公开(公告)号：EP3404038A1

公开(公告)日：2018-11-21

申请号：EP18173066.4

申请日：2018-05-18

申请人： SYSMEX CORPORATION

发明人： Yokose, Noriko ,  Suganuma, Masatoshi ,  Noda, Kenta ,  Nishiyama, Naoki

IPC分类号： C07K14/00 ,  C12Q1/48

CPC分类号： C12Q1/485 ,  C07K2/00 ,  C07K14/00 ,  C12Y207/11022 ,  G01N33/5011 ,  G01N33/573 ,  G01N33/68 ,  G01N2333/91215 ,  G01N2333/916 ,  G01N2500/04

摘要： Disclosed is a cyclin-dependent kinase substrate including a polypeptide that contains an amino acid sequence represented by formula (1): R 1 -P (wherein R 1 represents a serine residue or a threonine residue, P represents a proline residue, "-" represents a single bond, and the left side represents the N-terminal side), and satisfies the following (al) and/or (bl): (al) the second amino acid residue counting from the proline residue toward the N-terminal side in the formula (1) is an aromatic amino acid residue, and/or (bl) at least two amino acid residues from the proline residue toward the C-terminal side in the formula (1) are acidic amino acid residues.

公开(公告)号：EP3386529A2

公开(公告)日：2018-10-17

申请号：EP16831815.2

申请日：2016-12-12

申请人： Ruprecht-Karls-Universität Heidelberg

发明人： GDYNIA, Georg ,  ROTH, Wilfried

IPC分类号： A61K38/17 ,  A61K45/06 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/7088 ,  A61P35/00

CPC分类号： C07K14/52 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/7088 ,  A61K35/00 ,  A61K38/1709 ,  A61K45/06 ,  G01N2333/91215 ,  G01N2500/10 ,  G01N2800/52 ,  A61K2300/00

摘要： The present invention relates to a combined preparation comprising (i) a modulator of pyruvate kinase M2 (PKM2) activity, and (ii) an agent providing high mobility group box 1 (HMGB1) polypeptide or a derivative thereof. The present invention also relates to the aforesaid combined preparation for use as a medicament and for use in the treatment of inappropriate cellular proliferation, preferably in the treatment of cancer. Moreover, the present invention relates to a method for determining whether a subject suffering from inappropriate cellular proliferation is amenable to a treatment comprising administration of a modulator of PKM2 activity as the only PKM2 inhibitor and to treatment methods related thereto.

公开(公告)号：EP3373010A1

公开(公告)日：2018-09-12

申请号：EP18168596.7

申请日：2014-05-21

申请人： Pierian Holdings, Inc.

发明人： KIM, Phillip ,  JAIN, Anjali ,  SINGH, Sharat

IPC分类号： G01N33/574

CPC分类号： G01N33/57419 ,  A61K39/00 ,  A61K2039/505 ,  G01N33/57492 ,  G01N2333/70596 ,  G01N2333/912 ,  G01N2333/91205 ,  G01N2333/91215 ,  G01N2440/14 ,  G01N2800/52 ,  G01N2800/54

摘要： The present invention provides assays and methods for predicting the survival of a subject having colorectal cancer (CRC), thereby determining whether the subject will have a good prognosis or poor prognosis. The present invention also provides assays and methods for predicting therapeutic efficacy and/or response to anti-cancer therapeutics in a subject having CRC, thereby selecting a therapeutic regimen to which the subject is likely to be responsive.

公开(公告)号：EP3363911A1

公开(公告)日：2018-08-22

申请号：EP16855530.8

申请日：2016-10-14

申请人： Nitto Boseki Co., Ltd

发明人： WAKABAYASHI, Masayuki ,  SATO, Natsuki ,  ISHIHARA, Hideki

IPC分类号： C12Q1/04 ,  C12Q1/48 ,  G01N33/53 ,  C12N5/09

CPC分类号： C12Q1/32 ,  A61K31/366 ,  A61K31/519 ,  A61P35/00 ,  C12Q1/04 ,  C12Q1/48 ,  G01N33/53 ,  G01N33/574 ,  G01N2333/91205 ,  G01N2333/91215

摘要： The present invention addresses the problem of providing a novel method for classifying cancer cells by an analysis method in which measurement of the activity of two types of protein kinase is used. Cancer cells are newly classified and drug sensitivity is predicted on the basis of the ratio of the activity of two types of protein kinase derived from the same sample.

公开(公告)号：EP2509595B1

公开(公告)日：2018-04-11

申请号：EP10788125.2

申请日：2010-12-10

申请人： Respivert Limited

发明人： CHARRON, Catherine, Elisabeth ,  FENTON, Robert ,  CROWE, Scott ,  ITO, Kazuhiro ,  STRONG, Peter ,  RAPEPORT, Garth ,  RAY, Keith

IPC分类号： A61K31/4155 ,  A61K45/06 ,  G01N33/50 ,  A61P31/16 ,  A61K31/5377 ,  C12N15/113 ,  A61K31/496 ,  A61K31/4439 ,  G01N33/569 ,  A61K31/506

CPC分类号： A61K31/5377 ,  A61K31/4155 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  A61K45/06 ,  C12N15/1137 ,  C12N2310/141 ,  G01N33/5023 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2333/91205 ,  G01N2333/91215 ,  G01N2500/04 ,  G01N2500/10 ,  A61K2300/00

摘要： The present invention relates inter alia to the treatment or prevention of influenza virus infection (including subtypes influenza A virus, influenza B virus, avian strain H5N1, A/H1N1, H3N2 and/or pandemic influenza) using compounds which inhibit the activity of p59-HCK and to a method of screening for a candidate drug substance intended to prevent or treat influenza virus infection in a subject, said method comprising identifying a test substance capable of inhibiting p59-HCK activity.

