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公开(公告)号：EP3148568A4
公开(公告)日：2018-01-17
申请号：EP15800695
申请日：2015-05-28
申请人： NONO INC
CPC分类号： A61K9/19 , A61K9/0019 , A61K38/00 , A61K38/10 , A61K47/183 , A61K47/26 , C07K14/16 , C07K14/70571 , C07K2319/10
摘要： The present invention provides lyophilized formulations of active agents, particularly of TAT-NR2B9c including histidine, trehalose and lysine. TAT-NR2B9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. Such formulations are stable at ambient temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene of illness or accident or in transit to a hospital.
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公开(公告)号：EP2521724B1
公开(公告)日：2016-11-23
申请号：EP10836790.5
申请日：2010-12-10
申请人： Nono Inc.
IPC分类号： C07D417/04 , C07D409/06 , C07D403/06 , C07D311/18 , C07D333/60 , A61K31/427 , A61K31/428 , A61P9/00 , A61P13/12 , A61P35/00
CPC分类号： A61K31/551 , A61K31/122 , A61K31/353 , A61K31/381 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4704 , A61K31/4709 , A61K31/4725 , A61K31/496 , C07D209/08 , C07D215/08 , C07D215/233 , C07D277/36 , C07D277/82 , C07D311/18 , C07D333/38 , C07D333/60 , C07D339/00 , C07D403/06 , C07D409/04 , C07D409/06 , C07D417/04 , C40B40/04 , G01N33/6872 , G01N2510/00
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公开(公告)号：EP2723363A4
公开(公告)日：2014-12-10
申请号：EP12802409
申请日：2012-06-23
申请人： NONO INC
发明人： TYMIANSKI MICHAEL
CPC分类号： A61K38/10 , A61K38/1787 , A61K38/49 , A61K2300/00
摘要： The invention provides a combination treatment for ischemia conditions in or otherwise affecting the CNS, such as stroke. The treatment invoices administration of a PSD-95 inhibitor and performing reperfusion therapy (e.g. by administration of tPA). Administration a PSD-95 inhibitor in combination with reperfusion therapy increases the efficacy of the reperfusion therapy and/or slows the decline in efficacy of reperfusion therapy with time after onset of ischemia thus extending the window in which reperfusion therapy can be administered.
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公开(公告)号：EP2720695A4
公开(公告)日：2014-11-12
申请号：EP12800164
申请日：2012-06-15
申请人： NONO INC
发明人： SUN XIUJUN , TYMIANSKI MICHAEL , GARMAN DAVID
IPC分类号： A61K31/381 , A61K31/38 , A61K31/435 , A61P9/00 , A61P9/10
CPC分类号： C07D311/20 , C07D215/227 , C07D311/58 , C07D333/70 , C07D409/06 , C07D409/12
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公开(公告)号：EP2521724A4
公开(公告)日：2013-11-06
申请号：EP10836790
申请日：2010-12-10
申请人： NONO INC
IPC分类号： C07D417/04 , A61K31/427 , A61K31/428 , A61P9/00 , A61P13/12 , A61P35/00 , C07D311/18 , C07D333/60 , C07D403/06 , C07D409/06
CPC分类号： A61K31/551 , A61K31/122 , A61K31/353 , A61K31/381 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4704 , A61K31/4709 , A61K31/4725 , A61K31/496 , C07D209/08 , C07D215/08 , C07D215/233 , C07D277/36 , C07D277/82 , C07D311/18 , C07D333/38 , C07D333/60 , C07D339/00 , C07D403/06 , C07D409/04 , C07D409/06 , C07D417/04 , C40B40/04 , G01N33/6872 , G01N2510/00
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公开(公告)号：EP2175873A2
公开(公告)日：2010-04-21
申请号：EP08772390.4
申请日：2008-07-02
申请人： Nono, Inc. , Arbor Vita Corporation
发明人： TASKER, Andrew , DOUCETTE, Tracy , TYMIANSKI, Michael , MENDOZA, Kenneth , BELMARES, Michael, P. , GARMAN, David , LU, Peter, S.
CPC分类号： A61K38/1787 , A61K38/07
摘要： The invention provides methods of treating or effecting prophylaxis of a patient having or at risk of developing symptoms of anxiety in which an effective regime of an agent that inhibits specific binding of PSD95 to an NMDA receptor is administered to a patient.
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公开(公告)号：EP2334315B1
公开(公告)日：2023-01-18
申请号：EP09812187.4
申请日：2009-09-02
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公开(公告)号：EP2175873B1
公开(公告)日：2015-11-11
申请号：EP08772390.4
申请日：2008-07-02
申请人： NoNO Inc.
发明人： TASKER, Andrew , DOUCETTE, Tracy , TYMIANSKI, Michael , MENDOZA, Kenneth , BELMARES, Michael, P. , GARMAN, David , LU, Peter, S.
CPC分类号： A61K38/1787 , A61K38/07
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10.发明授权
公开(公告)号：EP2229185B1
公开(公告)日：2015-10-07
申请号：EP08859906.3
申请日：2008-12-02
申请人： NoNO Inc.
IPC分类号： A61K47/42
CPC分类号： A61K38/1787 , A61K9/0019 , A61K31/56 , A61K38/08 , A61K45/06 , A61K47/645 , A61K2300/00
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