公开(公告)号：EP2130908A3

公开(公告)日：2010-01-06

申请号：EP09011765.6

申请日：2007-08-28

申请人： REINNERVATE LIMITED

发明人： Przyborski, Stefan ,  Whiting, Andrew ,  Marder, Todd

IPC分类号： C12N5/00 ,  C07C63/66 ,  C07C57/50 ,  C07C259/10 ,  A61K31/235 ,  A61K31/216

CPC分类号： C12N5/0606 ,  A61K31/216 ,  A61K31/235 ,  C07C57/50 ,  C07C63/66 ,  C12N2501/385

摘要： The invention relates to retinoid compounds of the formula

or

or a salt thereof, and to the use of such compounds in the control of cell differentiation.

公开(公告)号：EP2130908A2

公开(公告)日：2009-12-09

申请号：EP09011765.6

申请日：2007-08-28

申请人： REINNERVATE LIMITED

发明人： Przyborski, Stefan ,  Whiting, Andrew ,  Marder, Todd

IPC分类号： C12N5/00 ,  C07C63/66 ,  C07C57/50 ,  C07C259/10 ,  A61K31/235 ,  A61K31/216

CPC分类号： C12N5/0606 ,  A61K31/216 ,  A61K31/235 ,  C07C57/50 ,  C07C63/66 ,  C12N2501/385

摘要： The invention relates to retinoid compounds of the formula (I):

wherein
V is a hydrophobic group;
W is a non-polyenic linker; and
X is a polar group comprising a hydrogen bond donor;
or a salt thereof, and to the use of such compounds in the control of cell differentiation.

摘要翻译： 本发明涉及下式的类视黄醇化合物或其盐，以及这些化合物在控制细胞分化中的用途。

公开(公告)号：EP2054504A2

公开(公告)日：2009-05-06

申请号：EP07804055.7

申请日：2007-08-28

申请人： REINNERVATE LIMITED

发明人： PRZYBORSKI, Stefan ,  WHITING, Andrew ,  MARDER, Todd

IPC分类号： C12N5/00 ,  C07C63/66 ,  C07C57/50 ,  C07C259/10 ,  A61K31/235 ,  A61K31/216

CPC分类号： C12N5/0606 ,  A61K31/216 ,  A61K31/235 ,  C07C57/50 ,  C07C63/66 ,  C12N2501/385

摘要： The invention relates to retinoid compounds of one of the following formulae: Formula 6 a; R = H D1 R = Me (i) PaIa-CO2R' QC = H or Me) (ii)Imeta-CO2R' (R' = H or Me) (iii) ortho-CO2R' (R1 = H or Me) Formula 10 a,R = H b; R = Me (i) PaIa-CO2R' QC = H or Me) (ii)Imeta-CO2R' (R' = H or Me) (iii) ortho-CO2R' (R1 = H or Me) Formula 11 a; R = H b; R =Me (i) para-CONHOH (u)meta-CONHOH (ui)orttho-CONH0H Formula 12 (i) PaIa-CO2H (R = H or Me. R' = H or Me) (ii) meta-CO2H (R = H or Me, R' = H orM) Formula 13 R = H or Me, R' = H or M or a salt thereof, and to the use of such compounds in the control of cell differentiation.

公开(公告)号：EP2018418B1

公开(公告)日：2014-12-10

申请号：EP07732504.1

申请日：2007-04-24

申请人： REINNERVATE LIMITED

发明人： PRZYBORSKI, Stefan Alexander ,  CAMERON, Neil

IPC分类号： C12N5/00

CPC分类号： C12N5/0068 ,  C12M25/14 ,  C12N5/0671 ,  C12N2533/30

公开(公告)号：EP2018418A1

公开(公告)日：2009-01-28

申请号：EP07732504.1

申请日：2007-04-24

申请人： REINNERVATE LIMITED

发明人： PRZYBORSKI, Stefan, Alexander ,  CAMERON, Neil

IPC分类号： C12N5/00

CPC分类号： C12N5/0068 ,  C12M25/14 ,  C12N5/0671 ,  C12N2533/30

摘要： We describe a cell culture substrate comprising a polymerised high internal phase emulsion polymer adapted and modified for use in the routine culture of cells in three dimensions; typically mammalian cells and the use of the substrate in a cell culture system for investigation and analysis of proliferation, differentiation and function of cells.