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1.发明公开
公开(公告)号：EP3511029A1
公开(公告)日：2019-07-17
申请号：EP17848932.4
申请日：2017-03-22
发明人： KIM, Ik Soo , KIM, Han Gyu , LEE, Su Yeon
摘要： The present invention relates to a dermal layer which is for grafting and has an improved graft survival rate, and a method for producing the same, wherein the dermal layer for grafting can be produced by filling a filling solution, including a DNA fragment mixture and chitosan, into an acellular dermal matrix from which cells have been removed. It was observed that the dermal layer for grafting produced in this manner, due to the filling solution filled therein and including a DNA fragment mixture and chitosan, increases the rate at which cells flow in from the tissue surrounding the graft and are fixed, and thereby alleviates an initial inflammatory reaction and promotes blending with the surrounding tissue.
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公开(公告)号：EP3505189A1
公开(公告)日：2019-07-03
申请号：EP16914310.4
申请日：2016-12-29
发明人： KIM, Ik Soo , KIM, Han Gyu , LEE, Su Yeon
IPC分类号： A61K48/00 , A61K31/722 , A61K31/711 , A61K9/00 , A61K47/36 , A61K47/40
摘要： The present invention relates to a composition for articular cavity injection comprising a nucleic acid and chitosan. More specifically, in the present invention, it was confirmed that the sol-gel transition occurred depending on the temperature in the composition for articular cavity injection prepared through the mixing of the nucleic acid and chitosan, the proteoglycan biosynthesis of the cartilage tissue was increased by the injection of the composition and the cartilage regeneration effect was exhibited, and the pain was alleviated and the walking speed and stride which are the joint motilities were improved. Therefore, development of a therapeutic agent for arthritis having an excellent therapeutic effect using the composition for articular cavity injection comprising the nucleic acid and chitosan of the present invention is expected.
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公开(公告)号：EP3412313A1
公开(公告)日：2018-12-12
申请号：EP16889476.4
申请日：2016-02-29
发明人： KIM, Ik Soo , KIM, Han Gyu , HONG, Cheol Am , LEE, Su Yeon
IPC分类号： A61K47/36 , A61K31/7088 , C08L5/08 , C08J3/075
摘要： The present invention provides a temperature sensitive hydrogel composition including a nucleic acid and chitosan. Since the hydrogel has excellent biocompatibility and biostability, and simultaneously has sol-gel phase transition properties depending on temperature changes, the hydrogel is present in a sol state at room temperature and becomes a gel when the hydrogel is injected into the human body or applied on the surface of epithelial skin and the temperature increases. Thus, the temperature-sensitive hydrogel of the present invention can be directly injected into and applied on certain parts requiring treatment and the retention and attaching time of a drug is increased through gelation depending on the temperature so that drug efficacy is sufficiently exhibited. Therefore, it is expected that the temperature-sensitive hydrogel of the present invention can be utilized for various treatments.
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公开(公告)号：EP3412313B1
公开(公告)日：2020-08-26
申请号：EP16889476.4
申请日：2016-02-29
发明人： KIM, Ik Soo , KIM, Han Gyu , HONG, Cheol Am , LEE, Su Yeon
IPC分类号： A61K9/08 , A61K47/36 , A61K31/7088
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公开(公告)号：EP2783702B1
公开(公告)日：2018-11-14
申请号：EP12851320.7
申请日：2012-11-21
发明人： AH, Young Chang , CHO, Sung Yeon , HWANG, In Seok , PARK, Sun Young , KO, Hyun Ju , KIM, Hyuk , KWON, Min Jung , PARK, Won Seok
CPC分类号： C08L5/08 , A61K9/06 , A61K47/36 , A61L15/28 , A61L27/20 , A61L2400/06 , C08B37/0072
摘要： The invention, provides a method for preparing a water insoluble gel composition comprising: mixing a water soluble an epoxy cross-linking agent, an alkaline compound and a solvent; and drying the thus mixture at 1 to 30°C under vacuum to remove the solvent, and a water insoluble gel composition.
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6.发明公开COMPOSITION FOR PREVENTING OR TREATING ISCHEMIC ENTERITIS CONTAINING DNA FRAGMENT MIXTURE ISOLATED FROM SPERM OR TESTIS OF FISH 审中-公开用于预防或治疗由精子或睾丸分离的含有DNA片段混合物的缺血性肠杆菌的组合物
公开(公告)号：EP3315135A1
公开(公告)日：2018-05-02
申请号：EP16814593.6
申请日：2016-05-25
发明人： KIM, Ik Soo , BAEK, Seung Gul , KIM, Chang Ju , JEON, Jung Won
CPC分类号： A61K35/60 , A61K9/0019 , A61K9/08 , A61K31/711 , A61K47/02 , A61K48/00 , A61P1/00
摘要： The present invention relates to a composition for preventing or treating ischemic enteritis containing a DNA fragment mixture isolated from sperm or testis of fish. The composition of the present invention was verified to have excellent effects in the prevention or treatment of ischemic enteritis. In addition, the composition for preventing or treating ischemic enteritis of the present invention was verified to be safe and have few side effects even when administered for a long period of time. Therefore, a medicine for ischemic enteritis, which is safe without side effects and has an excellent treatment effect, is developed by using the composition for preventing or treating ischemic enteritis of the present invention, and thus the composition of the present invention is expected to be a great help in the treatment of ischemic enteritis.
摘要翻译： 本发明涉及用于预防或治疗缺血性肠炎的组合物，其含有从鱼的精子或睾丸分离的DNA片段混合物。 证实本发明的组合物在预防或治疗缺血性肠炎方面具有优异的效果。 另外，本发明的用于预防或治疗缺血性肠炎的组合物被证实是安全的，并且即使长时间给药也具有很少的副作用。 因此，通过使用本发明的缺血性肠炎预防或治疗用组合物，开发了无副作用且治疗效果优异的缺血性肠炎药物，从而期待本发明的组合物 对缺血性肠炎的治疗有很大的帮助。
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