公开(公告)号：EP0890432B1

公开(公告)日：2006-02-15

申请号：EP97939194.3

申请日：1997-09-05

申请人： KUREHA CHEMICAL INDUSTRY CO., LTD.

发明人： TANAKA, Hideaki Kureha Chemical Industry Co., Ltd. ,  OHBA, Hiroyuki Kureha Chemical Industry Co., Ltd. ,  SATO, Tomoaki Kureha Chemical Industry Co., Ltd. ,  HASEGAWA, Tomohisa Kureha Chemical Ind. Co., Ltd.

IPC分类号： B32B27/36 ,  C08G81/02 ,  C08J5/18 ,  B65D81/24 ,  C08L33/02 ,  C08L3/02 ,  C08L29/04 ,  C08F8/14 ,  C08F8/44

CPC分类号： B32B27/08 ,  B32B27/306 ,  B32B27/308 ,  B32B27/36 ,  B32B38/0036 ,  B32B2307/7242 ,  B32B2439/00 ,  B65D81/3415 ,  C08J5/18 ,  Y10S525/933 ,  Y10T428/1352 ,  Y10T428/1355 ,  Y10T428/31855

摘要： A container for retort packaging, comprising a laminated film having as the outermost layer a layer formed of a cross-linked structure comprising a poly(meth)acrylic acid (A) bonded to a polyalcoholic polymer (B) through an ester bond; and a resin composition characterized by having at least chemical structures (X), (Y) and (Z), a degree of esterification defined by the formula: (degree of esterification) = c/(b + c + d) of 0.01 to 0.5, and a degree of ionization defined by the formula: (degree of ionization) = d/(b + c + d) of 0.01 to 0.9 (wherein b, c, and d represent the molar fractions of the carbon-oxygen double bond of the chemical structures (X), (Y), and (Z), respectively in the resin composition). In chemical structure (X), R0 represents H or CH3; in chemical structure (Y), R0 represents H or CH3; and R represents a structure derived from a polyalcoholic polymer (B); and in chemical structure (Z), R0s, which may be the same or different, represents each H or CH3; Me represents an n-valent metal ion; and n is 1 to 3.

公开(公告)号：EP1609475A1

公开(公告)日：2005-12-28

申请号：EP04725517.9

申请日：2004-04-02

申请人： KUREHA CHEMICAL INDUSTRY CO., LTD.

发明人： YAMATO, Hideyuki,

IPC分类号： A61K33/44 ,  A61P19/08 ,  A61P13/12

CPC分类号： A61K33/44

摘要： An agent for treating or preventing low-turnover bone diseases, comprising as an active ingredient a spherical activated carbon, is disclosed. The low-turnover bone diseases include renal osteodystrophy and adynamic bone disease, caused by a low-turnover bone. The adynamic bone disease includes adynamic bone disease in conservative chronic kidney disease, and renal osteodystrophy in a patient under treatment with dialysis.

摘要翻译： 用于治疗或预防低骨周转疾病，作为活性成分的包含球形活性炭的药剂，是游离缺失盘。 低周转骨疾病包括肾性骨营养不良和低转化型骨病，由低骨周转引起。 该被动骨病包括保守的慢性肾脏病，肾性骨病，并根据与透析治疗的患者无力型骨病。

公开(公告)号：EP1568719A1

公开(公告)日：2005-08-31

申请号：EP03798407.7

申请日：2003-09-17

申请人： KUREHA CHEMICAL INDUSTRY CO., LTD.

发明人： TADA, Masahito Nishiki Plant ,  KATSURAO, Takumi Nishiki Research Laboratories ,  IKEDA, Tsukasa Nishiki Research Laboratories ,  SUZUKI, Kazuyuki Nishiki Research Laboratories

IPC分类号： C08F14/22

CPC分类号： C08F214/22 ,  C08F6/14 ,  C08F6/24 ,  C08F8/00 ,  Y10S526/923 ,  Y10T428/31544 ,  Y10T428/31855 ,  C08L27/16 ,  C08F14/18

摘要： The present invention provides a polyvinylidene fluoride copolymer capable of forming a uniform film, a solution of the copolymer and a thin film comprising the polyvinylidene fluoride copolymer. The polyvinylidene fluoride copolymer of the present invention is characterized in that the ratio of the scattered-light intensity (I) for a 15% solution of the polyvinylidene fluoride copolymer in dimethylformamide solvent to the scattered-light intensity (I 0 ) for dimethylformamide, (I/I 0 ), is 10 or lower. The polyvinylidene fluoride copolymer solution comprises the polyvinylidene fluoride copolymer and an organic solvent capable of dissolving the copolymer.

