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公开(公告)号：EP3022200B1
公开(公告)日：2017-03-01
申请号：EP14759317.2
申请日：2014-07-17
发明人： BURROWS, Jeremy , WYVRATT, Matthew , VAIDYA, Akhil , KORTAGERE, Sandhya , FAN, Erkang , CHATTERJEE, Arnab Kumar , NAGLE, Advait Suresh , KATO, Tomoyo
IPC分类号： C07D403/12 , C07D231/40 , A61K31/415 , A61K31/4184 , A61P33/06
CPC分类号： C07D231/40 , A61K31/415 , A61K31/4184 , A61K45/06 , C07D403/12
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公开(公告)号：EP3118198A1
公开(公告)日：2017-01-18
申请号：EP15176514.6
申请日：2015-07-13
发明人： WATERSON, David , WITTY, Michael John , CHIBALE, Kelly , STREET, Leslie , GONZALEZ CABRERA, Diego , PAQUET, Tanya
IPC分类号： C07D401/04 , A61K31/4965 , A61K31/497 , C07D241/20 , A61P33/06
CPC分类号： C07D241/20 , A61K31/4965 , A61K31/497 , A61K45/06 , A61P33/06 , C07D401/04 , Y02A50/411 , A61K2300/00
摘要： The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.
摘要翻译： 本发明涉及氨基吡嗪衍生物在制备用于预防或治疗疟疾的药物中的用途。 具体地，本发明涉及可用于制备用于抑制疟疾寄生虫增殖的药物制剂的氨基吡嗪衍生物。
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公开(公告)号：EP2203457B1
公开(公告)日：2014-03-05
申请号：EP08845311.3
申请日：2008-10-29
发明人： VENNERSTROM, Jonathan, L. , DONG, Yuxiang , CHARMAN, Susan, A. , WITTLIN, Sergio , CHOLLET, Jacques , CREEK, Darren, J. , WANG, Xiaofang , SRIRAGHAVAN, Kamaraj , ZHOU, Lin , MATILE, Hugues , CHARMAN, William, N.
IPC分类号： C07D493/10 , A61K31/343 , A61K31/4525 , A61K31/496 , A61P33/06 , A61K31/553 , A61K31/5377 , A61K31/541
CPC分类号： C07D493/10 , C07D323/02 , C07D405/12 , C07D413/12
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公开(公告)号：EP4077308B1
公开(公告)日：2024-02-14
申请号：EP20830210.9
申请日：2020-12-18
发明人： PHILLIPS, Margaret , PALMER, Michael , CHARMAN, Susan A. , WATTS, Karl, Shawn , GERASYUTO, Aleksey I. , KRILOV, Goran
IPC分类号： C07D401/14 , C07D403/12 , C07D413/14 , A61K31/4439 , A61K31/4196 , A61P33/06 , C07D207/34
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公开(公告)号：EP2194985B1
公开(公告)日：2019-02-20
申请号：EP08837766.8
申请日：2008-10-08
发明人： YUTHAVONG, Yongyuth , VILAVAIN, Tirayut , KAMCHONWONGPAISAN, Sumalee , TARCHOMPOO, Bongkoch , THONGPANCHANG, Chawanee , CHITNUMSUB, Penchit , YUVANIYAMA, Jirundon , MATTHEWS, David , CHARMAN, Susan , CHARMAN, William , VIVAS, Livia , KATIYAR, Sanjay, Babu
IPC分类号： C07D239/48 , C07D401/04 , C07D401/12 , A61K31/495 , A61K31/496
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公开(公告)号：EP3137455B1
公开(公告)日：2018-08-15
申请号：EP15713170.7
申请日：2015-03-26
发明人： HAMEED PEER MOHAMED, Shahul , PATIL, Vikas , MURUGAN, Kannan , VITHALRAO BELLALE, Eknath , RAICHURKAR, Anandkumar , LANDGE, Sudhir , PUTTUR, Jayashree , ROY CHOUDHURY, Nilanjana , SHANBHAG, Gajanan , KOUSHIK, Krishna , IYER, Pravin , KIRTHIKA SAMBANDAMURTHY, Vasan , SOLAPURE, Suresh , NARAYANAN, Shridhar
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , A61P33/06
CPC分类号： C07D401/14 , A61K31/506 , A61K45/06 , C07D403/14 , Y02A50/411
摘要： The present invention relates to triaminopyrimidines and to pharmaceutically acceptable salts thereof, to their use in the treatment and/or prevention of malaria caused by plasmodium species, and to their methods of preparation.
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公开(公告)号：EP2526090A2
公开(公告)日：2012-11-28
申请号：EP11704673.0
申请日：2011-01-17
IPC分类号： C07D213/73 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/06 , A61K31/44 , A61K31/4427 , A61P33/06
CPC分类号： C07D213/73 , C07D213/74 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/04 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present invention is related to a use of aminopyridine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyridine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.
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公开(公告)号：EP3906225B1
公开(公告)日：2023-07-05
申请号：EP19829246.8
申请日：2019-12-30
发明人： SCHALKWIJK, Josephus , HERMKENS, Pedro Harold Han , DECHERING, Koen Jakob , BONNERT, Roger Victor
IPC分类号： C07C235/10 , A61P33/06 , A61P33/02
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9.发明公开SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES 有权替代物2-烷基-1-氧代-N-苯基-3-异辛基-1,2,3,4-四氢代环辛烯-4-羧酰胺F抗原抗体
公开(公告)号：EP2748147A1
公开(公告)日：2014-07-02
申请号：EP12772470.6
申请日：2012-08-24
申请人： St. Jude Children's Research Hospital , MMV Medicines for Malaria Venture , Rutgers, The State University Of New Jersey
发明人： GUY, Rodney Kiplin , ZHU, Fangyi , GUIGUEMDE, Wendyam Armand , FLOYD, David , KNAPP, Spencer , STEIN, Philip , CASTRO, Steve
IPC分类号： C07D217/26 , C07D401/04 , C07D405/04 , C07D413/04 , C07D417/04 , A61K31/47 , A61P33/06
CPC分类号： C07D401/04 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D409/04 , C07D417/04
摘要： In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl-,2,3,4-tetrahydroisoquinoline-4-carboxamides; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating and/or preventing malaria. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及新的取代的2-烷基-1-氧代-N-苯基-3-杂芳基-1,2,3,4-四氢异喹啉-4-甲酰胺; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及治疗和/或预防疟疾的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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公开(公告)号：EP2599779A1
公开(公告)日：2013-06-05
申请号：EP12153804.5
申请日：2004-08-11
发明人： Vennerstrom, Jonathan L. , Tang, Yuanqing , Dong, Yuxiang , Matile, Hugues , Charman, William N. , Chollet, Jacques , Padmanilayam, Maniyan , Yatendra, Kumar , Gyan, Chand Yadav
IPC分类号： C07D405/12 , C07D323/02 , C07D417/06 , C07D405/06 , A61P33/06 , A61K31/357 , A61K31/335 , A61K31/4747
CPC分类号： C07D405/06 , A61K31/335 , A61K31/4747 , C07D323/02 , C07D405/12 , C07D417/06 , Y02A50/411 , Y02A50/423
摘要： Dispiro 1,2,4-trioxolane, pharmaceutical formulation thereof, means and method for treating malaria, schistosomiasis, and cancer using a dispiro 1,2,4-trioxolane.
摘要翻译： 二螺环1,2,4-三恶烷，其药物制剂，使用脱甲基-1,2,4-三恶烷治疗疟疾，血吸虫病和癌症的手段和方法。
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