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公开(公告)号：EP2305293A3
公开(公告)日：2013-11-06
申请号：EP10012889.1
申请日：1998-10-20
CPC分类号： A61K39/08 , A61K39/00 , A61K2039/505 , A61K2039/54 , C07K14/33 , C07K16/1282
摘要： The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin. C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids. C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
摘要翻译： 本发明提供了预防和治疗艰难梭菌感染的主动和被动免疫方法，其涉及经皮施用艰难梭菌毒素中和性多克隆免疫球蛋白。 艰难梭菌类毒素或其组合。 本发明还提供了艰难梭菌类毒素。 艰难梭菌毒素中和性多克隆免疫球蛋白，以及鉴定产生艰难梭菌毒素中和性多克隆免疫球蛋白的受试者的方法。
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公开(公告)号：EP2329029A4
公开(公告)日：2012-08-01
申请号：EP09816870
申请日：2009-09-24
发明人： FANG AIQI , WHITE ANDREW JAMES , TUMMALA SESHU , WILSON LEE
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公开(公告)号：EP2257308A4
公开(公告)日：2012-06-27
申请号：EP09726224
申请日：2009-03-27
IPC分类号： A61K39/145 , A61K39/125 , A61K48/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/521 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/55544 , A61K2039/55583 , C07K2319/00 , C12N2730/10134 , C12N2760/16134 , C12N2770/32743
摘要： The invention provides rhinovirus vectors, which can be used in the delivery of immunogens, such as influenza virus immunogens, and corresponding compositions and methods.
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公开(公告)号：EP1572234B1
公开(公告)日：2012-02-22
申请号：EP03812906.0
申请日：2003-12-10
IPC分类号： A61K39/29 , A61K39/00 , A61K39/385 , A61K39/295 , C07K17/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K2039/5256 , A61K2039/5258 , A61K2039/55505 , A61K2039/6075 , C07K2319/00 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2760/16122 , C12N2760/16134 , Y02A50/484
摘要： A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (core) protein (HBc) that is engineered for both enhanced stability of self-assembled particles and the substantial absence of nucleic acid binding by those particles is disclosed. The chimeric protein molecule can include one or more immunogenic epitopes peptide-bonded to one or more of the N-terminus, the immunogenic loop or the C-terminus of HBc. The enhanced stability of self-assembled particles is obtained by the presence of at least one heterologous cysteine residue near one or both of the amino-terminus and carboxy-terminus of the chimer molecule and the absence of the cysteine residues present in the native sequence at HBc positions 48 and 107.
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公开(公告)号：EP2305303A2
公开(公告)日：2011-04-06
申请号：EP10013117.6
申请日：1998-10-20
CPC分类号： A61K39/08 , A61K39/00 , A61K2039/505 , A61K2039/54 , C07K14/33 , C07K16/1282
摘要： The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin. C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids. C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
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6.发明公开CONSTRUCTION OF RECOMBINANT VIRUS VACCINES BY DIRECT TRANSPOSON-MEDIATED INSERTION OF FOREIGN IMMUNOLOGIC DETERMINANTS INTO VECTOR VIRUS PROTEINS 有权重组病毒疫苗BY直接转座子的构建双向使用的外国免疫学决定因素病毒载体的病毒蛋白
公开(公告)号：EP2043681A2
公开(公告)日：2009-04-08
申请号：EP07852387.5
申请日：2007-07-16
IPC分类号： A61K39/12
CPC分类号： C12N7/00 , A61K2039/5256 , C12N15/86 , C12N2770/24143 , C12N2770/24151 , C12N2800/50 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396
摘要： The invention provides viral vectors, such as chimeric flavivirus vectors, including foreign peptides inserted into the target proteins of the vectors, methods of making and using these vectors, and compositions including the vectors.
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公开(公告)号：EP2305303A3
公开(公告)日：2013-11-13
申请号：EP10013117.6
申请日：1998-10-20
CPC分类号： A61K39/08 , A61K39/00 , A61K2039/505 , A61K2039/54 , C07K14/33 , C07K16/1282
摘要： The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin. C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids. C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
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公开(公告)号：EP1401859B1
公开(公告)日：2013-08-07
申请号：EP02756112.5
申请日：2002-05-31
IPC分类号： A61K39/295 , C12N7/01 , C12N15/86 , A61K39/00
CPC分类号： C12N15/86 , C12N2770/24143
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公开(公告)号：EP2394658A2
公开(公告)日：2011-12-14
申请号：EP11002684.6
申请日：2004-12-15
CPC分类号： A61K39/08 , A61K39/00 , A61K39/39 , A61K2039/505 , A61K2039/521 , A61K2039/54 , A61K2039/55505 , A61K2039/55511 , C07K14/33 , C07K16/1282 , C07K2317/76 , C12N9/1051 , G01N33/56911 , G01N2333/33 , G01N2469/20
摘要： The invention provides active and passive immunization methods for preventing and treating Clostridium Difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
摘要翻译： 本发明提供了用于预防和治疗艰难梭菌感染的主动和被动免疫方法，其涉及经皮给予艰难梭菌毒素中和多克隆免疫球蛋白，艰难梭菌类毒素或其组合。 本发明还提供了艰难梭菌类毒素，艰难梭菌毒素中和多克隆免疫球蛋白，以及识别产生艰难梭菌毒素中和多克隆免疫球蛋白的受试者的方法。
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公开(公告)号：EP2295023A1
公开(公告)日：2011-03-16
申请号：EP10013094.7
申请日：2003-01-15
CPC分类号： A61K39/12 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The invention provides flavivirus vaccines and methods of making and using these vaccines.
摘要翻译： 本发明提供了黄病毒疫苗和制备和使用这些疫苗的方法。
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