摘要翻译： 本发明提供了能够形成均匀膜的聚偏二氟乙烯共聚物，该共聚物的溶液和包含该聚偏二氟乙烯共聚物的薄膜。 本发明的聚偏1,1-二氟乙烯共聚物的特征在于，聚偏二氟乙烯共聚物的15％溶液在二甲基甲酰胺溶剂中的散射光强度（I）与二甲基甲酰胺的散射光强度（I 0）之比（I / I0）是10或更低。 聚偏二氟乙烯共聚物溶液包含聚偏二氟乙烯共聚物和能够溶解该共聚物的有机溶剂。

公开(公告)号：EP1539860A1

公开(公告)日：2005-06-15

申请号：EP03765282.3

申请日：2003-07-11

申请人： Kureha Chemical Industry Co., Ltd.

发明人： MATSUZAKI, Mitsuhiroc/o KUREHA CHEM. IND. CO.,LTD ,  KAGOSHIMA, Masaruc/o KUREHA CHEM. IND. CO.,LTD

IPC分类号： C08G75/02

CPC分类号： C08G75/0254 ,  C08G75/0213 ,  C08G75/0281

摘要： A process for producing polyarylene sulfide includes: steps of reacting an aromatic dihalide compound and an alkaline metal compound in a polar organic solvent for polymerization under heating and cooling a system including the reaction mixture to recover particulate polyarylene sulfide (PAS). The system after the reaction is gradually cooled at an average cooling speed of 0.2 to 1.0 deg.C/min. selectively in a temperature range of from 1 deg.C below to 1 deg.C above a maximum system-viscosity temperature. As a result, the process can be operated at a relatively short polymerization cycle and yet provides the product PAS particles with a high and stable bulk density as to exhibit good processability in the transportation and storage, and excellent transportability in a hopper or a screw of an extruder or a molding machine.

公开(公告)号：EP1452555A1

公开(公告)日：2004-09-01

申请号：EP02785981.8

申请日：2002-11-29

申请人： Kureha Chemical Industry Co., Ltd.

发明人： MIYAHARA, Michihisa ,  SAITOU, Norio ,  MATSUZAKI, Mitsuhiro

IPC分类号： C08G75/02

CPC分类号： C08G75/0281 ,  C08G75/0213 ,  C08G75/0254

摘要： A polymerizate slurry obtained through a reaction of an alkali sulfide source and an aromatic dihalide compound in an organic polar solvent and comprising polyarylene sulfide particles, a by-produced alkali metal salt and the polar organic solvent, is continuously contacted countercurrently with a washing liquid, thereby continuously and efficiently recovering washed polyarylene sulfide particles. Furthermore, the by-produced alkali metal salt is removed, and the polar organic solvent is recovered, efficiently.

摘要翻译： 通过碱金属硫化物源和芳族二卤化物在有机极性溶剂中反应并且包含聚芳硫醚颗粒，副产物碱金属盐和极性有机溶剂的反应获得的聚合物浆料与洗涤液体逆流地连续接触， 从而连续有效地回收洗涤的聚芳硫醚颗粒。 此外，除去副产的碱金属盐，有效地回收极性有机溶剂。

公开(公告)号：EP1416015A1

公开(公告)日：2004-05-06

申请号：EP03256750.5

申请日：2003-10-27

申请人： Kureha Chemical Industry Co., Ltd.

