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1.发明公开New process for isomerizing fused bicyclic structures and preparation of vitamin D analogs comprising the same 审中-公开异构化稠合双环结构和含有它们的制剂的维生素D类似物处理新
公开(公告)号：EP2360146A1
公开(公告)日：2011-08-24
申请号：EP11151947.6
申请日：2011-01-25
申请人： Hybrigenics S.A.
IPC分类号： C07C401/00 , C07C45/67 , C07C49/753 , C07C41/30 , C07C43/172 , C07C43/178
CPC分类号： C07C401/00 , C07B2200/07 , C07C45/67 , C07C2602/24 , C07C49/753
摘要： The present invention concerns a process of isomerizing trans fused bicyclic derivatives into cis fused bicyclic derivatives and the preparation of vitamin D or analogs thereof comprising said isomerisation step.
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2.发明公开New process for isomerizing fused bicyclic structures and preparation of vitamin D analogs comprising the same 有权异构化稠合双环结构和含有它们的制剂的维生素D类似物处理新
公开(公告)号：EP2360145A1
公开(公告)日：2011-08-24
申请号：EP10305088.6
申请日：2010-01-26
申请人： Hybrigenics S.A.
IPC分类号： C07C401/00 , C07C45/67 , C07C49/753 , C07C41/30 , C07C43/172 , C07C43/178
CPC分类号： C07C401/00 , C07B2200/07 , C07C45/67 , C07C2602/24 , C07C49/753
摘要： The present invention concerns a process of isomerizing trans fused bicyclic derivatives into cis fused bicyclic derivatives and the preparation of vitamin D or analogs thereof comprising said isomerisation step.
摘要翻译： 本发明涉及反式异构化稠合双环衍生物为顺式稠合双环衍生物和维生素D或其类似物包含所述异构化步骤制备的处理。
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3.发明公开
公开(公告)号：EP2084163A2
公开(公告)日：2009-08-05
申请号：EP07848828.5
申请日：2007-10-25
申请人： Hybrigenics S.A.
发明人： GUEDAT, Philippe , JACQ, Xavier , COLLAND, Frédéric , DAVIET, Laurent , FORMSTECHER, Etienne , RAIN, Jean-Christophe , COLOMBO, Matteo
IPC分类号： C07D487/04 , A61K31/53 , A61K31/4196 , A61K31/41 , A61P35/00 , A61P33/00 , A61P25/00
CPC分类号： C07D487/04
摘要： The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use : Formule (I) wherein R3, R4, R5, R6, Y, Het1, T, U, V, W, X, Ru, Rv and Rw are as defined in claim 1
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4.发明公开INHIBITORS OF CYSTEINE PROTEASES, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS 有权半胱氨酸蛋白酶抑制剂，其药物组合物及其治疗用途
公开(公告)号：EP1963328A2
公开(公告)日：2008-09-03
申请号：EP06831646.2
申请日：2006-12-05
申请人： Hybrigenics S.A.
发明人： GUEDAT, Philippe , BOISSY, Guillaume , BORG-CAPRA, Catherine , COLLAND, Frédéric , DAVIET, Laurent , FORMSTECHER, Etienne , JACQ, Xavier , RAIN, Jean-Christophe , DELANSORNE, Rémi , PERETTO, Ilaria , VIGNANDO, Stefano
IPC分类号： C07D487/04 , A61P37/02 , A61K31/4192
CPC分类号： C07D487/04
摘要： The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.
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5.发明授权New process for isomerizing fused bicyclic structures and preparation of vitamin D analogs comprising the same 有权异构化稠合双环结构和含有它们的制剂的维生素D类似物处理新
公开(公告)号：EP2360145B1
公开(公告)日：2012-03-21
申请号：EP10305088.6
申请日：2010-01-26
申请人： Hybrigenics S.A.
IPC分类号： C07C401/00 , C07C45/67 , C07C49/753 , C07C41/30 , C07C43/172 , C07C43/178
CPC分类号： C07C401/00 , C07B2200/07 , C07C45/67 , C07C2602/24 , C07C49/753
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6.发明公开Amidoacridine derivatives useful as selective inhibitors of ubiquitin specific protease 7 审中-公开氨基吖啶啶衍生物zur Verwendung als selektive Inhibitoren von Ubiquitin-spezifischer Protease 7
公开(公告)号：EP2357176A1
公开(公告)日：2011-08-17
申请号：EP10172844.2
申请日：2010-08-13
申请人： Hybrigenics S.A.
