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1.发明公开
公开(公告)号：EP2396024A1
公开(公告)日：2011-12-21
申请号：EP10741487.2
申请日：2010-02-11
IPC分类号： A61K38/17 , A61P35/00 , G01N33/574
CPC分类号： A61K38/1709 , A61K45/06 , G01N2333/91215
摘要： The present invention relates to the use of an antisecretory factor (AF) protein, peptide, derivative, homologue, and/or fragment thereof, having equivalent functional activity, and/or a pharmaceutically active salt thereof, for optimizing delivery and cellular uptake of a pharmaceutical substance and/or formulation, or a gene delivery. Typically, said pharmaceutical substance and/or formulation comprises an anticancer drug, radiation therapy, an antibiotic substance, an antiviral substance or a drug targeting posttraumatic injury, neurodegeneration, a parasite, or an inflammatory condition.
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公开(公告)号：EP3149193A1
公开(公告)日：2017-04-05
申请号：EP15738844.8
申请日：2015-05-28
发明人： LANGE, Stefan , LÖNNROTH, Ivar
IPC分类号： C12Q1/37 , C07K16/00 , G01N33/564
CPC分类号： G01N33/564 , C07K16/00 , C07K16/18 , C12Q1/37 , G01N2333/4716 , G01N2800/7095
摘要： The disclosed assay can be used for detecting levels of circulating 26S proteasome bound to complement factor 3 or 4 in blood plasma or other body fluids, such as for monitoring levels of inflammation and virus infection in the body of a mammalian, including complement system down regulation in the body of a mammalian as well as for verifying compliance of processed cereals (SPC) and/or functional food with high levels of natural antisecretory protein (NASP).
摘要翻译： 本发明涉及一种用于确定样品中蛋白酶体补体复合物形成的存在或不存在和/或浓度的免疫测定试剂盒，例如在使用第一抗体和第二抗体的体液中，其中第一抗体是固定的 在载体上，第二抗体用标记物质修饰，第一抗体和第二抗体选自对蛋白酶体蛋白如AF1或完整蛋白酶体特异的抗体，以及补体因子C3特异的抗体，例如 作为C3，C3c，C3b，iC3b或对补体因子C4特异性的抗体，如C4，C4b，iC4b或C4c。所公开的测定法可用于检测血浆中与补体因子3或4结合的循环26S蛋白酶体的水平 或其他体液，例如用于监测哺乳动物体内炎症和病毒感染的水平，包括哺乳动物身体中的补体系统下调 用于验证加工谷物（SPC）和/或具有高水平天然抗分泌蛋白（NASP）的功能食品的顺应性。
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3.发明授权USE OF ANTISECRETORY FACTOR FOR TREATING INTRAOCULAR HYPERTENSION 有权VERWENDUNG DES ANTISEKISCHISCHEN FAKTORS ZUR BEHANDLUNG VONERHÖHTEMAUGENINNENDRUCK
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公开(公告)号：EP2037950B1
公开(公告)日：2014-04-23
申请号：EP07748080.4
申请日：2007-04-27
发明人： HANSSON, Hans-Arne
CPC分类号： A61K38/1709 , A61K38/08
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公开(公告)号：EP2468292B1
公开(公告)日：2019-12-18
申请号：EP12157100.4
申请日：2007-04-27
摘要： The present invention relates to the use of antisecretory factors, such as antisecretory proteins, homologues, derivatives and/or fragments thereof having antisecretory activity, for the manufacture of a pharmaceutical composition for use in the treatment and/or prevention of intraocular hypertension. The invention thus relates to the use of pharmaceutical compositions comprising antisecretory factors in the treatment and/or prevention of intraocular hypertension, which is preferably characterized by hampered outflow of body fluid resulting in elevated pressure in the eye. The invention provides for a novel approach for treating and/or preventing such a condition turning the intraocular pressure to an acceptable level, optionally 21 mm Hg, or less.
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公开(公告)号：EP2934564B1
公开(公告)日：2018-05-23
申请号：EP13821470.5
申请日：2013-12-20
发明人： HANSSON, Hans-Arne
摘要： The present invention relates to the use of an antisecretory factor (AF) protein, peptide, derivative, homologue, and/or fragment thereof, having equivalent functional activity, and/or a pharmaceutically active salt thereof, for treating glioblastoma. In one embodiment, AF proteins are used for optimizing delivery and cellular uptake of a pharmaceutical substance and/or formulation, or a gene delivery. Typically, said pharmaceutical substance and/or formulation comprises an anticancer drug, radiation therapy, an antibiotic substance, an immunoactive compound or a drug targeting posttraumatic injury, neurodegeneration, or an inflammatory condition.
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公开(公告)号：EP3319618A1
公开(公告)日：2018-05-16
申请号：EP16729926.2
申请日：2016-06-20
发明人： LANGE, Stefan
CPC分类号： A61K35/57 , A23K10/30 , A23K20/10 , A23K20/142 , A23K20/163 , A23K50/75 , A23L15/00 , A23L15/20
摘要： The present invention relates to a process for producing an egg yolk with a very high content of antisecretory factor (AF) proteins, in particular with a very high content of AF protein fragment consisting essentially of the amino acid sequence as shown in SEQ.ID.NO.1 (AF-16) and/or in SEQ.ID.NO.2 (AF-8), said process comprising for at least 4weeks feeding a poultry, such as a hen, an AF-16 inducing pelleted feed for poultry comprising at least 0.14% free tryptophan, such as 1-2 g tryptophan/kg feed,and thereafter harvesting egg from said poultry, separating egg yolk from egg white, and alternatively spray-drying, grinding, leaching, extracting, evaporating, membrane filtrating, and/or or freeze-drying said egg yolk. The present invention further relates to said egg yolk with a very high content of antisecretory factor (AF) proteins, produced according to the herein described process, and to their use for the preparation of functional food products and pharmaceutical products for the treatment and prophylaxis of abnormal physiological conditions caused e.g. by exceptionally high levels of body fluid discharge. The invention also relates to food products and pharmaceutical products so prepared.
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公开(公告)号：EP2363140A1
公开(公告)日：2011-09-07
申请号：EP10188590.3
申请日：2007-04-27
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of an antisecretory factor (AF) protein, a homologue and/or a fragment thereof having antisecretory activity, and/or a pharmaceutically active salt thereof, for use in the treatment and/or prevention of a compartment syndrome associated with the presence of a benign and/or a malign tumour in a body. In one embodiment, said compartment syndrome is caused by a medical treatment of said tumour, such as treatment with X-ray, high energetic radiation, local cooling, local heating, light therapy and/or anti-tumour drugs.
摘要翻译： 本发明涉及用于治疗和/或预防隔室综合征的抗分泌因子（AF）蛋白，其具有抗分泌活性的同源物和/或其片段，和/或其药物活性盐 与身体中良性和/或恶性肿瘤的存在相关。 在一个实施方案中，所述隔室综合征是由所述肿瘤的治疗引起的，例如用X射线治疗，高能辐射，局部冷却，局部加热，光疗法和/或抗肿瘤药物。
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10.发明授权ANTISECRETORY PROTEIN FOR USE IN THE TREATMENT OF COMPARTMENT SYNDROME 有权抗分泌蛋白FOR USE IN室综合征的BEHANDUNG
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