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公开(公告)号：EP2894731B1
公开(公告)日：2019-03-06
申请号：EP13835213.3
申请日：2013-09-02
申请人： Nagase & Co., Ltd.
IPC分类号： B29C45/14 , H01R43/048 , H01R43/24 , B29L31/34 , B29K705/00
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2.发明公开METHOD FOR PRODUCING MYCOSPORINE-LIKE AMINO ACID USING MICROBES 审中-公开VERFAHREN ZUR HERSTELLUNG VON MYCOSPORINE-likeAMINOSÄUREMITHILFE VON MIKROBEN
公开(公告)号：EP3144392A1
公开(公告)日：2017-03-22
申请号：EP15792252.7
申请日：2015-05-12
发明人： IKEDA, Haruo , YAMAMOTO, Shogo , MATSUMOTO, Jun , SOTA, Masahiro
IPC分类号： C12P13/04 , A61K8/44 , A61K8/99 , A61K31/198 , A61K35/74 , A61P17/02 , A61P17/16 , A61P35/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C249/14 , C07C251/20 , C12N15/09 , C12N1/21 , C12R1/465
CPC分类号： A61K8/44 , A61K8/99 , A61K31/198 , A61K35/00 , A61K36/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C249/14 , C07C251/20 , C07C2601/16 , C12N15/09 , C12P13/04 , C12R1/465 , Y02A50/473
摘要： Provided are: a method for producing a mycrosporine-like amino acid (MAA) that includes a step in which microbes are cultivated that produce MAA on the outside of bacterial cells, a step in which the bacterial cells and extracellular culture fluid are separated, and a step in which the MAA is recovered from the extracellular culture fluid; an MAA indicated by formula (1), an MAA produced using this method, or an ultraviolet-absorbing composition including the MAA indicated by formula (1); and a composition including the MAA produced using this method or the MAA indicated by formula (1), for preventing at least one symptom or disease selected from a group comprising acute skin reactions, aging of the skin, and skin cancer.
摘要翻译： 本发明提供：一种生产微孢子样样氨基酸（MAA）的方法，其包括在细菌细胞外产生MAA的培养微生物的步骤，细菌细胞和细胞外培养液分离的步骤，以及 从细胞外培养液中回收MAA的步骤; 由式（1）表示的MAA，使用该方法制备的MAA或包含式（1）所示的MAA的紫外线吸收组合物; 以及包含使用该方法制备的MAA或由式（1）表示的MAA的组合物，用于防止选自急性皮肤反应，皮肤老化和皮肤癌的组中的至少一种症状或疾病。
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3.发明公开PRODUCTION METHOD FOR BUS BAR INSERT RESIN MOLDED ARTICLE, AND BUS BAR INSERT RESIN MOLDED ARTICLE 审中-公开用于生产树脂形式的制品AS AS母线应用的母线应用及形态的树脂制品
公开(公告)号：EP2894731A4
公开(公告)日：2016-07-27
申请号：EP13835213
申请日：2013-09-02
申请人： NAGASE & CO LTD
发明人： ASANO NORISHIGE , NAKAZAWA TOSHIAKI
IPC分类号： B29C45/14 , B29K705/00 , B29L31/34 , H01R4/58 , H01R4/70 , H01R43/048 , H01R43/24
CPC分类号： H02G1/00 , B29C45/14221 , B29C45/14336 , B29K2705/00 , B29L2031/34 , B29L2031/3406 , H01R4/70 , H01R43/048 , H01R43/24 , H02G5/005
摘要： A method for manufacturing an insert-molded bus bar (50) includes the steps of: preparing a first bus bar (10) having a through hole (12) and a second bus bar (14) having a protrusion (16) corresponding to the through hole (12); preparing a mold (20) having therein a swaging member (30) capable of swaging the protrusion (16); placing the first and second bus bars (10, 14) in the mold (20) with the protrusion (16) being inserted into the through hole (12); swaging the first and second bus bars (10, 14) using the swaging member (30) of the mold (20) to obtain connected bus bars that are the bus bars connected to each other; and injecting a molding material (52) around the connected bus bars that are the bus bars connected to each other by swaging to perform insert molding using the mold (20) and obtain the insert-molded bus bar (50).
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4.发明公开NOVEL TERPENOID COMPOUND AND METHOD FOR PRODUCING SAME 审中-公开VERFAHREN ZUR HERSTELLUNG DAVON的中性型TERPENOIDVERBINDUNG
公开(公告)号：EP3034610A1
公开(公告)日：2016-06-22
申请号：EP14836017.5
申请日：2014-05-27
发明人： IKEDA, Haruo , SOTA, Masahiro
摘要： The present invention provides a novel terpenoid synthetase gene; a method of preparing a terpenoid compound, comprising introducing the novel terpenoid synthetase gene into a host cell to give a transformant, and culturing the transformant; and a novel terpenoid compound.
