-
公开(公告)号：EP3311822B1
公开(公告)日：2020-05-13
申请号：EP17205646.7
申请日：2011-11-17
发明人： GREGORY, Philip D. , HOLMES, Michael C. , MENDEL, Matthew C. , MENG, Xiangdong , PASCHON, David , REIK, Andreas , URNOV, Fyodor
IPC分类号： A61K31/7088 , C07K14/435 , C07H21/00 , C12N5/0783 , A61P35/00 , A61P31/12 , C12N9/22 , A61K38/17 , A61K35/17
-
公开(公告)号：EP2844754B1
公开(公告)日：2018-10-24
申请号：EP13784528.5
申请日：2013-05-02
发明人： SHUKLA, Vipula , GUPTA, Manju , URNOV, Fyodor , GUSCHIN, Dmitry , JAN DE BOTH, Michiel , BUNDOCK, Paul , SASTRY-DENT, Lakshmi
CPC分类号： C12N9/0006 , A01C14/00 , C12N15/8213 , C12N15/8241 , C12N15/8243 , C12N15/8261 , C12N15/8269 , C12Y101/01037 , C12Y301/00 , Y02A40/146
摘要： Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.
-
公开(公告)号：EP1651660B1
公开(公告)日：2018-01-24
申请号：EP04780272.3
申请日：2004-08-06
CPC分类号： C12N15/10 , C07K14/4702 , C07K2319/00 , C07K2319/81 , C12N9/22 , C12N15/902
摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to M the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.
-
公开(公告)号：EP2640399B1
公开(公告)日：2017-12-20
申请号：EP11840913.5
申请日：2011-11-17
发明人： GREGORY, Philip D. , HOLMES, Michael C. , MENDEL, Matthew C. , MENG, Xiangdong , PASCHON, David , REIK, Andreas , URNOV, Fyodor
IPC分类号： A61K31/7088 , C07K14/435 , C07H21/00 , C12N5/0783 , A61P35/00 , A61P31/12 , C12N9/22 , A61K38/17
CPC分类号： A61K38/1709 , A61K35/17 , A61P31/12 , A61P35/00 , C07K2319/71 , C12N9/22
摘要： Disclosed herein are methods and compositions for modulating expression of a PD1 gene.
-
公开(公告)号：EP3730615A2
公开(公告)日：2020-10-28
申请号：EP20173697.2
申请日：2014-05-15
发明人： CONWAY, Anthony , COST, Gregory J. , DEKELVER, Russell , REBAR, Edward J. , REIK, Andreas , URNOV, Fyodor , WANG, Jianbin , ZHANG, H. Steve
IPC分类号： C12N15/11 , C12N9/22 , C12N15/90 , C12N15/63 , C07K14/805
摘要： Methods and compositions for genetic alteration of cells are provided
-
公开(公告)号：EP3034084B1
公开(公告)日：2018-08-01
申请号：EP16150673.8
申请日：2011-11-17
发明人： GREGORY, Philip D. , HOLMES, Michael C. , MENDEL, Matthew C. , MENG, Xiangdong , PASCHON, David , REIK, Andreas , URNOV, Fyodor
IPC分类号： A61K31/7088 , C07K14/435 , C07H21/00 , C12N5/0783 , A61P35/00 , A61P31/12 , C12N9/22 , A61K38/17 , A61K35/17
CPC分类号： A61K38/1709 , A61K35/17 , A61P31/12 , A61P35/00 , C07K2319/71 , C12N9/22 , Y02A50/463
摘要： Disclosed herein are methods and compositions for modulating expression of a PD1 gene.
-
公开(公告)号：EP3156494B1
公开(公告)日：2018-04-25
申请号：EP16200237.2
申请日：2009-12-03
发明人： CUI, Xiaoxia , GEURTS, Aron M. , URNOV, Fyodor
IPC分类号： C12N15/85
CPC分类号： C12N15/907 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2217/054 , A01K2217/15 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K2319/00 , C07K2319/81 , C12N9/22 , C12N15/1024 , C12N15/8509 , C12N2015/8527 , C12N2800/80
摘要： Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
-
公开(公告)号：EP2419511B1
公开(公告)日：2018-01-17
申请号：EP10761996.7
申请日：2010-04-08
发明人： GREGORY, Philip, D. , HOCKEMEYER, Dirk , HOLMES, Michael C. , JAENISH, Rudolf , SOLDNER, Frank , URNOV, Fyodor , YAO, Shuyuan
CPC分类号： C12N15/86 , C12N9/22 , C12N2710/10343 , C12N2740/15043 , C12N2800/30 , C12N2830/008
摘要： Disclosed herein are methods and compositions for targeted integration of sequences of interest such as lineage-specific or cell fate reporter constructs or protein encoding sequences into stem cells.
-
公开(公告)号：EP2771457B1
公开(公告)日：2017-11-22
申请号：EP12844270.4
申请日：2012-10-25
发明人： COST, Gregory J. , HOLMES, Michael C. , KASAHARA, Noriyuki , LAGANIERE, Josee , MILLER, Jeffrey C. , PASCHON, David , REBAR, Edward J. , URNOV, Fyodor , ZHANG, Lei
CPC分类号： C12N15/85 , C07K2319/81 , C12N9/1077 , C12N9/22 , C12N9/96 , C12N15/907 , C12Y204/02008 , C12Y301/21004
摘要： Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals.
-
公开(公告)号：EP3492593A1
公开(公告)日：2019-06-05
申请号：EP18214711.6
申请日：2014-11-13
发明人： ORKIN, Stuart H. , REIK, Andreas , URNOV, Fyodor
IPC分类号： C12N15/09 , A61K38/46 , A61P7/00 , A61K35/12 , A61K35/28 , C07K14/47 , C12N9/22 , C12N15/113
摘要： The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.031 秒)