发明人： Lopez, Roman , Colland, Frédéric
IPC分类号： C07D219/04 , C07D219/06 , C07D401/12 , C07D401/14 , A61K31/473 , A61P35/00
CPC分类号： C07D401/12 , A61K31/435 , A61K31/496 , A61K31/55 , A61K45/06 , C07D219/04 , C07D219/06 , C07D401/14 , Y02A50/463 , Y02A50/465
摘要： The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.
摘要翻译： 本发明涉及泛素特异性蛋白酶的新选择性抑制剂的发现，其制备方法及其治疗用途。
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公开(公告)号：EP1749822B1
公开(公告)日：2008-10-15
申请号：EP05291683.0
申请日：2005-08-05
申请人： Hybrigenics S.A.
发明人： Guedat, Philippe , Boissy, Guillaume , Borg-Capra, Catherine , Colland, Frédéric , Daviet, Laurent , Formstecher, Etienne , Jacq, Xavier , Rain, Jean-Christophe , Delansorne, Rémi , Vallese, Stefania , Colombo, Matteo
IPC分类号： C07D241/38 , A61K31/495 , A61P35/00 , A61P25/28 , A61P9/00 , A61P31/00
CPC分类号： C07D241/38
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8.发明公开Tetracyclic inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications 审中-公开Tetrazyklische InhibitorenfürCysteinproteasen，pharmazeutische Zubereitungen und therapeutische Anwendungen
公开(公告)号：EP1918292A1
公开(公告)日：2008-05-07
申请号：EP06291686.1
申请日：2006-10-30
申请人： Hybrigenics S.A.
发明人： Guedat, Philippe , Jacq, Xavier , Colland, Frédéric , Daviet, Laurent , Formstecher, Etienne , Rain, Jean-Christophe , Colombo, Matteo
IPC分类号： C07D487/04 , A61K31/53 , A61K31/4196 , A61K31/41 , A61P35/00 , A61P33/00 , A61P25/00
CPC分类号： C07D487/04
摘要： The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use
wherein R3, R4, R5, R6, Y, Het1, T, U, V, W, X, Ru, Rv and Rw are as defined in claim 1摘要翻译： 本发明涉及式（I）的新化合物，其制备方法及其治疗用途，其中R3，R4，R5，R6，Y，Het1，T，U，V，W，X，Ru，Rv和Rw为 如权利要求1所述
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9.发明公开
公开(公告)号：EP1912954A2
公开(公告)日：2008-04-23
申请号：EP06808884.8
申请日：2006-07-26
申请人： Hybrigenics S.A.
发明人： GUEDAT, Philippe , BOISSY, Guillaume , BORG-CAPRA, Catherine , COLLAND, Frédéric , DAVIET, Laurent , FORMSTECHER, Etienne , JACQ, Xavier , RAIN, Jean-Christophe , DELANSORNE, Rémi , VALLESE, Stefania , COLOMBO, Matteo
IPC分类号： C07D241/38 , A61K31/495 , A61P35/00 , A61P25/28
CPC分类号： C07D241/38
摘要： The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.
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10.发明公开Substrates and methods for assaying deubiquitinating enzymes activity 审中-公开底物和Verfahren zur Untersuchung derAktivitätdeubiquitinierender Enzyme
公开(公告)号：EP1808493A2
公开(公告)日：2007-07-18
申请号：EP06292064.0
申请日：2006-12-28
申请人： Hybrigenics S.A.
CPC分类号： C12Q1/37 , C07K14/47 , C07K2319/23 , C07K2319/60 , C12N9/1088 , C12N9/93 , C12Q1/25 , G01N2500/04
摘要： The invention relates to substrates and methods suitable for assaying deubiquitinating enzyme activity, and in particular for screening inhibitors of enzymes involved in removal of mono or poly-ubiquitin chains from a target protein as well as inhibitors of ubiquitin precursors. Such inhibitors may have utility in the treatment of disease states associated with ubiquitin processing as well as proteolysis.
摘要翻译： 本发明涉及适用于测定去泛素化酶活性的底物和方法，特别是用于筛选参与从靶蛋白中去除单或多泛素链的酶的抑制剂以及泛素前体的抑制剂。 这种抑制剂可用于治疗与泛素加工相关的疾病状态以及蛋白水解。
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