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公开(公告)号：EP3066923A2
公开(公告)日：2016-09-14
申请号：EP16161784.0
申请日：2007-01-26
发明人： CHAN, Keith , TOWN, Winston
IPC分类号： A01N55/02 , A61K31/295 , A61K33/26 , A61P13/12 , A61K9/14
CPC分类号： A61K31/295 , A61K9/143 , A61K31/555 , A61K33/26
摘要： The present invention discloses pharmaceutical-grade ferric organic compounds having enhanced dissolution rate. These ferric organic compounds, including but are not limited to ferric citrate, are useful for treating chronic kidney disease.
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公开(公告)号：EP2813511A2
公开(公告)日：2014-12-17
申请号：EP14173782.5
申请日：2004-02-18
IPC分类号： C07F15/02 , A01N37/00 , A61K31/295 , C07C59/265 , C07C51/41
CPC分类号： C07F15/025 , A61K31/295 , C07C51/41 , C07C51/412 , C07C51/418 , C07C59/265 , C07F15/02 , C07C55/10 , C07C59/255 , C07C53/08 , C07C59/245 , C07C57/15
摘要： The present invention is directed to forms of ferric organic compounds, uses thereof, and methods of making same. The present invention discloses a novel physical form of ferric citrate with dissolution properties desirable for use in medicine, including the treatment of hyperphosphatemia and metabolic acidosis.
摘要翻译： 本发明涉及铁有机化合物的形式，其用途及其制备方法。 本发明公开了具有希望用于医学的溶解性质的柠檬酸铁的新型物理形式，包括治疗高磷酸盐血症和代谢性酸中毒。
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3.发明公开
公开(公告)号：EP2813511A3
公开(公告)日：2014-12-31
申请号：EP14173782.5
申请日：2004-02-18
IPC分类号： C07F15/02 , A01N37/00 , A61K31/295 , C07C59/265 , C07C51/41
CPC分类号： C07F15/025 , A61K31/295 , C07C51/41 , C07C51/412 , C07C51/418 , C07C59/265 , C07F15/02 , C07C55/10 , C07C59/255 , C07C53/08 , C07C59/245 , C07C57/15
摘要： The present invention is directed to forms of ferric organic compounds, uses thereof, and methods of making same. The present invention discloses a novel physical form of ferric citrate with dissolution properties desirable for use in medicine, including the treatment of hyperphosphatemia and metabolic acidosis.
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公开(公告)号：EP3066923A3
公开(公告)日：2016-10-19
申请号：EP16161784.0
申请日：2007-01-26
发明人： CHAN, Keith , TOWN, Winston
IPC分类号： A01N55/02 , A61K31/295 , A61K33/26 , A61P13/12 , A61K9/14
CPC分类号： A61K31/295 , A61K9/143 , A61K31/555 , A61K33/26
摘要： The present invention discloses pharmaceutical-grade ferric organic compounds having enhanced dissolution rate. These ferric organic compounds, including but are not limited to ferric citrate, are useful for treating chronic kidney disease.
摘要翻译： 本发明公开了溶解速率提高的药物级铁有机化合物。 这些铁有机化合物，包括但不限于柠檬酸铁，可用于治疗慢性肾病。
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5.发明授权METHODS OF MAKING FERRIC ORGANIC COMPOUNDS 有权VERFAHREN ZUR HERSTELLUNG VON EISENHALTIGEn ORGANISCHE VERBINDUNGEN
公开(公告)号：EP1601680B8
公开(公告)日：2014-11-26
申请号：EP04712312.0
申请日：2004-02-18
IPC分类号： C07F15/02 , A01N37/00 , A61K31/295 , C07C51/41 , C07C59/265
CPC分类号： C07F15/025 , A61K31/295 , C07C51/41 , C07C51/412 , C07C51/418 , C07C59/265 , C07F15/02 , C07C55/10 , C07C59/255 , C07C53/08 , C07C59/245 , C07C57/15
摘要： The present invention is directed to forms of ferric organic compounds, uses thereof, and methods of making same. The present invention discloses a novel physical form of ferric citrate with dissolution properties desirable for use in medicine, including the treatment of hyperphosphatemia and metabolic acidosis.
