公开(公告)号：EP3878859B1

公开(公告)日：2023-11-01

申请号：EP21161174.4

申请日：2012-06-07

发明人： JUNG, Sung Youb ,  JANG, Myung Hyun ,  SHEN, Ling Ai ,  PARK, Young Kyung ,  PARK, Young Jin ,  KWON, Se Chang

IPC分类号： C07K14/605 ,  A61K38/26 ,  A61P3/04

公开(公告)号：EP2718318B1

公开(公告)日：2018-07-25

申请号：EP12797363.4

申请日：2012-06-07

申请人： Hanmi Science Co., Ltd.

发明人： JUNG, Sung Youb ,  JANG, Myung Hyun ,  SHEN, Ling Ai ,  PARK, Young Kyung ,  PARK, Young Jin ,  KWON, Se Chang

IPC分类号： C07K14/605 ,  A61K38/26 ,  A61P3/04

CPC分类号： C07K14/605 ,  A61K38/00 ,  A61K38/177 ,  A61K38/22 ,  A61K38/26 ,  A61K45/06 ,  C07K14/575 ,  C07K14/705

摘要： The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native oxyntomodulin, and a composition for the prevention or treatment of obesity comprising the peptide as an active ingredient. Unlike native oxyntomodulin, the novel peptide of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis with reduced side-effects, and also shows excellent receptor-activating effects. Thus, it can be widely used in the treatment of obesity with safety and efficacy.

公开(公告)号：EP2568972B1

公开(公告)日：2017-08-02

申请号：EP11780838.6

申请日：2011-05-13

申请人： Hanmi Science Co., Ltd.

发明人： KIM, Yong Il ,  NA, Young Jun ,  KIM, Min Jung ,  KIM, Young-Hun ,  PARK, Jae Hyun ,  WOO, Jong Soo

IPC分类号： A61K9/24 ,  A61K9/20 ,  A61K31/415 ,  A61K31/40 ,  A61P3/06 ,  A61P3/00 ,  A61K9/16 ,  A61K45/06

CPC分类号： A61K31/40 ,  A61K9/1611 ,  A61K9/1652 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/209 ,  A61K31/415 ,  A61K45/06 ,  A61K2300/00

公开(公告)号：EP2528925B1

公开(公告)日：2017-07-05

申请号：EP11737323.3

申请日：2011-01-31

申请人： Hanmi Science Co., Ltd. ,  Korea Institute of Science and Technology ,  Catholic University Industry Academic Cooperation Foundation

发明人： SON, Jung Beom ,  JUNG, Seung Hyun ,  CHOI, Wha Il ,  JUNG, Young Hee ,  CHOI, Jae Yul ,  SONG, Ji Yeon ,  LEE, Kyu Hang ,  LEE, Jae Chul ,  KIM, Eun Young ,  AHN, Young Gil ,  KIM, Maeng Sup ,  CHOI, Hwan Geun ,  SIM, Tae Bo ,  HAM, Young Jin ,  PARK, Dong-sik ,  KIM, Hwan ,  KIM, Dong-Wook

IPC分类号： C07D495/04 ,  C07D495/14 ,  C07D409/14 ,  A61P35/00

CPC分类号： C07D495/04

公开(公告)号：EP2830649A4

公开(公告)日：2015-08-05

申请号：EP13769126

申请日：2013-03-29

申请人： HANMI SCIENCE CO LTD

发明人： LIM HYUNG KYU ,  KIM HYUN UK ,  HONG SUNG HEE ,  BAE SUNG MIN ,  KWON SE CHANG

IPC分类号： A61K38/22 ,  A61K9/08 ,  A61K38/18 ,  A61K38/27

CPC分类号： A61K47/48369 ,  A61K9/0019 ,  A61K9/08 ,  A61K38/27 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/68 ,  A61K47/6811 ,  C07K14/61 ,  C07K2319/30

摘要： The present invention relates to a liquid formulation of highly concentrated long-acting human growth hormone conjugate, comprising a pharmaceutically effective amount of the long-acting human growth hormone conjugate in which human growth hormone (hGH) is linked to an immunoglobulin Fc region, and an albumin-free stabilizer, said stabilizer comprising a buffer, a non-ionic surfactant, a sugar alcohol, and sodium chloride as an isotonic agent, and a method for preparing the same.

公开(公告)号：EP2838549A1

公开(公告)日：2015-02-25

申请号：EP13757286.3

申请日：2013-03-08

申请人： Hanmi Science Co., Ltd.

