公开(公告)号：EP2528505B1

公开(公告)日：2019-12-11

申请号：EP11700119.8

申请日：2011-01-04

申请人： RSP Systems A/S

发明人： HENNEBERG, Morten ,  BANKE, Stefan, Ovesen ,  WEBER, Anders

IPC分类号： A61B5/145 ,  A61B5/00 ,  G01N21/65 ,  A61B5/103 ,  A61B5/1495

公开(公告)号：EP3551974A1

公开(公告)日：2019-10-16

申请号：EP17794698.5

申请日：2017-10-24

申请人： RSP Systems A/S

发明人： BANKE, Stefan, Ovesen

IPC分类号： G01J3/02 ,  G01J3/12 ,  G01J3/18 ,  G01J3/28 ,  G01J3/36 ,  G01J3/44

公开(公告)号：EP4436462A1

公开(公告)日：2024-10-02

申请号：EP22802927.8

申请日：2022-10-12

申请人： RSP Systems A/S

发明人： LUNDSGAARD-NIELSEN, Signe Maria ,  PORS, Anders ,  WEBER, Anders

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1495 ,  G01N21/65

CPC分类号： A61B5/0075 ,  A61B5/1495 ,  A61B5/14532 ,  G01N21/65 ,  G01N21/274

公开(公告)号：EP3616603A1

公开(公告)日：2020-03-04

申请号：EP18191854.1

申请日：2018-08-30

申请人： RSP Systems A/S

发明人： Banke, Stefan Ovesen ,  Lundsgaard-Nielsen, Signe Maria ,  Schjoldager Nielsen, Martin

IPC分类号： A61B5/00 ,  A61B5/11 ,  A61B5/145

摘要： The present invention relates to an apparatus for transdermal in vivo measurement by Raman spectroscopy at a skin region of a body part and to a method of blocking ambient light. The apparatus comprises at least one housing part, a sensor window provided along said at least one housing part, the window having a first side configured to have the skin region applied thereon, and an optical sensor arranged on a second side of the window. The housing part comprises at least one protruded and/or recessed light blocking structure that extends at least partially around said window and is configured to engage with the skin region.

公开(公告)号：EP3193701B1

公开(公告)日：2018-09-26

申请号：EP15762934.6

申请日：2015-08-24

申请人： RSP Systems A/S

发明人： BANKE, Stefan Ovesen

IPC分类号： A61B5/00 ,  G01J3/44 ,  G01N21/65 ,  A61B5/145 ,  A61B5/1455

CPC分类号： A61B5/0075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/7221 ,  G01J1/4257 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/44 ,  G01N21/65

摘要： The use of a transdermal Raman spectrum to measure glucose or other substance concentration can give an inaccurate result if the Raman signals originate at a wrong skin depth. To predict whether a spectrum of Raman signals received transdermally in a confocal detector apparatus and having at least one component expected to have an intensity representing the concentration of glucose or another skin component at a point of origin of the Raman signals below the surface of the skin will accurately represent the concentration, peaks in the spectrum at 883/4 cm−1 and 894 cm−1 are measured to determine whether the Raman signals originate primarily within the stratum corneum so that the spectrum will be less likely to represent the concentration accurately or originate primarily below the stratum corneum so that the spectrum will be more likely to represent the concentration accurately.

公开(公告)号：EP3193701A1

公开(公告)日：2017-07-26

申请号：EP15762934.6

申请日：2015-08-24

申请人： RSP Systems A/S

发明人： BANKE, Stefan Ovesen

IPC分类号： A61B5/00 ,  G01J3/44 ,  G01N21/65 ,  A61B5/145 ,  A61B5/1455

CPC分类号： A61B5/0075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/7221 ,  G01J1/4257 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/44 ,  G01N21/65

摘要： The use of a transdermal Raman spectrum to measure glucose or other substance concentration can give an inaccurate result if the Raman signals originate at a wrong skin depth. To predict whether a spectrum of Raman signals received transdermally in a confocal detector apparatus and having at least one component expected to have an intensity representing the concentration of glucose or another skin component at a point of origin of the Raman signals below the surface of the skin will accurately represent the concentration, peaks in the spectrum at 883/4 cm−1 and 894 cm−1 are measured to determine whether the Raman signals originate primarily within the stratum corneum so that the spectrum will be less likely to represent the concentration accurately or originate primarily below the stratum corneum so that the spectrum will be more likely to represent the concentration accurately.

摘要翻译： 如果拉曼信号源于错误的趋肤深度，使用透皮拉曼光谱测量葡萄糖或其他物质浓度可能会导致不准确的结果。 为了预测在共焦探测器装置中经皮肤接收的拉曼光谱信号是否具有至少一个预期具有代表葡萄糖浓度的强度或在皮肤表面以下的所述拉曼信号的起源点处的另一皮肤成分 将精确地表示所述浓度，测量883 / 4cm-1和894cm-1处的光谱峰值，以确定拉曼信号是否主要起源于角质层内，使得光谱将不太可能精确地表示所述浓度或主要起源于 低于角质层，使得光谱更可能精确地表示所述浓度。

公开(公告)号：EP2416697A1

公开(公告)日：2012-02-15

申请号：EP09776157.1

申请日：2009-03-12

申请人： RSP Systems A/S

发明人： HENNEBERG, Morten

IPC分类号： A61B5/00

CPC分类号： G02B21/0096 ,  A61B5/0059 ,  A61B5/0068 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61B2562/0242 ,  G01N21/31 ,  G01N21/64 ,  G02B21/082

摘要： An optical probe for measuring light signals includes a first optical fiber guiding incoming light, a lens focusing incoming light towards a sample and collecting altered light from the sample, a second optical fiber guiding altered light, a light logging device measuring intensity fluctuations in the incoming light, wherein the light logging device is positioned after the first optical fiber, whereby the light logging device receives a part of the incoming light from the first fiber. The optical probe is normally applied for measuring light signals in vivo, and finds its primary applications within the field of optical spectroscopic measurements, where the light signals measured by the probe are applied in combination with an apparatus wherein light signals are analyzed against its spectral components for instance in Raman, fluorescence, phosphorescence absorption, diffusion and transmission studies.

摘要翻译： 用于测量光信号的光学探针包括：引导入射光的第一光纤，将入射光聚焦到样品并收集来自样品的改变的光的透镜，引导改变的光的第二光纤，测量入射中的强度波动的光测井装置 光，其中所述光测量装置位于所述第一光纤之后，由此所述光测量装置接收来自所述第一光纤的一部分入射光。 光学探针通常用于体内测量光信号，并且在光谱测量领域中发现其主要应用，其中由所述探针测量的光信号与其中光信号针对其光谱分量分析的装置结合使用 例如在拉曼，荧光，磷光吸收，扩散和透射研究中。 本发明的实施方案特别涉及并在拉曼光谱学领域中应用。