公开(公告)号：EP2732291B1

公开(公告)日：2017-11-29

申请号：EP12811372.7

申请日：2012-07-11

申请人： Indi Molecular, Inc. ,  California Institute of Technology

发明人： HEATH, James ,  NAG, Arundhati ,  DAS, Samir ,  DEYLE, Kaycie ,  MILLWARD, Steven, Wesley ,  KEARNEY, Paul

IPC分类号： C07K7/02 ,  C07K14/00 ,  G01N33/573 ,  G01N33/574 ,  C12Q1/48 ,  C12Q1/68 ,  A61K38/08 ,  A61K49/00 ,  C12N15/10 ,  A61K51/08

CPC分类号： C07K7/02 ,  A61K38/00 ,  A61K38/08 ,  A61K49/0043 ,  A61K49/0056 ,  A61K51/08 ,  C07K14/001 ,  C12N15/1058 ,  C12Q1/485 ,  C12Q1/6804 ,  G01N33/573 ,  G01N33/57449 ,  G01N33/5748 ,  G01N33/57496 ,  G01N2333/91205 ,  G01N2333/91215

公开(公告)号：EP3017306B1

公开(公告)日：2017-11-15

申请号：EP14736735.3

申请日：2014-07-02

申请人： Universität Heidelberg

发明人： ROTH, Wilfried ,  GDYNIA, Georg ,  SAUER, Sven

IPC分类号： G01N33/574

CPC分类号： G01N33/573 ,  G01N33/57484 ,  G01N2333/90 ,  G01N2333/90206 ,  G01N2333/90216 ,  G01N2333/904 ,  G01N2333/91215 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/7028 ,  G01N2800/7066

公开(公告)号：EP3012327A4

公开(公告)日：2017-03-22

申请号：EP14813575

申请日：2014-06-19

申请人： TAIHO PHARMACEUTICAL CO LTD

发明人： ABE TETSUYA ,  ITADANI HIRAKU

IPC分类号： C12Q1/68 ,  A61K31/366 ,  A61K31/4155 ,  A61K31/436 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5365 ,  A61K31/5377 ,  A61K31/7064 ,  A61K45/00 ,  A61P35/00 ,  C12N15/09 ,  G01N33/574 ,  G01N33/68

CPC分类号： C12Q1/6886 ,  A61K31/366 ,  A61K31/4155 ,  A61K31/436 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5365 ,  A61K31/5377 ,  A61K31/7064 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57484 ,  G01N33/57496 ,  G01N2333/4703 ,  G01N2333/91215 ,  G01N2800/52

公开(公告)号：EP3011332A1

公开(公告)日：2016-04-27

申请号：EP14814488.4

申请日：2014-06-17

申请人： CHU Sainte-Justine

发明人： MOREAU, Alain ,  AKOUME NDONG, Marie-Yvonne ,  ELBAKRY, Mohamed

IPC分类号： G01N33/48 ,  A61K31/135 ,  A61K31/519 ,  A61K31/713

CPC分类号： G01N33/573 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q1/42 ,  C12Q1/485 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Y207/01068 ,  C12Y301/03048 ,  G01N33/5047 ,  G01N33/5091 ,  G01N33/6893 ,  G01N2333/912 ,  G01N2333/91215 ,  G01N2333/916 ,  G01N2800/10 ,  G01N2800/50 ,  G01N2800/56

摘要： Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1γ tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1γ expression and/or activity.

摘要翻译： 分层患有或具有发展脊柱侧凸（AIS）为诊断或临床上都提供了有用的子类风险的受试者的方法。 分层是基于受试者的PTPμ表达和/或活性和/或表达PIPK1γ和/或活性。 因此，提供了预测，因此开发基于主题的PTPμ表达和/或活动和/或PIPK1γ表达和/或活性的脊柱侧弯的风险的方法; 在有需要的受试者，其包括施用至所述受试者的细胞以有效量酪氨酸磷酸化PIPK1γ的抑制剂的细胞增加GiPCR信令和方法; 到酪氨酸的去磷酸化的PIPK1Y活化剂; 和/或在PIPK1γ表达和/或活性的抑制剂。

公开(公告)号：EP2938613A1

公开(公告)日：2015-11-04

申请号：EP13814999.2

申请日：2013-12-30

申请人： OriBase Pharma

发明人： CHEVE, Gwénaël ,  DAYDE-CAZALS, Bénédicte ,  FAUVEL, Bénédicte ,  BORIES, Cédric ,  YASRI, Abdelaziz

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61P35/02 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/4375 ,  C12Q1/485 ,  G01N33/57484 ,  G01N2333/91215 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2500/20 ,  G01N2800/52

摘要： The present invention relates to compounds of the following formula (I) and/or the pharmaceutically acceptable addition salts, solvates, enantiomers, diastereoisomers thereof, as well as mixtures thereof. The subject matter of the present invention thus also includes the preparation of compounds of formula (I), their uses, in particular in the inhibition of protein kinases which are implicated for example in numerous diseases such as cancers or immune system disorders.