发明人： Nishihata, Naomitsu, c/o Nishi Research Lab ,  Tada, Masahito, c/o Nishiki Plant

IPC分类号： C08L73/00 ,  C08L81/02

CPC分类号： C08L71/00 ,  C08G2650/40 ,  C08L79/085 ,  C08L81/02 ,  C08L2666/20 ,  C08L2666/14 ,  C08L81/00 ,  C08L2666/22

摘要： A resin composition comprises a resin component containing 40 to 99% by mass of a poly(aryl ketone) and 1 to 60% by mass of a poly(arylene sulfide), and 0.1 to 5 parts by mass, per 100 parts by mass of the resin component, of at least one thermosetting imide resin selected from the group consisting of a polyfunctional unsaturated imide compound and its thermoset product. The resin composition is improved in terms of compatibility, moldability or formability, melt flowability, mechanical properties, etc. while maintaining high levels of various properties such as heat resistance, flame retardancy, chemical resistance and dimensional stability.

摘要翻译： 树脂组合物含有相对于100质量份的聚芳基酮为40〜99质量％，聚（亚芳基硫醚）为1〜60质量％的树脂成分和0.1〜5质量份 该树脂组分选自至少一种选自多官能不饱和酰亚胺化合物及其热固产品的热固性酰亚胺树脂。 该树脂组合物在相容性，成型性或成型性，熔体流动性，机械性能等方面得到改进，同时保持高水平的各种性能如耐热性，阻燃性，耐化学性和尺寸稳定性。

公开(公告)号：EP1406945A1

公开(公告)日：2004-04-14

申请号：EP02745857.9

申请日：2002-07-05

申请人： Kureha Chemical Industry Co., Ltd.

发明人： YAMANE, K.,Kureha Chemical Industry Co. Ltd. ,  KAWAKAMI, Y.,Kureha Chemical Industry Co. Ltd. ,  SATO, H.,Kureha Chemical Industry Co. Ltd. ,  HOSHI, T.,Kureha Chemical Industry Co. Ltd.

IPC分类号： C08G63/78 ,  C08G63/08

CPC分类号： B01J19/24 ,  B01J19/02 ,  B01J19/2415 ,  B01J2219/0236 ,  B01J2219/1943 ,  B01J2219/1946 ,  C08G63/08 ,  C08G63/78 ,  C08G63/785 ,  C08G63/89

摘要： The invention provides a polyester production process by bulk polymerization in a reactor, wherein the volume of the resulting polyester is shrunk for a release from the inner surface of the reactor, so that the polyester can be recovered in the form of a bulky mass. The invention also provides a reactor for bulk polymerization for polyester, which comprises an inner surface that enabling the resulting polyester to be released therefrom upon its volume shrinkage.

公开(公告)号：EP1389460A1

公开(公告)日：2004-02-18

申请号：EP02771732.1

申请日：2002-05-20

申请人： Kureha Chemical Industry Co., Ltd.

发明人： YANAKA, Mikiro ,  YAMAZAKI, Toru ,  BANNAI, Kenji ,  HIROSE, Kunitaka

IPC分类号： A61K31/40 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/506 ,  A61P29/00 ,  A61P35/04 ,  A61P43/00 ,  C07D207/337 ,  C07D213/36 ,  C07D215/40 ,  C07D233/64 ,  C07D233/88 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14

CPC分类号： C07D233/64 ,  A61K31/40 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/506 ,  C07D207/14 ,  C07D213/38 ,  C07D215/40 ,  C07D235/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14

摘要： To provide novel nitrogen-containing compounds having antagonism to CXCR4 and remedies for disease, such as rheumatism, cancer metastasis, etc., based on the CXCR4 antagonism.
Nitrogen-containing compounds represented by the following general formula and CXCR4 antagonists containing these compounds as an active ingredient can be provided.
The above compounds are typified by nitrogen-containing compounds represented by the following general formula (I)
wherein A 1 and A 2 represent each a guanidino group or a group represented by the following general formula (ia)
(wherein A 3 represents a monocyclic or polycyclic heterocyclic aromatic ring group having 1 or 2 hetero atoms; B 1 represents a single bond or alkylene group; and R 1 represents hydrogen or alkyl group; W represents alkylene group having 2 to 3 carbon atoms, cyclic alkylene group having 5 to 10 carbon atoms, aromatic ring having 6 to 10 carbon atoms or heterocyclic aromatic ring having 5 to 10 carbon atoms; y is - (C=O) -; x is -C (=O) -NH-; n 1 is an integer of 1 or 2; n 2 is an integer of 2 or 3; and D is selected from among various substituents:

摘要翻译： 基于CXCR4拮抗作用，提供对CXCR4具有拮抗作用的新型含氮化合物和风湿病，癌症转移等疾病的治疗方法。 可以提供由以下通式表示的含氮化合物和含有这些化合物作为活性成分的CXCR4拮抗剂。 上述化合物以下述通式（I）表示的含氮化合物为代表，其中A 1和A 2分别表示胍基或下述通式（ia）表示的基团。 CHEM>（其中A 3表示具有1或2个杂原子的单环或多环杂环芳族环基团; B 1表示单键或亚烷基; R 1表示氢或烷基; W表示亚烷基 具有2至3个碳原子的基团，具有5至10个碳原子的环状亚烷基，具有6至10个碳原子的芳族环或具有5至10个碳原子的杂环芳族环; y是 - （C = O） - ; x是 - C（= O）-NH-; n 1是1或2的整数; n 2是2或3的整数; D选自各种取代基：

公开(公告)号：EP1377566A1

公开(公告)日：2004-01-07

申请号：EP02718519.8

申请日：2002-04-10

申请人： Kureha Chemical Industry Co., Ltd.

发明人： YAMANE, Kazuyuki,c/o Kureha Chemical Ind. Co. Ltd ,  KAWAKAMI, Yukichika,c/o Kureha Chem. Ind. Co. Ltd

IPC分类号： C07D319/12

CPC分类号： C07D319/12

摘要： The invention relates to a glycolide production process wherein a depolymerization reaction system comprising a glycolic acid oligomer or a glycolic acid oligomer and a polar organic solvent is heated to depolymerize the glycolic acid oligomer into glycolide, the resulting glycolide or the glycolide and polar organic solvent are distilled out of the depolymerization reaction system, and the glycolide is recovered from distillates obtained by distillation. The glycolic acid oligomer or the glycolic acid oligomer and polar organic solvent are continuously or intermittently charged into the depolymerization reaction system, thereby carrying out depolymerization reactions continuously or repeatedly. During the depolymerization reactions, a compound having an alcoholic hydroxyl group is permitted to exist at a specific quantitative ratio in the depolymerization reaction system. The invention is also concerned with a glycolic acid oligomer for the production of glycolide, which is obtained by condensation of glycolic acid in the presence of the compound having an alcoholic hydroxyl group.

公开(公告)号：EP1357118A1

公开(公告)日：2003-10-29

申请号：EP01272547.9

申请日：2001-12-28

申请人： Kureha Chemical Industry Co., Ltd.

发明人： NIIMURA, Koichi ,  KATOHNO, Masataka ,  SAGAWA, Kazuhiko

IPC分类号： C07D311/16 ,  C07C45/45 ,  C07C47/575 ,  C07C43/23 ,  A01N43/16 ,  A01N35/04 ,  A01N37/02 ,  A01N43/30

CPC分类号： C07D493/04 ,  A01N31/16 ,  A01N35/04 ,  A01N37/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/90 ,  C07C43/23 ,  C07C45/00 ,  C07C45/515 ,  C07C45/71 ,  C07C46/06 ,  C07C46/08 ,  C07C47/565 ,  C07C47/575 ,  C07C69/017 ,  C07D311/16 ,  C07D317/46 ,  C07C50/28

摘要： An esculetin compound, an intermediate thereof, a process for manufacturing an esculetin compound, and an antifungal composition for agriculture and horticulture and an herbicide comprising an esculetin compound or an intermediate thereof are provided. The process for manufacturing an esculetin compound is a low-cost, high-yield, and industrially practicable process, and comprises the following step.
A process for manufacturing an esculetin compound of the formula (2):
characterized by cyclizing a trihydroxybenzaldehyde compound of the formula (1):
in an aprotic polar solvent in the presence of a weak base, with acetic anhydride or the like.

摘要翻译： 在在它们的中间化合物七叶亭，用于制造七叶亭化合物的方法，以及农业和园艺杀真菌组合物和除草包含七叶亭化合物或在它们中间设置。 制造七叶亭化合物的方法，是一种低成本，高产量，和工业可行的方法，并且包括以下步骤。 一种制造七叶亭式（2）的化合物的方法：通过环化式三羟基苯的化合物，其特征（1）：中在弱碱的存在下的非质子极性溶剂中， 用乙酸酐或类似物。