-
公开(公告)号：EP2521541A2
公开(公告)日：2012-11-14
申请号：EP10830476.7
申请日：2010-10-28
IPC分类号： A61K31/16 , A61K31/165 , A61K31/185 , A61P35/00 , A61P17/00
CPC分类号： A61K31/167
摘要： Provided in certain embodiments herein are methods of prophylaxis of skin cancer in individuals having a heightened risk of skin cancer with a fenretinide agent.
-
公开(公告)号：EP2205234A4
公开(公告)日：2010-12-22
申请号：EP08834564
申请日：2008-09-16
发明人： MATA NATHAN L , PHAN KIM B , BUI TAM V , HADDACH MUSTAPHA
IPC分类号： A61K31/167 , A61K31/203 , A61K31/21 , A61P27/02
CPC分类号： A61K31/20 , A61K31/167 , A61K31/21
-
公开(公告)号：EP2648711A2
公开(公告)日：2013-10-16
申请号：EP11847841.1
申请日：2011-12-05
发明人： EDGAR, Mark , LICHTER, Jay , MATA, Nathan L.
IPC分类号： A61K31/16 , A61K31/164 , A61K31/17 , A61P27/02
CPC分类号： A61K31/167 , A61K9/145 , A61K9/4858
摘要： Compositions of novel fenretinide powders that reduce serum RBP, and/or serum retinol- RBP levels are used to treat ophthalmic conditions such as geographic atrophy (GA), an advanced form of dry AMD and the prevention of choroidal neovascularization (CNV, or wet AMD).
-
4.发明公开Retinol binding protein and transthyretin modulators for treating hypertosis, Alzheimer's disease or idiopathic intracranial hypertension 审中-公开视黄醇结合蛋白与蛋白 - 蛋白 - 丝氨酸蛋白 - 调节素Zur Behandlung von升血，Morbus阿尔茨海默病痴呆症颅内高血压
公开(公告)号：EP2289500A1
公开(公告)日：2011-03-02
申请号：EP10181763.3
申请日：2005-12-07
发明人： Widder, Kenneth , Lichter, Jay
IPC分类号： A61K31/165 , A61P9/00 , A61P25/28
CPC分类号： A61K31/165 , A61K31/16 , A61K31/56 , A61K45/06 , G01N2800/042 , G01N2800/164 , A61K2300/00
摘要： Described herein are methods and compositions for treating certain retinol-related diseases and conditions by modulation of transthyretin (TTR) and retinol binding protein (RBP) availability in the subject. For example, the methods and compositions provide for therapeutic agents for the treatment and/or prevention of age-related macular degeneration and/or dystrophies, metabolic disorders, idiopathic intracranial hypertension, hyperostosis, and protein misfolding and aggregation diseases. The compositions disclosed may be used as single agent therapy or in combination with other agents or therapies. In addition, described herein are methods and assays for selecting appropriate agents that can modulate the TTR and RBP availability in a subject.
摘要翻译： 本文描述了通过调节受试者中转甲状腺素蛋白（TTR）和视黄醇结合蛋白（RBP）可用性来治疗某些视黄醇相关疾病和病症的方法和组合物。 例如，所述方法和组合物提供用于治疗和/或预防年龄相关性黄斑变性和/或营养不良，代谢紊乱，特发性颅内高血压，骨质增生和蛋白质错误折叠和聚集疾病的治疗剂。 所公开的组合物可以用作单一药物治疗或与其它药物或疗法组合使用。 此外，本文描述了用于选择可以调节受试者的TTR和RBP可用性的适当试剂的方法和测定。
-
公开(公告)号：EP2277516A1
公开(公告)日：2011-01-26
申请号：EP10181656.9
申请日：2005-06-06
发明人： Widder, Kenneth , Lichter, Jay , Mata, Nathan, L.
IPC分类号： A61K31/167 , A61P27/02
CPC分类号： A61K31/167 , A61K31/16 , A61K31/215 , G01N2800/164
摘要： Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.
-
公开(公告)号：EP2217589A2
公开(公告)日：2010-08-18
申请号：EP08854518.1
申请日：2008-11-26
发明人： MATA, Nathan, L. , REID, Silvia, N. , PHAN, Kim, B. , HAN, Yun , BUI, Tam, V. , HADDACH, Mustapha
IPC分类号： C07D401/12
CPC分类号： C07D211/94 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14
摘要： Described herein are compounds, compositions and methods directed to the treatment of ophthalmic conditions characterized by oxidative stress or damage in a subject by reducing the reactive oxygen species in the subject. Also described herein are methods for reducing ophthalmic photooxidative damage in a subject.
-
-
公开(公告)号：EP2427052A1
公开(公告)日：2012-03-14
申请号：EP10772657.2
申请日：2010-05-03
CPC分类号： A61K31/202
摘要： We describe methods and compositions for treating ophthalmic conditions associated with angiogenesis, vascular leakage, and/or damage to ganglia.
-
公开(公告)号：EP2217589A4
公开(公告)日：2012-02-22
申请号：EP08854518
申请日：2008-11-26
发明人： MATA NATHAN L , REID SILVIA N , PHAN KIM B , HAN YUN , BUI TAM V , HADDACH MUSTAPHA
IPC分类号： C07D401/12 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61P27/02 , A61P27/06 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14
CPC分类号： C07D211/94 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.018 秒)
