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公开(公告)号：EP2175873A2
公开(公告)日：2010-04-21
申请号：EP08772390.4
申请日：2008-07-02
申请人： Nono, Inc. , Arbor Vita Corporation
发明人： TASKER, Andrew , DOUCETTE, Tracy , TYMIANSKI, Michael , MENDOZA, Kenneth , BELMARES, Michael, P. , GARMAN, David , LU, Peter, S.
CPC分类号： A61K38/1787 , A61K38/07
摘要： The invention provides methods of treating or effecting prophylaxis of a patient having or at risk of developing symptoms of anxiety in which an effective regime of an agent that inhibits specific binding of PSD95 to an NMDA receptor is administered to a patient.
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2.发明公开CO-ADMINISTRATION OF AN AGENT LINKED TO AN INTERNALIZATION PEPTIDE WITH AN ANTI-INFLAMMATORY 有权意味着同时给药以A内在TAT肽相连，抗炎剂
公开(公告)号：EP2229185A2
公开(公告)日：2010-09-22
申请号：EP08859906.3
申请日：2008-12-02
申请人： Nono, Inc. , Arbor Vita Corporation
IPC分类号： A61K47/42
CPC分类号： A61K38/1787 , A61K9/0019 , A61K31/56 , A61K38/08 , A61K45/06 , A61K47/645 , A61K2300/00
摘要： The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.
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3.发明公开POLYPEPTIDES FOR MODULATING BINDING OF TRP CHANNEL PROTEINS AND TRP-ASSOCIATED PROTEINS 审中-公开多肽调制的TRP通道蛋白和TRP相关蛋白结合
公开(公告)号：EP1709084A1
公开(公告)日：2006-10-11
申请号：EP04802368.3
申请日：2004-12-22
申请人： Nono Inc. , Arbor Vita Corporation
IPC分类号： C07K19/00 , G01N33/566 , C07K7/00 , C07K14/155 , C07K14/705 , C07H21/00 , C07H21/02 , A61K38/17 , A61K38/04 , A61K47/42 , A61K48/00 , A61K31/7105
CPC分类号： C12N15/1138 , A61K38/00 , C07K14/47 , C07K14/705 , C07K2319/10 , C12N2799/022 , G01N2500/00
摘要： This invention relates to inhibitors and modulators of the binding between a transcient receptor potential (TRP) channel protein and a TRP-associated binding protein. In particular inhibitors and modulators of the binding between the TRPM7 channel protein and PDZ-domain containing TRP-associated proteins. These modulators and inhibitors are used to control Ca2+ transport through TRPM7 channel proteins and reduce damage to mammalian cells, including brain and spinal cord cells, after ischemia or traumatic injury.
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公开(公告)号：EP2307035A2
公开(公告)日：2011-04-13
申请号：EP09747499.3
申请日：2009-05-13
申请人： Arbor Vita Corporation , Nono, Inc.
IPC分类号： A61K38/00
CPC分类号： A61K38/1787 , A61K45/06 , C07K2319/10 , A61K2300/00
摘要： The invention provides methods of treating a patient having epilepsy in which an effective regime of an agent that inhibits specific binding of PSD-95 to an NMDA receptor is administered to a patient.
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公开(公告)号：EP2334315A2
公开(公告)日：2011-06-22
申请号：EP09812187.4
申请日：2009-09-02
申请人： Arbor Vita Corporation , Nono, Inc.
发明人： BELMARES, Michael P. , GARMAN, J. David , LU, Peter S. , SALTER, Michael W. , TYMIANSKI, Michael
IPC分类号： A61K38/00
摘要： The invention provides agents useful for treating pain. An exemplary agent comprises or consists of the a portion of a retroviral Tat protein. One such agent is the peptide Tat-NR2B9c. This peptide has previously been described as an agent for inhibiting damaging effects of stroke and similar conditions via inhibition of PSD95 interactions with NMDA receptors and/or NOS. The present application provides data showing that the Tat-NR2B9c peptides is effective in alleviation of pain. The alleviation of pain can be obtained at a dose of the peptide below the dose required to inhibit PSD-95 interactions with NMDAR or NOS.
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6.发明公开
公开(公告)号：EP2120987A1
公开(公告)日：2009-11-25
申请号：EP08726313.3
申请日：2008-02-29
申请人： Arbor Vita Corporation , Nono Inc.
发明人： BELMARES, Michael, P. , GARMAN, Jonathan, David , LU, Peter, S. , SALTER, Michael, W. , TYMIANSKI, Michael
IPC分类号： A61K38/00 , A61K38/04 , A61K38/10 , A61K38/16 , C07K14/435
CPC分类号： A61K47/48246 , A61K38/00 , A61K47/645 , C07K7/06 , C07K14/70571 , C07K2319/10
摘要： The invention provides methods for treating stroke and compositions for use in the same. The methods employ a chimeric peptide pf an active peptide and an internalization peptide. The internalization peptide is a tat variant that promotes uptake of itself and a linked active peptide into a cell without substantial binding to N-type calcium channels. Use of the tat variant allows treating of stroke free of certain side effects associated with binding to N-type calcium channels. Tat variant peptides can also be linked to other active agent for use in treating other diseases.
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公开(公告)号：EP2043671A2
公开(公告)日：2009-04-08
申请号：EP07796769.3
申请日：2007-07-11
申请人： Arbor Vita Corporation , Nono Inc.
发明人： TYMIANSKI, Michael
IPC分类号： A61K38/07 , A61K38/08 , A61K38/09 , A61K38/10 , A61K38/16 , C07K14/00 , C07K7/04 , C07K7/06 , C07K7/08 , C07K5/00
CPC分类号： A61K38/08 , A61K38/07 , A61K38/177 , G01N33/5088 , G01N2500/02 , G01N2800/042 , G01N2800/2871
摘要： The invention provides methods of treating stroke and related conditions exacerbated by fever and/or hyperglycemi by administering peptides or peptidomimetics that inhibit binding of NMDAR 2B to PSD-95 to a patient.
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公开(公告)号：EP2521724B1
公开(公告)日：2016-11-23
申请号：EP10836790.5
申请日：2010-12-10
申请人： Nono Inc.
IPC分类号： C07D417/04 , C07D409/06 , C07D403/06 , C07D311/18 , C07D333/60 , A61K31/427 , A61K31/428 , A61P9/00 , A61P13/12 , A61P35/00
CPC分类号： A61K31/551 , A61K31/122 , A61K31/353 , A61K31/381 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4704 , A61K31/4709 , A61K31/4725 , A61K31/496 , C07D209/08 , C07D215/08 , C07D215/233 , C07D277/36 , C07D277/82 , C07D311/18 , C07D333/38 , C07D333/60 , C07D339/00 , C07D403/06 , C07D409/04 , C07D409/06 , C07D417/04 , C40B40/04 , G01N33/6872 , G01N2510/00
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