服给予受试者至少约100毫升的水。 步骤（a）和（b）在每天至少一顿饭之前进行或者至少进行一次。
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