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公开(公告)号:EP4328304A3
公开(公告)日:2024-08-28
申请号:EP23206260.4
申请日:2011-02-07
发明人: DOYON, Yannick , MILLER, Jeffrey C.
IPC分类号: C12N9/22 , C07K14/195
CPC分类号: C12N9/22 , C07K2319/5020130101 , C07K2319/8020130101 , C07K2319/8120130101 , C12Y301/21004
摘要: Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.
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公开(公告)号:EP3594333B1
公开(公告)日:2023-11-01
申请号:EP19187729.9
申请日:2011-02-07
发明人: DOYON, Yannick , MILLER, Jeffrey C.
IPC分类号: C12N9/22
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公开(公告)号:EP3504327B1
公开(公告)日:2021-10-06
申请号:EP17844412.1
申请日:2017-08-24
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公开(公告)号:EP3080274B1
公开(公告)日:2020-06-03
申请号:EP14869719.6
申请日:2014-12-09
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公开(公告)号:EP3311822B1
公开(公告)日:2020-05-13
申请号:EP17205646.7
申请日:2011-11-17
发明人: GREGORY, Philip D. , HOLMES, Michael C. , MENDEL, Matthew C. , MENG, Xiangdong , PASCHON, David , REIK, Andreas , URNOV, Fyodor
IPC分类号: A61K31/7088 , C07K14/435 , C07H21/00 , C12N5/0783 , A61P35/00 , A61P31/12 , C12N9/22 , A61K38/17 , A61K35/17
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公开(公告)号:EP2566972B1
公开(公告)日:2020-01-15
申请号:EP11777690.6
申请日:2011-05-02
发明人: PASCHON, David , REBAR, Edward J.
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公开(公告)号:EP2622090B1
公开(公告)日:2019-06-19
申请号:EP11831256.0
申请日:2011-09-26
发明人: HOLMES, Michael C. , WANG, Jianbin
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