摘要翻译： 本发明提供了一种新型萜类合成酶基因; 一种制备萜类化合物的方法，包括将新的萜类合成酶基因引入宿主细胞中以产生转化体，并培养转化体; 和一种新型萜类化合物。
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5.发明公开METHOD OF PRODUCING OPTICALLY ACTIVE N-(HALOPROPYL)AMINO ACID DERIVATIVE 有权VERFAHREN ZUR HERSTELLUNG EINES OPTISCH AKTIVEN N-（HALOGENPROPYL）AMINOSÄUREDERIVATS
公开(公告)号：EP2192110A1
公开(公告)日：2010-06-02
申请号：EP08753110.9
申请日：2008-05-19
申请人： Nagase & Co., Ltd.
发明人： MATSUMOTO, Jun , INOUE, Toru
IPC分类号： C07C231/02 , C07C227/14 , C07C227/30 , C07C229/12 , C07C233/83 , C07C269/04 , C07C271/22 , C07B53/00
CPC分类号： C07B53/00 , C07B2200/07 , C07C229/12 , C07C233/83 , C07C271/22 , Y02P20/55
摘要： The present invention provides a method for producing an optically active N-(halopropyl)amino acid derivative, wherein the method comprises the steps of obtaining a compound represented by formula (III) by reacting an optically active alanine ester represented by formula (I) or a salt thereof (hereinafter sometimes simply referred to as an "alanine ester") with a halogenated propane represented by formula (II); and obtaining an optically active N-(halopropyl)amino acid derivative represented by formula (IV) by introducing a protecting group onto the nitrogen atom of the compound represented by formula (III). The present invention provides a method for efficiently producing an optically active N-(halopropyl)amino acid derivative.
摘要翻译： 本发明提供一种光学活性N-（卤代丙基）氨基酸衍生物的制造方法，其中，该方法包括以下步骤：通过使式（I）表示的光学活性丙氨酸酯或式 其盐（以下有时简称为“丙氨酸酯”）与式（II）表示的卤代丙烷; 通过在式（III）表示的化合物的氮原子上引入保护基，得到由式（Ⅳ）表示的光学活性的N-（卤代丙基）氨基酸衍生物。 本发明提供了有效制备光学活性N-（卤代丙基）氨基酸衍生物的方法。
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6.发明公开STAMPER ORIGINAL AND ITS MANUFACTURING METHOD, STAMPER AND ITS MANUFACTURING METHOD, AND OPTICAL DISK 审中-公开STANZERORIGINAL及其制造方法，冲床及其制备方法和光盘
公开(公告)号：EP1496510A1
公开(公告)日：2005-01-12
申请号：EP03717595.7
申请日：2003-04-15
申请人： Nagase & Co., Ltd.
发明人： OGAWA, Shu, c/o NAGASE & CO., LTD. , YAMANAKA, Shojiro, c/o NAGASE & CO., LTD. , KOSHINO, Sadafumi, c/o NAGASE & CO., LTD. , MIYAKE, Koji, c/o NAGASE & CO., LTD. , SANO, Kazuhiko,
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , G03F7/0017 , G11B7/261 , G11B7/263
摘要： An object of the present invention is to provide a stamper preform and others capable of obviating an Ni electroforming step taking a long time and readily producing a defective in production of a stamper and capable of forming an accurate and fine pattern of projections and indentations. A stamper preform 11 of the present invention has a base 1, a semi-crosslinked resist layer 2, and a prebaked resist layer 3 stacked in this order. The prebaked resist layer 3 contains a methoxymethyl melamine and bumps are readily formed therein by exposure and development (Fig. 1C).
摘要翻译： 本发明的一个目的是提供一种预成型压模，并且能够避免Ni电步骤花费很长的时间且容易地生产有缺陷的生产压模的和能够形成的突起和凹陷的准确和精细图案的他人。 本发明的压模预成型体11具有基体1，一个半交联抗蚀剂层2，和一个预烘烤的抗蚀剂以此顺序堆叠层3。 使预烘抗蚀剂层3含有一个甲氧基甲基三聚氰胺和凸块可以容易地通过曝光和显影（图1C）形成于其中。
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公开(公告)号：EP1282332A2
公开(公告)日：2003-02-05
申请号：EP02011776.8
申请日：2002-05-27
CPC分类号： B60R11/0217 , B60R11/0223 , B60R2011/0024 , B60R2011/0043 , H04R1/025 , H04R2201/021
摘要： The present invention provides a bracket for mounting a speaker that allows a speaker to be easily mounted and removed without impairing the acoustic characteristics of the speaker used for a specific use such as car audio equipment, and that can reduce the possibility of the speaker being damaged during mounting or removal. The bracket of the present invention includes a base plate; and a plurality of hooks that are provided on one face of the base plate and can engage with a part of an edge of a speaker frame in cooperation with a mounting member from the back of the speaker.