摘要翻译： 本发明涉及三价铁有机化合物的形式，其用途及其制备方法。 本发明公开了一种新型物理形式的柠檬酸柠檬酸盐，具有理想的用于药物的溶解性质，包括治疗高磷血症和代谢性酸中毒。
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公开(公告)号：EP1978807B1
公开(公告)日：2016-03-23
申请号：EP07717051.2
申请日：2007-01-26
发明人： CHAN, Keith , TOWN, Winston
IPC分类号： A01N55/02 , A61K31/295 , A61K33/26 , A61P13/12
CPC分类号： A61K31/295 , A61K9/143 , A61K31/555 , A61K33/26
摘要： The present invention discloses pharmaceutical-grade ferric organic compounds having enhanced dissolution rate. These ferric organic compounds, including but are not limited to ferric citrate, are useful for treating chronic kidney disease.
摘要翻译： 本发明公开了具有增强的溶解速率的药物级铁有机化合物。 这些铁有机化合物，包括但不限于柠檬酸铁，可用于治疗慢性肾脏疾病。
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7.发明公开Uses of pharmaceutical-grade ferric organic compounds 审中-公开Verwendungen von eisenhaltigen organischen Verbindungen pharmazeutischerQualität
公开(公告)号：EP2594551A1
公开(公告)日：2013-05-22
申请号：EP12192822.0
申请日：2006-08-18
发明人： Chan, Keith , Town, Winston
IPC分类号： C07C51/42 , C07C51/41 , A61K31/295 , A61P13/12
CPC分类号： A61K31/295 , C07C51/412 , C07C51/42 , C07C59/265
摘要： The present invention discloses apharmaceutical-grade ferric organic compounds, including ferric citrate, which are soluble over a wider range of pH, and which have a large active surface area. A manufacturing and quality control process for making a pharmaceutical-grade ferric citrate that consistently complies with the established Manufacture Release Specification is also disclosed. The pharmaceutical-grade ferric organic compounds are suitable for treating disorders characterized by elevated serum phosphate levels.
摘要翻译： 本发明公开了包括柠檬酸铁在内的药物级三价铁有机化合物，其可在更宽的pH范围内溶解并具有大的活性表面积。 还公开了制造和质量控制过程，用于制造符合既定制造版本规范的药用级柠檬酸铁。 药物级铁有机化合物适用于治疗以血清磷酸盐水平升高为特征的疾病。
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公开(公告)号：EP4378456A1
公开(公告)日：2024-06-05
申请号：EP21951329.8
申请日：2021-07-30
发明人： CHUANG, Jwey Yuan , SU, Yu De , LU, Shao Chuan
摘要： A two-layer controlled-release oral preparation, which comprises a first ingredient as a quick-release layer and a second ingredient as a controlled-release layer, wherein the first ingredient comprises a xanthine derivative, and the second ingredient comprises a xanthine derivative and an enteric excipient. No more than 35% by weight of the xanthine derivative in the second ingredient is released within 90 min after in vitro elution, and 50% or more by weight of the xanthine derivative in the second ingredient is released within 3 h after in vitro elution.
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9.发明授权
公开(公告)号：EP1978808B1
公开(公告)日：2018-08-29
申请号：EP07762833.7
申请日：2007-01-26
发明人： CHAN, Keith , TOWN, Winston , CHIANG, Shou Shan
CPC分类号： A61K31/295 , A61K9/143 , A61K31/555 , A61K33/26
摘要： The present invention discloses pharmaceutical-grade ferric organic compounds having enhanced dissolution rate. These ferric organic compounds, including but are not limited to ferric citrate, are useful for treating chronic kidney disease.
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10.发明授权Pharmaceutical-grade ferric citrate for medical use 有权Eisencitrat在Arzneimittelqualitätzur medizinischen Verwendung
公开(公告)号：EP1931689B1
公开(公告)日：2015-02-25
申请号：EP06813544.1
申请日：2006-08-18
发明人： CHAN, Keith , TOWN, Winston
IPC分类号： C07C51/42 , C07C51/41 , A61K31/295 , A61P13/12
CPC分类号： A61K31/295 , C07C51/412 , C07C51/42 , C07C59/265
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