发明人： LIM, Se Young ,  PARK, Sung Hee ,  SHIN, Ryoung Ae ,  CHOI, In Young ,  KWON, Se Chang

IPC分类号： A61K38/17 ,  A61K38/16 ,  A61P1/16

CPC分类号： A61K47/48215 ,  A61K38/26 ,  A61K39/3955 ,  A61K47/60 ,  A61K47/6883 ,  A61K2039/505 ,  C07K14/605 ,  C07K16/18 ,  C07K2317/41 ,  C07K2317/75 ,  C07K2317/94

摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD), including a conjugate prepared by covalently linking an insulinotropic peptide, a non-peptidyl polymer and an immunoglobulin Fc region. The composition of the present invention maintains the in-vivo activity of the peptide at a relatively high level, and remarkably increases the blood half-life, thereby preventing triglyceride accumulation which is a typical feature of non-alcoholic fatty liver disease. Ultimately, it can be desirably employed for the prevention and treatment of non-alcoholic fatty liver disease.

公开(公告)号：EP2797621A1

公开(公告)日：2014-11-05

申请号：EP12861579.6

申请日：2012-12-28

申请人： Hanmi Science Co., Ltd.

发明人： KIM, Seung Su ,  LIM, Se Young ,  JUNG, Sung Youb ,  KWON, Se Chang

IPC分类号： A61K38/26 ,  A61K47/48 ,  A61K47/30 ,  A61P1/00

CPC分类号： A61K47/48415 ,  A61K38/26 ,  A61K47/60 ,  A61K47/68 ,  A61K47/6811

摘要： Provided are a glucagon-like peptide-2 (GLP-2) conjugate containing native GLP-2 or its derivative and an immunoglobulin Fc fragment being covalently linked via a non-peptidyl polymer, wherein the native GLP-2 or its derivative has a thiol group introduced at its C-terminal end, and one end of the non-peptidyl polymer is linked to an amino acid residue of the GLP-2 other than the N-terminal amino group thereof; a method for preparing the GLP-2 conjugate; a pharmaceutical composition comprising the same; and a method for treating or preventing intestinal disease, intestinal injury, or gastrosis by using the same. Since the GLP-2 conjugate of the present invention has a remarkably increased binding affinity to a GLP-2 receptor, it shows a prolonged in vivo half-life and an improved in vivo durability and stability.

公开(公告)号：EP2593084A4

公开(公告)日：2014-11-05

申请号：EP11807064

申请日：2011-07-14

申请人： HANMI SCIENCE CO LTD

发明人： HONG SUNG HEE ,  LEE BYUNG SUN ,  IM DAE SEONG ,  LEE JAE MIN ,  BAE SUNG MIN ,  KWON SE CHANG

IPC分类号： A61K9/08 ,  A61K38/27 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61K47/48

CPC分类号： A61K47/48415 ,  A61K9/0019 ,  A61K9/08 ,  A61K38/27 ,  A61K47/12 ,  A61K47/26 ,  A61K47/60 ,  A61K47/68 ,  C07K2319/30

摘要： Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.

公开(公告)号：EP2753348A1

公开(公告)日：2014-07-16

申请号：EP12830783.2

申请日：2012-09-05

申请人： Hanmi Science Co., Ltd. ,  Beijing Hanmi Pharmaceutical Co., Ltd.

发明人： JUNG, Sung Youb ,  WOO, Young Eun ,  LIM, Se Young ,  CHOI, In Young ,  LEE, Jae Ho ,  KWON, Se Chang ,  MOON, Sung Hwan ,  LIU, Jiawang

IPC分类号： A61K38/21 ,  A61K39/395 ,  A61K47/48 ,  A61K47/30 ,  A61P35/00

摘要： A method for preventing or treating a cancer includes administering an anti-cancer pharmaceutical composition including an interferon alpha or a polymer conjugate thereof. The pharmaceutical composition can be co-administered with anti-cancer agents. The interferon alpha conjugate shows a longer in vivo half-life and a more excellent anti-cancer activity than the conventional interferon alpha, and in particular, its co-administration with an anti-cancer agent such as gemcitabine has synergistic inhibitory effects on cancer cell growth and proliferation so as to exhibit a remarkably excellent anti-cancer activity. Further, the anti-cancer pharmaceutical composition has excellent in vivo half-life and anti-cancer activity to greatly reduce administration frequency. Co-administration of an anti-cancer agent and the interferon alpha conjugate having excellent anti-cancer activity reduces administration dose of anti-cancer agent so as to reduce side effects of anti-cancer agent and increase treatment compliance of patient.

公开(公告)号：EP2568972A4

公开(公告)日：2014-07-02

申请号：EP11780838

申请日：2011-05-13

申请人： HANMI SCIENCE CO LTD

发明人： KIM YONG IL ,  NA YOUNG JUN ,  KIM MIN JUNG ,  KIM YOUNG-HUN ,  PARK JAE HYUN ,  WOO JONG SOO

IPC分类号： A61K9/24 ,  A61K9/16 ,  A61K9/20 ,  A61K31/40 ,  A61K31/415 ,  A61K45/06 ,  A61P3/00 ,  A61P3/06

CPC分类号： A61K31/40 ,  A61K9/1611 ,  A61K9/1652 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/209 ,  A61K31/415 ,  A61K45/06 ,  A61K2300/00