摘要翻译： 本发明提供一种用于安装扬声器的支架，其允许在不损害用于诸如汽车音频设备的特定用途的扬声器的声学特性的情况下容易地安装和移除扬声器，并且能够减少扬声器损坏的可能性 在安装或拆卸期间。 本发明的支架包括基板; 以及多个钩，其设置在基板的一个面上，并且能够与扬声器背面的安装构件协作而与扬声器框架的边缘的一部分接合。
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公开(公告)号：EP4385506A1
公开(公告)日：2024-06-19
申请号：EP22855796.3
申请日：2022-07-27
申请人： Nagase & Co., Ltd.
发明人： YAMAMOTO, Shogo
IPC分类号： A61K31/198 , A61K8/44 , A61K9/08 , A61K47/18 , A61K47/22 , A61K47/26 , A61P17/00 , A61P17/16 , A61P17/18 , A61Q17/00
CPC分类号： A61P17/00 , A61Q17/00 , A61K47/22 , A61K47/26 , A61K8/44 , A61P17/18 , A61K47/18 , A61K31/198 , A61K9/08 , A61P17/16
摘要： Provided are: a MG-stabilized composition which comprises mycosporine-glycine (MG) and is acidic to weakly alkaline; an MG-stabilized composition which comprises MG and at most 10 parts by weight of 4-DG; and an MAA-stabilized composition which comprises MAA and at least one selected from a base constituting a nucleic acid, a nucleoside, a glycine, and a tranexamic acid.
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公开(公告)号：EP3144392A4
公开(公告)日：2018-02-21
申请号：EP15792252
申请日：2015-05-12
申请人： THE KITASATO INST , NAGASE & CO LTD
发明人： IKEDA HARUO , YAMAMOTO SHOGO , MATSUMOTO JUN , SOTA MASAHIRO
IPC分类号： C12P13/04 , A61K8/44 , A61K8/99 , A61K31/198 , A61K35/74 , A61K36/064 , A61P17/02 , A61P17/16 , A61P35/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C249/14 , C07C251/20 , C12N1/21 , C12N15/09 , C12R1/465
CPC分类号： A61K8/44 , A61K8/99 , A61K31/198 , A61K35/00 , A61K36/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C249/14 , C07C251/20 , C07C2601/16 , C12N15/09 , C12P13/04 , C12R1/465
摘要： Provided are: a method for producing a mycrosporine-like amino acid (MAA) that includes a step in which microbes are cultivated that produce MAA on the outside of bacterial cells, a step in which the bacterial cells and extracellular culture fluid are separated, and a step in which the MAA is recovered from the extracellular culture fluid; an MAA indicated by formula (1), an MAA produced using this method, or an ultraviolet-absorbing composition including the MAA indicated by formula (1); and a composition including the MAA produced using this method or the MAA indicated by formula (1), for preventing at least one symptom or disease selected from a group comprising acute skin reactions, aging of the skin, and skin cancer.
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公开(公告)号：EP2873677A4
公开(公告)日：2016-04-27
申请号：EP13816363
申请日：2013-07-12
发明人： YOKOI HIDENORI , YOKOYAMA YASUHIRO , MATSUYAMA KEISUKE , YAMAMOTO KENICHIRO , ANZAI KINSEI , NAKAMURA DAISUKE , NAGANO TOYOHIRO , KODAMA KAZUYA
CPC分类号： C07K7/08 , A61K38/00 , C07K5/06043 , C07K5/06095 , C07K5/0808 , C07K5/0819 , C07K7/06
摘要： An object of the present invention is to provide a process capable of producing a self-assembling peptide derivative that is useful in the fields of regenerative medicine and surgery in large quantities and in an economical and efficient manner. In particular, provided is a production process employing a combination of (i) a step of convergently constructing a sequence with use of a common repeating unit consisting of a specific amino acid sequence and (ii) a step of first isolating the peptide derivative as a disulfuric acid salt, a tetramethanesulfonic acid salt or a tetra(trifluoroacetic acid (TFA) salt), and then subjecting the peptide salt to a salt exchange reaction to yield a tetrahydrochloric acid salt.
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